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61	Maternal, neonatal, and child health	ABS-115
Management of Covid-19 in Pregnant Women and Neonates Suhartina Hamzah (a*), Ainun Fatimah (b), Iqra Aswad (c), Kurniaty (d) a) Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia *suhartinahamzah[at]unhas.ac.id b) Faculty of Cultural Sciences, Hasanuddin University, Makassar, Indonesia c) Faculty of Engineering, Hasanuddin University, Makassar, Indonesia d) Graduate School, Hasanuddin University, Makassar, Indonesia Abstract Coronaviruses are a large family of viruses that cause disease in humans and animals. In humans, it usually causes respiratory infections, from the common cold to serious illnesses such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). The disease is mainly spread between people through respiratory droplets from coughs and sneezes. This virus can last up to three days with plastic and stainless steel SARS CoV-2 can last up to three days, or in aerosols for three hours. The management of Covid-19 is based on the classification of the severity of cases, which are divided into several groups, namely without symptoms, mild symptoms, moderate symptoms, severe and critical symptoms. Changes in the immune system that occur in pregnancy can make pregnant women more susceptible to Corona virus infection and more at risk of experiencing severe and fatal symptoms of disease. In addition, the high fever that occurs due to COVID-19 in the first trimester of pregnancy can increase the risk of birth defects in children. Pregnant women with SARS or MERS are also at higher risk of experiencing miscarriage or giving birth to premature babies. This incident can also occur in pregnant women with COVID-19, COVID-19 is a new disease that has become a pandemic. This disease should be watched out for because transmission is relatively fast, has a mortality rate that cannot be ignored, and there is no definitive therapy. There are still many knowledge gaps in this field, so further studies are needed. Keywords: Covid19; Neonates; Pregnant Women Share Link | Plain Format | Corresponding Author (Ainun Fatimah)

62	Maternal, neonatal, and child health	ABS-118
EATING HABITS AND HISTORY OF HYPEREMESIS GRAVIDARUM AS RISK FACTOR OF PREECLAMPSIA Nurmiaty1*, Melania Asi1, Sitti Aisa1, Halijah1, Yustiari1 Department of Midwifery, Polytechnic of Health Ministry of Health, Kendari, Indonesia Abstract Objective: This study aimed to determine the relationship between eating habits and hyperemesis gravidarum with the incidence of preeclampsia. Method: This study used a cross-sectional design. The total sample was 48 pregnant women with normal pregnancy and preeclamptic pregnancies who had a gestational age above 20 weeks. Collecting data using a questionnaire and data analysis using the chi-square test and odds ratio (OR). Results: The habit of eating irregular fruit during pregnancy was significantly associated with the incidence of preeclampsia, with an OR value of 8.57. Mothers who had hyperemesis gravidarum increased their risk 3.86 times for developing preeclampsia. Conclusion: Eating habits and history of hyperemesis gravidarum as risk factor of preeclampsia. Nutritional intervention is needed through nutrition education for pre-pregnant women so that their nutritional adequacy during pregnancy can be fulfilled, especially during the 1st trimester, namely the implantation phase and socialization of the community movement program for healthy living, especially the consumption of vegetables and fruits for women of childbearing age, women during pre-pregnancy, pregnant and breastfeeding. Keywords: KEYWORDS: Preeclampsia, Hyperemesis gravidarum, Fruit, and Vegetable Eating Habits. Share Link | Plain Format | Corresponding Author (Nurmiaty Nurmiaty)

63	Maternal, neonatal, and child health	ABS-138
Antenatal Sonographic Diagnosis of Alobar Holoprosencephaly With Associated Cyclopia and Proboscis Ricky Eko Januar Silaen (a*), Hasnawaty (b), Deviana Soraya Riu (a) Abstract Background: Holoprosencephaly is also known as brain malformation caused by prosencephalon splitting failure in the first four weeks of embryogenesis. This abnormality occurs 1: 250 during the phase of embryogenesis and 1 : 16000 in alive newborns. The Purpose: to provide an overview of antenatal ultrasonography in holoprosencephaly disorders The Case: We are reporting one case, a 38-year-old mother with G4P3A0 gravid 31 weeks and two days with a single fetus. During the ultrasound examination, polyhydramnios amniotic fluid was found, undeveloped brain organ of falx cerebral, thalamus, and there were also cyclopia and proboscis on the face. Vaginal delivery was conducted to deliver a baby girl weighed 1300 grams, and as showed on the ultrasound, the baby had a microcephaly head, cyclopia, proboscis, extremity, and normal genitalia. Keywords: Holoprosencephaly; Cyclopia; Proboscis; Antenatal Share Link | Plain Format | Corresponding Author (Ricky Eko Januar Silaen)

