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121	Socio-cultural factors in womens leadership and careers	ABS-43
Women Leaders in the Perspective of South Sulawesi People: A Exploratory Study Ichlas Nanang Afandi Department of Psychology Medical Faculty Hasanuddin University Abstract Since then until now, the issue of whether or not women should be leaders is still a matter of controversy. There are groups that refuse, some are not. Women in the leadership vortex are a never-ending problem. As an entity, South Sulawesi is an administrative area which of course has its own perspective on women leaders. The province, which is mostly inhabited by the Bugis-Makassar tribe, of course has its own values related to how they perceive female leaders. This research is an exploratory study which tries to explore how the people of South Sulawesi view womens leadership. A total of 320 respondents from South Sulawesi participated in filling out an open questionnaire. The data obtained were then analyzed using coding techniques using the principle of thematic inductive analysis. The results showed that the people of South Sulawesi varied in their view of women leaders. In the feasible or not category, 56% of respondents said they were feasible and 44% said they were not. In the category of reasons they stated that they were worthy, the most prominent response was that women also deserve to be leaders as long as they have the ability. While in the category of reasons they stated that they were not worthy, the most prominent response was because religion prohibits women from becoming leaders. Keywords: Women leaders, perspective of South Sulawesi people, exploratory study Share Link | Plain Format | Corresponding Author (Ichlas Nanang Afandi)

122	Socio-cultural factors in womens leadership and careers	ABS-139
The Influence of Transformational Leadership and Organizational Culture on Organizational Citizenship Behavior with job satisfaction as an intervening variable for female staff at PT. Primissima in Sleman, Yogyakarta Rabiyatul Adawiyah Algadri , Mahlia Muis, Abdul Razak Munir Magister Sience of Management, Faculty of Economics and Business, Hasanuddin University, Makassar, Indonesia. Abstract This study is aimed to examine the effect of transformational leadership and organizational culture on organizational citizenship behavior (OCB) with job satisfaction as an intervening variable for female staff at PT. Primissima in Sleman, Yogyakarta. This research is a quantitative descriptive study with a population of 50 female staff. The sampling technique is saturated because the population is relatively small. Methods of data collection were used through the distribution of questionnaires which is tested the validity and reliability of all items evaluated afterward. Data analysis was performed using Statistical Product and Service Solution (SPSS) and analysed using path analysis. To evaluate the indirect effect between variables, the study applied the Sobel Test. The results show that there is a significant influence of the Transformational Leadership variable on Job Satisfaction, there is a significant influence of the Organizational Culture variable on Job Satisfaction, there is a significant influence of the Transformational Leadership variable on Organizational Citizenship Behavior, there is no significant influence from the variable Organizational Culture on Organizational Citizenship Behavior, there is no significant influence of the Job Satisfaction variable on Organizational Citizenship Behavior, there is a significant indirect effect of transformational leadership variables on organizational citizenship behavior through job satisfaction, there is no significance effect direct of organizational culture variables on organizational citizenship behavior through job satisfaction. Keywords: Transformational Leadership, Organizational Culture, Organizational Citizenship Behavior (OCB), job satisfaction Share Link | Plain Format | Corresponding Author (Rabiyatul Adawiyah Algadri)

123	Women and cancer	ABS-3
THE COMPARISON OF ADNEX RISK MODEL WITH RMI (RISK OF MALIGNANCY INDEX) 3 IN DISCRIMINATING PREOPERATIVE BENIGN AND MALIGNANT OVARIAN MASS Yohanes Iddo Adventa, Sharvianty Arifuddin, Syahruni Syahrir, St. Nur Asni, Syahrul Rauf, Rudy B. Leonardy Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Abstract Background: Ovarian carcinoma remains one of mayor problems in Oncology Gynecology. Many methods have been proposed to evaluate ovarian carcinoma risks. This study analyzes the comparison between ADNEX (Assesment of Different NEoplasias in the adneXa) Risk Model with RMI (Risk of Malignancy Index) 3 discriminating preoperative benign and malignant ovarian mass. Methods: A comparative analytic cross-sectional study on 63 participants. Data and blood samples were taken from women with ovarian tumor diagnosis in associated hospitals. ACC, SENS, SPEC, PPV dan NPV were evaluated in both predictors and statistical analysis was performed using Chi Square to evaluate menopausal and parity status correlation. Results: From 63 total samples, consist 40 malignant and 23 benign tumors from pathology anatomy diagnosis. Both ADNEX Risk Model and RMI 3 predict 35 malignant and 28 benign tumors. The vallue of ACC, SENS, SPEC, PPV and NPV from RMI 3 analysis (79.37, 77.5, 82.6, 88.6, and 67.9%) higher than ADNEX Risk Model (73.02, 72.5, 73.9 82.9 and 60.7%). RMI 3 correlates significantly with all menopause and parity status (p = 0.0001 for premenopause, p = 0.0054 for postmenopause, p = 0.000 for nulipara and p = 0.0046 for parity >1). ADNEX Risk Model statistically significant in all parity status and premenopause group (p = 0.0004 for premenopause, p = 0.0633 for postmenopause, p = 0.001 for nulipara and p = 0.0275 for parity >1). Conclusion: Both predictor tools have good performance in discriminating preoperative benign and malignant ovarian mass. RMI 3 is better in discriminating preoperative benign and malignant ovarian mass than ADNEX Risk Model. Keywords: ADNEX Risk Model, RMI 3, ovarian tumor, maligancy Share Link | Plain Format | Corresponding Author (Yohanes Iddo)

