Expression Of Protein Regenerating Liver-3 (PRL-3) and E-Cadherin: Close Correlation With Metastatic Breast Cancer Upik Anderiani Miskad1, Syakir2, Daniel Sampepajung2, Irawan Yusuf2
1Department of Pathology, Faculty of Medicine, Hasanuddin University, Makassar
2 Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
*upik.miskad[at]gmail.com
Abstract
Objective: Breast cancer is the most common malignant neoplasm worldwide. PRL-3 (protein regenerating liver-3/PTP4A3) was reported participates in the progression and metastatic of various cancer including breast cancer. Recently PRL-3 was suggested to promote epithelial mesenchymal transition (EMT) by downregulating E-cadherin expression. To clarify the molecular mechanisms that involved in breast cancer progression and metastasis, we investigate the expression of PRL-3 and E-Cadherin and correlate the expression with the clinicopathologic parameters.
Methods: Expressions of PRL-3 and E-Cadherin in 114 primary breast cancer specimens and 73 limphonode metastasis were detected by immunohistochemistry.
Results: Among primary breast cancers examined, there were 11 (9.6%) low grade, 70 (61.4%) moderate grade and 33 (28.9%) high grade malignancy. There were significant correlation between PRL-3 expression and histological grading of breast cancer (p=0.044) and the presence of lymphonode metastasis (p<0.001). The significant correlation was also found between expression of E-cadherin and the presence of LN metastasis (p=0.001). The expression of PRL-3 in primary site was significantly correlated with metastatic site (p<0.001). The result showed that the more higher PRL-3 expression the more lower the expression of E-cadherin in breast cancer.
Conclusions: These results strongly suggest that PRL-3 play a role in the progression and metastasis of breast cancer. PRL-3 may down regulate the expression of E cadherin and induce metastatic ability in breast cancer.
Keywords: Key words: PRL-3, E-Cadherin, Breast cancer metastasis, Immunohistochemistry