64	Maternal, neonatal, and child health	ABS-143
Treacher Collins Syndrome: A Case Report Andi Rahmayanti (a*), Nur Rakhmah (b), Deviana Soraya Riu (c), Anandha Mardiah Prefitri (c) a) Obstetric and Gynecology Department Hasanuddin University, Makassar - Indonesia *andirahmayanti[at]gmail.com b) Obstetric and Gynecology Department, Social Obstetric and Gynecology Division Hasanuddin University, Makassar - Indonesia c) Obstetric and Gynecology Department, Maternal Fetal Division Hasanuddin University, Makassar - Indonesia Abstract Treacher Collins Syndrome is a rare genetic abnormality marked by craniofacial deformity. TCS incidence ranged around 1 from every 50.000 live births. This dominant autosomal abnormality was caused by genetic mutation, especially TCOF1 gene. Around 60% of the TCS cases happened due to de novo gene mutation, so there was no history of same disease found within the family. At the 2nd trimester antenatal visit, patient was suspected having congenital abnormality from ultrasound screening. We may found above normal amnion fluid / hydramnios, enlarged septum pellusidum, and a few other deformities on face and head suggesting there were intrauterine congenital abnormalities. Prenatal genetic examination is needed to diagnose TCS, but TCS that was found on the 2nd trimester ultrasound screening can help us to make better counseling for the families. TCS treatment depends on the abnormality found, but multidisciplinary therapy is usually required. Keywords: Treacher Collins Syndrome; Congenital Abnormality Share Link | Plain Format | Corresponding Author (Andi Rahmayanti)

65	Maternal, neonatal, and child health	ABS-144
High Caesarean Delivery According to Risk of Hypertension Related Pregnancy and Robsons Classification in One of Mother and Children Hospital in Makassar Angeline Rumintjap, Maisuri Chalid, Deviana Riu Department of Obstetrics and Gynaecology, University of Hasanuddin Makassar, Indonesia Abstract Objective: The study aimed to describe the relationship between hypertension related pregnancy and methods of delivery also analyse the caesarean delivery based on Robsons classification. Methods : Descriptive study with cross-sectional design over 1 year period (December 1st 2018 to November 30th 2019) of 156 women with hypertension related pregnancy delivered in Sitti Khadijah 1 Mother and Children Hospital in Makassar, Indonesia. Risk factors, clinical manifestation, classification of hypertension, birth weight, 1-minute APGAR score and method of delivery were collected and analysed with Chi-square. Results : Caesarean delivery was 87.8% in our study and birth weight is significantly related to method of delivery (p=0,018). According to Robsons classification, size of group 8 (5.8%), group 10 (9%) and number of caesarean delivery in group 5 (90%) were higher (should be 1.5-2%; <5%; and 50-60%, respectively). Conclusion : Evaluation with Robsons classification is needed for hypertension related pregnancy. Keywords: Hypertension; Pregnancy; Caesarean delivery; Robsons classification Share Link | Plain Format | Corresponding Author (Angeline Francis Rumintjap)