124	Women and cancer	ABS-6
SPONTANEOUS TERM PREGNANCY IN ANOGENITAL MALFORMATION POST COLOSTOMY (BLIND END VAGINAL SEXUAL INTERCOURSE) Yohanes Iddo Adventa1, Trika Irianta2, Eddy Tiro3, David Lotisna4 1) Resident at Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 2) Staff at Urogynecology and Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 3) Staff at Social Obstetric and Gynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanudin University, Makassar, Indonesia 4) Staff at Urogynecology and Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Abstract Introduction: The prevalence of female genital tract congenital anomaly is 4% until 7%, including blind end vagina. Hymen and vaginal anomaly could restrict menstruation, sexual activity, fertility, and delivery. Vaginal anomaly is related to other genital tract anomalies and extragenital abnormalities. Preoperative spontaneous pregnancy in blind end vagina is a rare case. Case: Young married women, 22 years old with Gravida 1 Para 0 Abortus 0 had term pregnancy by blind and vaginal sexual intercourse. During the second day of her life, she had a repair of atresia ani and structure occurred. The patient had defecation difficulty during her life and had a limited diet. After her marriage, vaginal agenesis was diagnosed and imaging examination showed a vesicovaginal fistula with ectopic vagina opening into the lumen of rectum. 6 months before pregnancy, a colostomy procedure was performed to improve quailty of life. Caesarean section delivery at term was performed at emergency theatre with no complication due to uterine contractions. A healthy female baby was delivered with normal anatomy. Informed choice and education had been delivered to the patient for vaginal reconstruction and the patient chose to delay the procedure because of previous normal spontaneous pregnancy. Result: Pelvic examination is mandatory for vaginal anomaly diagnosis. Imaging modalities can explore other genital or extragenital abnormalities related to blind end vagina. Reconstruction management can be offered to improve the quality of life. Conclusion: Management such as anomalies depends on patient preferences since spontaneous pregnancy occurred by unusual sexual intercourse. Caesarean delivery is the only preferable management in pregnancy in blind end vagina case Keywords: blind end vagina, vaginal anomaly, spontaneous pregnancy, fistula Share Link | Plain Format | Corresponding Author (Yohanes Iddo)

125	Women and cancer	ABS-9
The Profile of MICA expression in Atypical Duct Hyperplasia and Ductal Carcinoma Insitu of Breast Tumor Rina Masadah1, Nurkhairaty1, Dzul ikram1,2, Berti Nelwan1, Tarsisia Truly Djimahit1 1 Department of Pathology Anatomy, Hasanuddin University, Makassar, Indonesia; 2 Department of Histology, Muslim University of Indonesia, Makassar, Indonesia Abstract Introduction: Breast cancer is one of the most common cancers in women throughout the world. Its etiology and pathogenesis are complex, leads the morbidity and mortality of this disease still high until now. It has been known that breast cancer occurs from the transformation of precancerous breast tumor, so that it is important to understand the gene expression that plays a role in precancerous breast tumor such as Atypical Duct Hyperplasia (ADH) and Ductal Carcinoma Insitu (DCIS) in order to develop early detection and prompt treatment of this fatal disease. Major histocompatibility Complex class I polypeptide-related sequence A (MICA), is a ligand of Natural Killer Group 2D (NKG2D) receptor gene that expressed by NK of T inflamation cells. MICA could be used as a marker of inflammation process in tumor cells immunosurvailance, as known that inflammation process is important pathway for precancerous cells to differentiate. In this study we analyzed the expression of MICA in ADH and DCIS tissues to elucidate its role in precancerous breast tumor. Methods: Immunohistochemistry method using antibody of MICA had been applied to 29 of ADH and 30 of DCIS tissue samples. MICA expression was analyzed statistically to histological type of breast tumor. Results: We found that the mean score of MICA in ADH and DCIS was 2.31 0.71 and 2.32 0.89 repectively, with no significant diferentiation statistically (p=1.00). The expression of MICA in ADH and DCIS was medium intense in all samples. Conclusions: MICA showed positive expression in ADH and DCIS, this finding showed that MICA is play a role in breast precancer tumor. Keywords: MICA, Atypical Duct Hiperplasia, Ductal Carcinoma Insitu, breast precancer tumor Share Link | Plain Format | Corresponding Author (Rina Masadah)

126	Women and cancer	ABS-10
Clinicopathological factors of stage IB-IIB cervical cancer following neoadjuvant chemotherapy relevant to intraoperative bleeding and transfusion, ICU admission and length of stay Nurkamilawati Arista (a*), Nugraha Utama Pelupessy (b), Rudy Butje Leonardy (a), Firdaus Hamid (c), Sharvianty Arifuddin (b), Susiawaty (a) a)Department of Obstetrics and Gynecology, Faculty of Medicine Hassanuddin University, Makassar 90245, Indonesia *nurkamilawati.arista[at]gmail.com b)Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hassanuddin University, Makassar, Indonesia c)Department of Microbiology, Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia Abstract Objective : To compare the efficacy of NACT followed by surgery with surgery alone in cervical cancer stage IB-IIB. Method : Forty-three cervical cancer stage IB-IIB were included in this study. Platinum-based chemotherapy were performed three or six cycles consisted of intravenous paclitaxel (175 mg/m2) and cisplatin (50 mg/m2) or carboplatin (300-400 mg/m2 ) with 3 weeks interval followed by surgery in first group (24 respondents) and primary surgery in second group (19 respondents). Result : Analytical test results showed levels of leukocytes (p = 0.002) and platelets (p = 0.001) were lower in the NACT group. Intraoperative bleeding (627.08 ml vs 605.26 ml) and intraopoerative transfusion (8 vs 6 ) were higher in NACT Group. Positive LVSI was obtained 25% vs 57.89% , tumor sizes were significantly smaller in NACT group (p <0.001). Conclusion : NACT administration increase operability and improve pathologic prognostic factors, ,but increases of hematological side effect and intraoperative complication Keywords: Cervical cancer stage IB-IIB, NACT, Clinicophatological factors Share Link | Plain Format | Corresponding Author (Nurkamilawati Arista)

