Clinicopathological factors of stage IB-IIB cervical cancer following neoadjuvant chemotherapy relevant to intraoperative bleeding and transfusion, ICU admission and length of stay Nurkamilawati Arista (a*), Nugraha Utama Pelupessy (b), Rudy Butje Leonardy (a), Firdaus Hamid (c), Sharvianty Arifuddin (b), Susiawaty (a)
a)Department of Obstetrics and Gynecology, Faculty of Medicine Hassanuddin University, Makassar 90245, Indonesia
*nurkamilawati.arista[at]gmail.com
b)Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hassanuddin University, Makassar, Indonesia
c)Department of Microbiology, Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia
Abstract
Objective : To compare the efficacy of NACT followed by surgery with surgery alone in cervical cancer stage IB-IIB.
Method : Forty-three cervical cancer stage IB-IIB were included in this study. Platinum-based chemotherapy were performed three or six cycles consisted of intravenous paclitaxel (175 mg/m2) and cisplatin (50 mg/m2) or carboplatin (300-400 mg/m2 ) with 3 weeks interval followed by surgery in first group (24 respondents) and primary surgery in second group (19 respondents).
Result : Analytical test results showed levels of leukocytes (p = 0.002) and platelets (p = 0.001) were lower in the NACT group. Intraoperative bleeding (627.08 ml vs 605.26 ml) and intraopoerative transfusion (8 vs 6 ) were higher in NACT Group. Positive LVSI was obtained 25% vs 57.89% , tumor sizes were significantly smaller in NACT group (p <0.001).
Conclusion : NACT administration increase operability and improve pathologic prognostic factors, ,but increases of hematological side effect and intraoperative complication
Keywords: Cervical cancer stage IB-IIB, NACT, Clinicophatological factors