66	Maternal, neonatal, and child health	ABS-155
Asymptomatic Urinary Tract Infection in Pregnant Women attending Public Health Centres in Makassar 2020 Rizalinda Sjahril (a, b*), Dini Mutia Khairunnisa (a), Ahmad Dzaki Aditya (a), Ridha Wahyuni (a), Yuliani Ridwan (b), Sadyah Sadyah (b), Syafri Syafri (a) UNHAS Abstract Background. Asymptomatic urinary tract infection is important to identify amongst pregnant women because of its potential to cause adverse maternal and foetal outcome. However, information on such prevalence based on urine culture in Makassar is currently not available. The aim of this preliminary study was to determine the prevalence and significance of bacterial agents as the causative agent of asymptomatic urinary tract infection. Methods. Mid stream urine of pregnant women attending the public health centres in Makassar who admits no urinary symptoms were collected. Using semiquantitative method urine was streaked in Blood Agar and MacConkey Agar Plate and incubated at 35oC in aerobic condition. Bacterial colony count was performed after 24 hours of incubation. Asymptomatic bacteriuria refers to the presence of bacterial colonies of the same type of more than 105 CFU/mL. Results. Between August - September 2020, 67 urine specimens were collected and processed for bacterial culture, among which 3 (4.5%) samples fulfilled the criteria of urinary tract infection. The bacteria identified were Pantoea spp (1.5%), Pseudomonas aeruginosa (1.5%) and Staphylococcus epidermidis (1.5%). All study subjects were pregnant between 8-12 weeks. Conclusion. This preliminary study on asymptomatic urinary infections in pregnant women in Makassar revealed that routine screening based on bacterial culture among pregnant women is required to be able to identify the causative agent and further determining the appropriate antibiotic therapy. Keywords: asymptomatic; urinary tract infection; pregnant; women Share Link | Plain Format | Corresponding Author (Rizalinda sjahril)

67	Maternal, neonatal, and child health	ABS-157
Increasing Midwifery Capability on Maternal Health Service Risnah (a*), Ridwan Amiruddin (b), Mustamin(c), Muhammad Irwan (d), Musdalifah Mukhtar (e), Nurhidayah (e), Nurul Fadillah Gani (e), Eka Hadrayani (e), Muthahharah (e), Eva Yustilawati (e) (a) Nursing Department, Faculty of Medicine and Health Sciences of Alauddin Islamic State University (b) Professor, Faculty of Public Health, Hasanuddin University, Indonesia (c) Staff, Jeneponto District Health Office, South Sulawesi, Indonesia (d) Nursing Department, Health Faculty, Universitas Sulawesi Barat, Indonesia (e) Nursing Department, Faculty of Medicine and Health Sciences of Alauddin Islamic State University *risnah[at]uin-alauddin.ac.id Abstract Objective: This study aimed to determine the differences in midwives knowledge, attitudes, motivation and abilities regarding maternal health care after an intervention. Methods: This was an experimental research study with a quasi-experimental pretest-posttest design with a control group. The sample of this study was 66 midwives in Jeneponto Regency; 33 midwives comprised the control group, and 33 comprised the treatment groups. The sampling technique was purposive. This study was conducted at six Primary health care in Jeneponto Regency. Results: This study shows that there were differences between the midwives in the treatment and control groups in mean knowledge, motivation, attitude and ability regarding health care for pregnant women before and after health education (p <0.005); the increase in the service abilities of midwives after the Ammuntuli Bija intervention models indicates that the intervention is truly working. The components that showed significant changes (p <0.05) were knowledge (p = 0.024), motivation (p=0.046) and ability (p= 0.017). Conclusion: The models and modules provided were capable of increasing the knowledge, motivation and ability of midwives in maternal health care. Comprehensive efforts, cross-sector support and supporting regulations are needed. Keywords: Midwives, Maternal, Health services Share Link | Plain Format | Corresponding Author (Risnah Risnah)

68	Maternal, neonatal, and child health	ABS-160
Risk Transmission Through Breastfeeding and Antibody in COVID-19 Mother Ummu Aiman (a), Maratus Sholehah (a), Michael Grant Husein (a) Medical Student, Medical Faculty, Universitas Hasanuddin, Makassar, Indonesia Abstract Objective: SARS CoV 2 has spread beyond the world and make a new challenge in the breastfeeding issue. There is some disagreement among breastfeeding management in confirmed COVID 19 patients China consensus but no evidence shows the transmission via breastfeeding. This paper aims to know the risk of transmission through breastfeeding in COVID 19 patients and antibodies in breastmilk. Method: We conducted a literature review of publicly available information to summarize knowledge about risk transmission through breastfeeding and antibody in mother confirmed COVID 19 Result: A maternal woman was positive for COVID 19 in throat swabs show negative SARS CoV 2 in breastmilk. No evidence suggests the transmission of SARS CoV 2 from mother to baby via vertical route or breast milk. IgG and IgA were detected in breast milk and potentially against SARS CoV 2. Conclusion: Mother with COVID 19 can continuing direct breastfeeding with appropriate hygiene precautions (using a mask and wash hand) and should remain separate (home isolation precautions) from other family members including the infant, except for breastfeeding. Keywords: COVID-19, Breastfeeding, Antibodies Share Link | Plain Format | Corresponding Author (Ummu Aiman)