127	Women and cancer	ABS-40
The Relationship of Family Support with Decision Making Duration in Cancer Patient to Perform Mastectomy Feny Tunjungsari (1*), Ayu Ratuati Setiawan (2), Mochamad Aleq Sander (3) (1) Departement of Industry & Family Medicine , University of Muhammadiyah Malang, Malang 65145, Indonesia *feny.tunjungsari[at]gmail.com (2) Faculty of Medicine, University of Muhammadiyah Malang, Malang 65145, Indonesia (3) Departement of Surgery, University of Muhammadiyah Malang, Malang 65145, Indonesia Abstract Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision making determine the survival rate of prognosis patients. The aim of this study was to determine the relationshiop of family support with decision making duration in cancer patient to perform mastectomy. The method was an analytic observation method with cross-sectional design. The samples taken by purposive sampling method with 50 samples of breast cancer patients from X Hospital Surabaya. Data collected include age, last level of education, marital status, proffesion, stage of cancer during mastectomy, family support score, and decision making duration to perform mastectomy. The data analyzed with Kruskal-Wallis bivariate test. The bivariate test showed the relationship of family support (p=0.002) with decision making duration in breast cancer patient to perform mastectomy. In conclusion, there is relationship of family support with decision making duration in breast cancer patient to perform mastectomy. Keywords: breast cancer, family support, decision making duration, mastectomy Share Link | Plain Format | Corresponding Author (Feny Tunjungsari)

128	Women and cancer	ABS-42
The Relationship of Self-Acceptance with Decision Making Duration in Cancer Patient to Perform Mastectomy Ayu Ratuati Setiawan (1), Feny Tunjungsari (2*), Mochamad Aleq Sander (3) (1) Faculty of Medicine, University of Muhammadiyah Malang, Malang 65145, Indonesia (2) Departement of Industry & Family Medicine, University of Muhammadiyah Malang, Malang 65145, Indonesia *feny.tunjungsari[at]gmail.com (3) Departement of Surgery, University of Muhammadiyah Malang, Malang 65145, Indonesia Abstract Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision making determine the survival rate of prognosis patients. The aim of this study was to determine the relationship of self-acceptance with decision making duration in cancer patient to perform mastectomy. An analytic observation method with cross-sectional design. The samples taken by purposive sampling method with 50 samples of breast cancer patients from X hospital Surabaya. Data collected include age, last level of education, marital status, proffesion, stage of cancer during mastectomy, self-acceptance score, and decision making duration to perform mastectomy. The data analyzed with Kruskal-Wallis bivariate test. The bivariate test showed the relatiosnhip of self-acceptance (p=0.027) with decision making duration in breast cancer patient to perform mastectomy. In Conclusion, there is relationship of self-acceptance with decision making duration in breast cancer patient to perform mastectomy. Keywords: breast cancer, self-acceptance, decision making duration, mastectomy Share Link | Plain Format | Corresponding Author (Feny Tunjungsari)

129	Women and cancer	ABS-57
Correlation between pre-operative peripheral blood monocyte lymphocyte ratio and clinical staging, histological type, grade of differentiation in epithelial ovarian carcinoma Suwandi, Syahrul Rauf, Irnawaty Bahar, St Nur Asni, Nugraha UP, Ajardiana Obstetric and Gynaecology Department Medical Faculty of Hasanuddin University Abstract This study was aimed to identify correlation between preoperative peripheral blood monocyte lymphocyte ratio and clinical staging, histological type, as well as grade of differentiation in epithelial ovarian carcinoma.This study was a cross sectional study and was conducted at Wahidin Sudirohusodo Hospital, Makassar commence in January to December 2019. There were 100 participant with epithelial ovarian carcinoma in this study.Peripheral blood monocyte lympchocyte ratio had positive correlation with clinical staging of epithelial ovarian cancer.Stage IV ovarian cancer tend to have higher mean monocyte lymphocyte ratio than stage I ovarian cancer.Mean monocyte lymphocyte ratio in mucinous.Endometrioid and clear cell type were respectively.Serous type ovarian cancer was more likely to have higher monocyte lymphocyte ratio compared with other types.This finding was different from well differentiated ovarian cancer that have lower mean monocyte lymphocyte ratio Keywords: Epithelial ovarian carcinoma, monocyte lymphocyte ratio, ovarian carcinoma Share Link | Plain Format | Corresponding Author (Suwandi Suwitri)

130	Women and cancer	ABS-59
Health-Related Quality of Life in Cervical Cancer Survivor Grestin Sandy, Nadhia Renaldi Hasanuddin University Abstract Objective: This study aims to describe health-related Quality of Life in cervical cancer survivor between high and low Health-Related Quality of Life. Methods: This study used Qualitative Approach with Narrative study. Five Cervical Cancer Survivors already participated to this study, as the result of purposive sampling method with WHOQOL-BREF scale (1998) and interview. Results: This study shows that the differences in Health-Related Quality of Life in the cancer survivor can be seen from the time span of becoming survivor. The longer participants become survivor, the more likely it is to have low Health-Related Quality of Life. Conclusion: There are differences between high and low health related quality of life in cervical cancer survivor. Keywords: Health-Related Quality of Life; Cervical Cancer Survivors Share Link | Plain Format | Corresponding Author (Grestin Sandy)

131	Women and cancer	ABS-77
CHARACTERISTICS OF ORAL CAVITY TUMOR PATIENTS AT DR WAHIDIN SUDIROHUSODO HOSPITAL MAKASSAR IN 2017-2019 CANGARA M. HUSNI, HASTUTI EKA HESTI, MISKAD A UPIK, NELWAN BERTI DEPARTMENT OF ANATOMICAL PATHOLOGY, FACULTY OF MEDICINE, HASANUDDIN UNIVERSITY, MAKASSAR, INDONESIA Abstract A tumor is a group of abnormal cells that result from excessive and uncoordinated cell division. By nature, tumors are divided into benign and malignant tumors. Tumors can also occur in the oral cavity, which is one of the 10 most common cancer sites in the world. About three-quarters of cases involve people in developing countries include Indonesia. This study aims to determine the number and characteristics of patients with tumors of the oral cavity at Wahidin Sudirohusodo General Hospital, Makassar, Indonesia in 2017-2019. This study uses a retrospective descriptive method with secondary data from medical record in 2017-2019. In this study, there are totally 72 samples of patient with oral tumors. Most of patients were in the age group 60-69 years, male, no history of smoking and alcohol consumption, no family history of tumors or cancer, location on the tongue, malignant tumors, with squamous cell carcinoma for malignant tumors and Benign Vascular-lymphatic tumors for benign tumors, and many receive surgical therapy. Keywords: oral tumor, benign oral tumor, malignant oral tumor. Share Link | Plain Format | Corresponding Author (MUHAMMAD HUSNI CANGARA)

132	Women and cancer	ABS-90
Beta catenin and L1CAM Expressions as a Prognostic Marker in Type I Endometrial Carcinoma Yolanda Manule1, Rina Masadah1, Berti J Nelwan1, Djumadi Achmad1, Andi Alfian Zainuddin2, Upik Anderiani Miskad1* 1Department of Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 2Department of Public Health and Community Health Science, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Corresponding Author *upik.miskad[at]med.unhas.ac.id Abstract Objective: This study aimed to assess the expression of beta catenin and L1CAM with their relationship as a prognostic marker in type I endometrial carcinoma. Methods: 49 type I endometrial carcinoma were selected by taking a stratified sampling samples from January 2017 to December 2017. We used the immunohistochemical procedure to evaluate the expression of beta catenin and L1CAM related to prognostic parameters i.e., myometrial invasion, lymphovascular invasion, and metastatic event. Results: The statistical results revealed that there was a significant difference between beta catenin and L1CAM expressions viewed from tumor cells with the depth of myometrial invasion (> 50%), occurrence of lymphovascular invasion, and presence of metastases in type I endometrial carcinoma (p <0.05). Conclusion: This results suggest that the tendency of overexpression of beta catenin together with L1CAM can increase the progression of tumor cells in type I endometrial carcinoma, in its ability to invade myometrium, lymphovascular invasion, and metastasis to other tissues. Our findings indicate that both of beta catenin and L1CAM are promising biomarkers for the prognosis of endometrial carcinoma. Keywords: type I endometrial carcinoma; beta catenin; L1CAM; immunohistochemistry Share Link | Plain Format | Corresponding Author (Upik Anderiani Miskad)

133	Women and cancer	ABS-92
The Survival of Patients with Nonepithelial Ovarian Cancer Based on Patients Characteristics and Treatments Gressella Khadijah Mamangkey(1*), Umar Malinta(2), Nugraha Utama Pelupessy(3), Joko Hendarto(4) 1) Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia *gressellamamangkey[at]gmail.com 2) Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 3) Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia 4) Department of Public Health and Preventive Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Abstract Objective: Nonepithelial ovarian cancer is a rare disease with poor prognosis. The aim of present study was to analyze the survivals of patients with nonepithelial ovarian cancer based on patients characteristics and treatments in South Sulawesi, Indonesia. Method: This study used observational cohort design by collecting data from medical records (characteristics and treatments) of the patients whose pathology result was nonepithelial ovarian cancer at Wahidin Sudirohusodo Hospital and Ibnu Sina Hospital from January 2015 until June 2020. Result: Among 498 cases of ovarian cancer, there were 24 cases of nonepithelial ovarian cancer. No variables were significantly associated with the recent status (died or alive) of these patients by multivariate analysis. Survival of these patients was then analyzed with Kaplan Meier method and the only variable associated with better survival was patients underwent chemotherapy. Conclusion: Chemotherapy gives better survival for patients with nonepithelial ovarian cancer. Keywords: Nonepithelial ovarian cancer; survival; patients characteristics Share Link | Plain Format | Corresponding Author (Gressella Khadijah Mamangkey)

134	Women and cancer	ABS-98
CODE BLUE! How Dangerous is COVID-19 to Our Gynecology Patients Mental Health ? Yulfa Rizki Amita, Syahrul Rauf, Fatmawaty Madya Faculty of Medicine Hasanuddin University Abstract Objective: research aims to evaluate depression and anxiety status of gynecology cancer patients during COVID-19 pandemic in Makassar. Methods: Study conducted on 145 patients at Wahidin Sudirohusodo Hospital during June to August 2020 with ZSAS questionnaire. Result: The results of multivariate analysis using logistic regression showed that the PS Score had an effect on depression cases (OR = -0.221; 95% CI -0.342 to (- 0.099)). Pain (OR = 0.678; 95% CI -0,465 to 0,890) and earnings also against depression cases OR = -0.026; 95% CI -0.241 to (- 0.015)) of the three factors that had effect against depression cases, factors which have largest influence are pain (the effect 0.678 times of the cases of depression). Reasons that strongly affect stress level on patients include health service restrictions, negative issues about health workers, doubt to goverment solutions. Conclusion: Depression level significantly increase during COVID 19 pandemic Keywords: Depression , Anxiety , Gynecological Cancer , Covid -19 Share Link | Plain Format | Corresponding Author (Yulfa Rizki Amita)

135	Women and cancer	ABS-107
Impact of Hematologic Malignancy in Women: A systemic Literature Review Rahmawati Minhajat Hematology and Medical Oncology Division. Internal Medicine Department Medical Faculty Hasanuddin University Makassar Abstract Hematologic malignancy or blood cancer are blood cell malignancy originating from bone marrow and lymph nodes, including leukemia, lymphoma, and myeloma. This is a diverse group of diseases which affect both women and men throughout their life. The etiology of hematologic malignancy remain unknown. Ionic radiation, chemical and dust exposure, chemical exposure, viral infection, and genetic predisposition are associated with increased risk. The response, prognosis, and treatment of this diseases also varied. Symptoms of a hematologic malignancy are fatigue, weakness, shortness of breath, fever, bleeding, bruising, joint and bone pain, and recurrent infection. In addition, female patients often experience particular symptoms as heavy menstrual or vaginal bleeding during pregnancy, sometimes lead to infertility and precocious menopause. The aim of this study is to examine the impact of haematologic malignancy in woman. A review of the international literature was conducted from the databases Medline using the combination of keywords of hematologic malignancies, women, female, impact, menstrual, pregnancy, fertility and menopause. Keywords: Hematologic malignancies, Women, menstrual,pregnancy,fertility, menopause Share Link | Plain Format | Corresponding Author (Rahmawati Minhajat)

136	Women and cancer	ABS-114
Expression Of Protein Regenerating Liver-3 (PRL-3) and E-Cadherin: Close Correlation With Metastatic Breast Cancer Upik Anderiani Miskad1, Syakir2, Daniel Sampepajung2, Irawan Yusuf2 1Department of Pathology, Faculty of Medicine, Hasanuddin University, Makassar 2 Faculty of Medicine, Hasanuddin University, Makassar, Indonesia *upik.miskad[at]gmail.com Abstract Objective: Breast cancer is the most common malignant neoplasm worldwide. PRL-3 (protein regenerating liver-3/PTP4A3) was reported participates in the progression and metastatic of various cancer including breast cancer. Recently PRL-3 was suggested to promote epithelial mesenchymal transition (EMT) by downregulating E-cadherin expression. To clarify the molecular mechanisms that involved in breast cancer progression and metastasis, we investigate the expression of PRL-3 and E-Cadherin and correlate the expression with the clinicopathologic parameters. Methods: Expressions of PRL-3 and E-Cadherin in 114 primary breast cancer specimens and 73 limphonode metastasis were detected by immunohistochemistry. Results: Among primary breast cancers examined, there were 11 (9.6%) low grade, 70 (61.4%) moderate grade and 33 (28.9%) high grade malignancy. There were significant correlation between PRL-3 expression and histological grading of breast cancer (p=0.044) and the presence of lymphonode metastasis (p<0.001). The significant correlation was also found between expression of E-cadherin and the presence of LN metastasis (p=0.001). The expression of PRL-3 in primary site was significantly correlated with metastatic site (p<0.001). The result showed that the more higher PRL-3 expression the more lower the expression of E-cadherin in breast cancer. Conclusions: These results strongly suggest that PRL-3 play a role in the progression and metastasis of breast cancer. PRL-3 may down regulate the expression of E cadherin and induce metastatic ability in breast cancer. Keywords: Key words: PRL-3, E-Cadherin, Breast cancer metastasis, Immunohistochemistry Share Link | Plain Format | Corresponding Author (Upik Anderiani Miskad)

137	Women and cancer	ABS-132
The Role of Clinical Pathology Characteristics, CA 125 and Neutrophil-Lymphocyte Ratio as Prognostic Factors of Epithelial Ovarian Cancer Nugraha Utama Pelupessy (a*), Irma Savitri (a), Sharvianty Arifuddin (a), Syahrul Rauf (a), Joko Hendarto (b) a)Division of Gynecologic Oncology,Departement of Obstetrics and gynecology, Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia b) Department of community and preventive medicine,Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia Abstract Introduction :Epithelial ovarian cancer type 2 has the characteristic of rapid tumor growth and genetically more labile than that of type 1. CA 125 and neutrophil-lymphocyte ratio are factors that play a role in the prognosis of epithelial ovarian cancer. Methods: This study used a retrospective cohort and survival analysis. Patient data were taken from medical records at RSUP Dr. Wahidin Sudirohusodo, Makassar and Ibnu Sina Hospital Makassar for the period 2014-2019. Results: The sample consisted of 231 patients. The significant variables were histology (P <0.001 HR 2.64 IK 1.62-4.30) and stage (P <0.001 HR 4.44 IK 2.42- 8.14) while the levels of CA 125 (P = 0.907 HR 1.05 CI 0.48-2.31) and the neutrophil-lymphocyte ratio (P <0.364 HR 1.25 CI 0.77 to 2.02) were not statistically significant. Conclusion: Type 2 epithelial ovarian cancer and advanced stage are the prognostic factors that most play a role in epithelial ovarian cancer. Keywords: epithelial ovarian cancer, prognostic factors Share Link | Plain Format | Corresponding Author (Nugraha Utama Pelupessy)

138	Women and cancer	ABS-137
Effect of Menopausal Status on IL-2 in Epithelial Ovarian Cancer Patients Hijriah Anwar1, Nugraha Utama Pelupessy2, Suzanna S Pakasi1, Maisuri T Chalid3 , Sharvianty Arifuddin2, Nuraini Abidin1 1Department of Obstetrics and Gynecology, Hassanuddin University, Makassar, Indonesia 2Division of Gynecologic Oncology, Department of Obstetrics and Gynecologi, Hassanuddin University, Makassar, Indonesia Email : riririzal2002[at]gmail.com Abstract Objective : The aim of this study was to determine the association of IL-2 with clinical stage, histopathological type, and degree of differentiation epithelial ovarian cancer Method: This was the analytical observational study with cross sectional approach, conducted at Wahidin Sudirohusodo Hospital and its network hospitals in Makassar. Primary data were collected from March 2019 - March 2020. Total sample was 68 women, 34 early stages, 34 advanced stages. Results: There were no significant differences in IL-2 levels on clinical stage, histopathological type, degree of differentiation and tumor residue in epithelial ovarian cancer (p> 0.05). There was a significant increase in IL-2 levels at age more than 50 years and menopause. Conclusion: IL-2 was not associated with clinical stage, histopathological type, degree of differentiation, and IL-2 was associated with increased age and menopausal status. Keywords: Ovarian Cancer, IL-2, Menopause, age Share Link | Plain Format | Corresponding Author (Hijriah Anwar)

139	Women and cancer	ABS-154
MIX GONADAL DYSGENESIS WITH DYSGERMINOMA: CASE REPORT Nuraeni, Sriwijaya, Nusratuddin Abdullah, Sharvianty obstetric gynecology, Hasanuddin University, Makassar, Indonesia nuraenifk03[at]gmail.com Abstract Introduction: Gonadal dysgenesis is one of the common causes of primary amenorrhea. There are three histological categories of gonadal dysgenesis, including Complete Gonadal dysgenesis, Mix Gonadal Dysgenesis, and partial Gonadal dysgenesis. Dysgerminoma is a malignant tumor due to the proliferation of primitive germ cells in the ovary. Cytogenetic disorders involving all or part of the Y chromosome or MGD, especially 45,X / 46,XY are associated with dysgerminoma. Case Report: A 19-year-old woman with complaints of never had menstruation and an enlarged stomach. Karyotyping examination showed the results of chromosomes 45, X/ 46, XY. Total Hysterectomy and Bilateral Salpingo-oophorectomy was performed. Histopathology results showed a left ovarian dysgerminoma. She was treated using adjuvant chemotherapy. Conclusion: In gonadal dysgenesis, the presence of Y chromosome is high risk for developing gonadal tumors (50%) in genotype 46 XY. Dysgerminoma has the best prognosis of all ovarian Germ cell malignant tumor variants. Keywords: Gonadal dysgenesis,Dysgerminoma Share Link | Plain Format | Corresponding Author (Nuraeni Nuraeni)

140	Women and cancer	ABS-158
BREAST CANCER IN WEST NUSA TENGGARA 2010-2020: INCIDENCE AND HISTOLOGICAL TYPE Fathul Djannah(a*), Novrita Padauleng(b) a)Anatomy Pathology Depart. of Medical Faculty Mataram University, Pemuda Street Mataram, Indonesia *fdjannah354[at]gmail.com b)Histology Depart. of Medical Faculty Mataram University, Pemuda Street Mataram, Indonesia Abstract Background : Primer data about type and histological grading of breat carcinoma have not been establish yet in all regions in West Nusa Tenggara, covering 10 districts and cities . The data needs to support comprehensive research . Aim : to obtain incidence data based on histological type in breast cancer in West Nusa Tenggara diagnosed in 2010 to 2020. Methods : retrospective cohort study used secondary data contained in patients medical records in West Nusa Tenggara. Results : the incidence of the beast canser was 986 cases, with histological type breast canser was dominated by invasive duktal type (78,6%), followed by invasive lobular type (11,3%), papillary carcinoma (3,3%), Conclusion : Continuing and more comprehensive research about breast carcinoma and follow up the brease cancer sufferers in West Nusa Tenggara were needed because the incidence of breast canser continued to increase. Keywords: breast cancer, malignancy in NTB, histological type of breast cancer Share Link | Plain Format | Corresponding Author (Fathul Djannah)

141	Women and cancer	ABS-159
Emergency of Cervical Cancer in West Nusa Tenggara Fathul Djannah(a*), Novrita Padauleng(b) a)Anatomy Pathology Depart. of Medical Faculty Mataram University, Pemuda Street Mataram, Indonesia *fdjannah354[at]gmail.com b)Histology Depart. of Medical Faculty Mataram University, Pemuda Street Mataram, Indonesia Abstract Background : Pap smear and biopsy were examination of cervix to screening and diagnose cervical cancer. Data about cervical examination were needed to described the emergency situation of cervical cancer Aim: To define prevalensi of cervical cancer with histopathology and pap smear method in West Nusa Tenggara since 2010 untill 2020 Methods : a observational descriptive study using data patients with cervical examination. Result : There were 3.430 cases of cervical examination in West Nusa Tenggara 2010-2020 consist of 2273 cases of pap smear and 1157 cases of cervical biopsy. The most result of the cercival examinationa were inflamasi in 2156 patients then pre cancer and cancer in 1274 patients while 41-50 group of age were the most patients in this examination and from Central Lombok is the highest burden location. Conclusion : Community knowledge by counseling and awarenees development was needed to decrease incidence of cervical cancer in West Nusa Tenggara. Keywords: ca cervix, cervical cancer, pap smear, malignant in West Nusa Tenggara Share Link | Plain Format | Corresponding Author (Fathul Djannah)

142	Women and cancer	ABS-167
Performance Status Score, Body Mass Index and Pre-Operative Laboratory Findings as Predictor of Length of Hospital Stay in Patient with Post Gynecological Surgery Edward Chandra Koesuma (a*), Samrichard Rambulangi (a), Nugraha Utama Pelupessy (a) (a) Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University Perintis kemerdekaan street, KM 10, Makassar, South Sulawesi, Indonesia*edward.chandra.koesuma[at]gmail.com Abstract Keywords: Karnofsky performance scale, albumin, hemoglobin, platelets, gynecological surgery, length of stay Share Link | Plain Format | Corresponding Author (Edward Chandra Koesuma)

143	Women and cancer	ABS-173
Development of Nurses Caring Behavior Scale for Cancer Patients Undergoing Chemotherapy Using Qualitative Method Yulta Kadang (a), Kusrini Semarwati Kadar (b*) (a) Students of Postgraduate Nursing Program, Faculty of Nursing Universitas Hasanuddin (b) Faculty of Nursing Universitas Hasanuddin *kusrinikadar[at]unhas.ac.id Abstract Background: Receiving chemotherapy treatment is very difficult for cancer patients because the physical and psychological effects are very complex. As care providers, nurses should have ability to improve the quality of care in cancer patients undergoing chemotherapy. Quality care of nursing can be manifested through nursing care based on nurses caring behavior. Swansons theory is expected to contribute to further research in the development of new scales and the validity of the instruments which are already based on the 5 structures of Middle Range Swanson Theory of Caring 1991. Purpose: This study aimed to form a new conceptual framework in domain form and produce statement items through a qualitative approach. Methods: The research utilized a phenomenological approach; in-depth interviews were conducted with five open-ended questions given to 12 participants. Interviews were digitally recorded and transcribed; then, the data were analyzed using content analysis. Findings: Overall, the resulting questionnaire contained 5 main domains with a total of 33 statement items. The first domain is respecting culture with 5 item statements. The second domain is providing information with 6 statement items. The third domain is responsiveness with 7 statement items. The fourth domain is competences with 9 statement items. The fifth domain is providing overall motivation with 6 statement items. Conclusion: Qualitative methods successfully produced a perceptive questionnaire of cancer patients undergoing chemotherapy, evaluating the nurses caring behaviour with five main domains and 33 statement items with positive and negative statement items. Keywords: qualitative methods, cancer patient, chemotherapy, caring, tools development Share Link | Plain Format | Corresponding Author (Kusrini Semarwati Kadar)

144	Women and mental health	ABS-17
Relationship of Estradiol Hormone Levels with Sexual Function in Premenopausal and Postmenopausal Women Indrayani Irwan(a*), Nusratuddin Abdullah (a), Elizabet C Jusuf (a), St. Nur Asni (a), Eddy R Moeljono (a), Abdul Rahman (a) a) Obstetry and Gynecology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia. *indra.irwan[at]yahoo.com Abstract This study aims to assess the relationship of estradiol hormone levels with sexual function in premenopausal women and postmenopausal women. This cross-sectional study was conducted at the teaching hospital in the obstetrics and gynecology department of the Faculty of Medicine, Hasanuddin University, Makassar, from February to July 2019. The sample was parturient women aged 40-60 years who had a partner and had intact genital organs. sexual dysfunction was assessed with the Female Sexual Function Index (FSFI) questionnaire. Estradiol levels were analyzed from venous blood samples. Statistical analysis was performed with SPSS software using Chi-Square Test. Research has been conducted on 78 samples consisting of 42 premenopausal women and 36 postmenopausal women. Estradiol levels of premenopausal and postmenopausal women were 125.27 +/- 69.54 and 67.63 +/- 32.29, respectively. The mean FSFI score in the premenopausal women and postmenopausal women was 23.73 +/- 6.90 and 17.45 +/- 7.16, respectively. There were significant differences in estradiol levels and FSFI scores between the premenopausal women and postmenopausal women (p= 0.000). The correlation between estradiol hormone levels and sexual function in premenopausal women is weak (r = 0.011) and not significant (p - 0.947). In postmenopausal women, the correlation between estradiol hormone levels and sexual function is week (r= 0.006) and not significant (p = 0.973). This study concludes that estradiol hormone affects sexual function in premenopausal and postmenopausal women. Keywords: Estradiol; FSFI; Premenopause; Postmenopause; Sexual dysfunction Share Link | Plain Format | Corresponding Author (Indrayani Irwan)

145	Women and mental health	ABS-18
RISK FACTORS OF POSTPARTUM DEPRESSION AT THE WOMEN AND CHILDREN HOSPITAL IN MAKASSAR Andi Sri Ratnaningsih (1*), Elizabet C. Jusuf (2), Eddy Hartono (2) Department of Obstetrics and Gynecology, Division of Social Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Abstract Objective: To assess risk factors of postpartum depression (PPD). Methods: A cross-sectional study was conducted in February-March 2020 at St. Khadijah I Women and Children Hospital in Makassar. PPD assessment through direct interviews using a Postnatal Risk Questionnaire (PNRQ) questionnaire. The characteristics of the study sample are presented in frequencies and percentages. Multivariate analysis was used to assess the risk factors for postpartum depression. Results: A hundred postpartum women were eligible. Most of the women aged 20 until 35 years (86%), low education (74.0%), unemployment (81%), low socioeconomic status (66%), primiparous (54%), ANC &#8805;4 times (62%), and performed vaginal delivery (67%). Based on PNRQs assessment, 38% of these women were at risk of developing PPD. Significant differences found between the two study groups in terms of education, employment, parity and frequency of ANC (all p<0.05). In contrast, there was no significant differences in terms of age, socioeconomic status and mode of delivery between the two study groups (all p>0.05). Multivariate analysis show parity in women after childbirth had 14 fold risk for experience postpartum depression. Conclusion: Parity is the strong risk factor for postpartum depression. Keywords: Postpartum depression, risk factors Share Link | Plain Format | Corresponding Author (andi sri ratnaningsih)

146	Women and mental health	ABS-22
The Tradition of Mambosuri Toba Batak Traditional Ceremony for a Pregnant Woman with Seven Months Gestational Age for Womens Physical and Mental Health immanuel silaban (a), Robert Sibarani(b*) (a)Postgraduate Department in Linguistics, Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia (b)Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id Abstract This study aimed to determine the process and meaning of the mambosuri tradition for the physical and mental health of Toba Batak women who will give birth to their first child. This research conducted with qualitative methods with interactive models and Anthropolinguistic Approach. Mambosuri tradition (Seven Months) in the Toba Batak tradition is carried out as an initiation, a means used to overcome anxiety because in ancient times. In Mambosuri, life was inadequate, causing the death of many women who were pregnant with their first child. The process of mambosuri begins with the welcoming of female family members by male family members. The pregnant women are given their favorite food (sipanganon), a traditional fabric (ulos), rice (boras si pir ni tondi), traditional food (tudu-tudu sipanganon), and inspiring words (hata sigabe-gabe)." The tradition of mambosuri is hope and prayer at the time of mambosuri, thus increasing the physical and mental health of a mother who is seven months pregnant will feel calmer and believe there is nothing to worry about until the birth arrives. Keywords: Mambosuri, Pregnant women, Toba Batak Share Link | Plain Format | Corresponding Author (Immanuel Silaban)

147	Women and mental health	ABS-23
The Impact of Marpaniaran traditional Dance of Women of Toba Batak Wedding Ceremony for Womens Health Yessy Octavianna (a), Robert Sibarani (b*), Hamzon Situmorang (b), Namsyah Hot Hasibuan (b) (a)Post-Graduate Department in Linguistics, Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia; (b)Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id, Abstract The purpose of this paper is to describe the benefits of marpaniaran traditional dance of women for the womens physical and mental health, the meanings and functions of marpaniaran at the Toba Batak traditional wedding ceremony. This research observed by using an anthropolinguistic approach with the analytic parameters is interconnection, valuability, and sustainability. The qualitative paradigm with the ethnography model used in this research. Marpaniaran has good benefits for womens physical and mental health. The movement performed between hands and feet require good physical health because dancing must be done well and long at the wedding ceremony. Feelings of pleasure, gratitude, and welfare of women for what they receive will increase the mental health of women. There are several meanings and functions of marpaniaran, namely as a ritual worship of God and hulahula receiver party, asking for blessings from God and hulahula, and encouraging the soul of the bride in running a household. Marpaniaran requires a strong womens physical and mental health very much. The body movements and womens feelings of welfare in marpaniaran make the Toba Batak women physically and mentally healthy and strong. Keywords: Batak Women, Marpaniaran, Womens, Physical And Mental Health Share Link | Plain Format | Corresponding Author (Immanuel Silaban)

148	Women and mental health	ABS-24
Ngikat Janji Giving Dowry for Bride as Marriage Readiness Perspective in Tamiangs Wedding Ceremony Tradition Halimatussakdiah (a), Robert Sibarani (b*) (a)Postgraduate Department in Linguistics, Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia; (b)Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id Abstract This study aimed to find the cultural performances which can apply to keep physical and mental health for women in Tamiangs wedding ceremony tradition. This research employed the ethnography method. As ethnographic research, the data were collected through depth, open-ended interview, direct participatory observation, focus group discussion which is often abbreviated as FGD and written documents. In-depth and open-ended interviews were applied to obtain data from the informants who understand Tamiangs wedding ceremony tradition, especially on Ngikat Janji and also the terms. The focus of analysis is on performance, indexicality, and participation as components of linguistic anthropology. The performance of Ngikat Janji as part of Tamiangs wedding ceremony tradition means the way to honor women of their marriage readiness. Marriage readiness is an important mental indicator for the bride and through it also to keep physical of the bride, especially reproduction health because every bride who has Ngikat Janji no more relationships with other men like dating. It indicates the honor concept contained in the tradition. Honor concept represented the physical and mental health of women brides in Tamiangs ethnicity is an important indicator to build up a quality life. Keywords: Tamiangs wedding ceremony tradition, marriage readiness, honor concept Share Link | Plain Format | Corresponding Author (Immanuel Silaban)

149	Women and mental health	ABS-25
The Tradition of Markobar in Mangalap Boru Picking a Bride as Advice for the Women Mental Health in Mandailing Wedding Ceremony Tuti Ariani Nasution(a), Robert Sibarani(b*), Syahron Lubis(b), Eddy Setia(b) (a)Postgraduate Department in Linguistics, Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia; (b)Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id Abstract The study was conducted to explain the role of markobar (speech) in mangalap boru toward the bride (specifically) and women (generally) mental health in Mandailingnese. This study concerned with explaining the phenomenon of using language used to console and strengthen the bride who will move into the grooms house. This study used the ethnography model. The data were taken using a recording, interview, and observation. The steps in markobar of mangalap boru were analyzed based on its structure and explaining the speech that consists of advice for the bride. Markobar in mangalap boru produced the utterances to advise the bride to face her new situation with her grooms big family. The speech consists of an introduction by telling the steps of knowing the bride. It was then continued by a speech of accepting the bride to the grooms big family and advice from both sides. It is covered by giving speeches of requests from the brides family to take care of their daughter and promise from the grooms family. Tradition markobar in mangalap boru affected the brides mental health to release her life custom with her family and move forward with her new with her husband. The pieces of advice in markobar strengthen her spirit and mental to accept the new situation and adapt it sincerely. The language used and performance in delivering markobar is Mandailing local wisdom that should be maintained toward an agreed life system in Mandailingnese. Keywords: Mental health, women, markobar, mangalap boru , Mandailing Share Link | Plain Format | Corresponding Author (Immanuel Silaban)

150	Women and mental health	ABS-44
Marriage satisfaction of women in South Sulawesi during the COVID-19 pandemic: a descriptive study Andi Tenri Pada Rustham, Andi Juwita Amal Department of Psychology Medical Faculty Hasanuddin University Abstract Marital satisfaction is a psychological condition that a couple needs to navigate their household ark. Domestic harmony which then affects the couples decision to stay or divorce in marriage is largely determined by the satisfaction of their marriage. Several studies have shown that marital satisfaction is the psychological condition that most determines the psychological well-being of women in their married life. This study aims to find out how the level of marriage satisfaction of women in South Sulawesi during the Covid 19 pandemic. The uncertain socio-economic situation caused by the outbreak, most likely affects the level of their marriage satisfaction. 135 South Sulawesi women were involved as respondents in filling out the questionnaire. The data obtained were analyzed using descriptive analysis techniques using SPSS. The results showed that the marriage satisfaction level of South Sulawesi women during the pandemic tended to be low. Of the 135 respondents, 66% were in the low level of satisfaction category, 23% were in the medium category, and the remaining 11% were in the high category. Keywords: marriage satisfaction, COVID-19 pandemic, South Sulawesi women. Share Link | Plain Format | Corresponding Author (Andi Tenri Pada Rustham)

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