69	Maternal, neonatal, and child health	ABS-166
Dietary diversity, dietary patterns and dietary intake are associated with Stunted Chidlren in Jeneponto District, Indonesia Hasan Basri (1) Veni Hadju (2), Andi Zulkifli (3), Aminuddin Syam (2) 1 Doctoral student in Nutrition Science, School of Publlic Health, Hasanuddin University,Makassar. 2 Departement of Nutrition Science, School of Publlic Health, Hasanuddin University, Makassar. 3 Departement of Epidemiology, School of Publlic Health, Hasanuddin University, Makassar. Abstract Background The most influence of occurrence children stunted are those related to food, both in terms of quantity and quality. The good food was having food diverse and fulfills adequate nutrition according to age and sex of the child. The aim of this study is seeing of the relationship between dietary diversity, dietary pattern and dieatry intake for children stunted. Method This study is a follow up of the previous study of nutrition interventions in children, where the total sample size chidlren was 340 measured the dietary intake with 24-hour recall. the dietary diversity and dietary patterns was measured by the FFQ (Food Frequency Questioner) form for children. Stunted was defined as <-2 height for age z score, calculated by WHO anthro 2005. The data was using the chi-square test and independent t-test by the SPSS 25 application. Results The results showed that a lack of energy intake associated with children stunted was 132 (44.9%) (p = 0.050), and the same was true for children lacked fat intake was 125 (45.6%) (p <0.050). The dietary diversity was measured based number of types of food consumption, there is a relationship with stunted at a mean value of 7.51&#61617;0.87 (p <0.050). As for the dietary pattern was measured based the level adequacy of childrens food frequency, there is a relationship between insufficient of consumption nuts and stunted (p = 0.019) and foods containing sugar (p = 0.050) also, namely 135 (45.3%) and 103 (43.8%). Conclusion Stunted children under 5 years of age is related to childrens diet, not only in terms of food quantity like dietary pattern but also in terms of quality like providing a variety of foods. Accordingly, the amount of childrens dietary intake can be fulfilled according to the adequate of recommended nutrition. Keywords: Diversity, Pattern, Food, Stunted Share Link | Plain Format | Corresponding Author (Hasan Basri)

70	Maternal, neonatal, and child health	ABS-168
Evaluation of health care quality among insured patients in Indonesian mother & child hospital: A secondary data analysis Rini Rachmawaty (a*), Andi Wardihan Sinrang (b), Elly Wahyudin (c), Agussalim Bukhari (b) a) Faculty of Nursing, Hasanuddin University, Makassar, Indonesia, TNR Building, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, South Sulawesi, Indonesia. *rini.rachmawaty[at]unhas.ac.id b) Faculty of Medicine, Hasanuddin University, Makassar, Indonesia. c) Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia. Abstract Objective: This study aimed to evaluate the health care quality among insured patients hospitalized in the Indonesian mother and child hospital. Method: A secondary data analysis was performed to evaluate the health care services received by the insured patients hospitalized in the Indonesian mother and child hospital. Data were extracted from the BPJS health insurance e-claim database from January 1 to December 31, 2019 and from January 1 to June 30, 2020. A descriptive and bivariate analysis were used to examine total patients and hospital admissions, patient diagnoses and severity, types of inpatient wards, length of stay, discharge status, hospital costs, and 30-day readmissions. Results: Total inpatient unit admissions were 2,870 in 2019 and 1,533 in 2020. From total hospital admissions in 2019 and 2020, over 50% were admitted to the 3rd class of inpatient units, less than 10% had length of stays more than 5 days, and over 98% were discharged based on physician approval. However, hospital readmissions were also found for about 20.1% in 2019 and 2.9% in 2020 and about 42.9% in 2019 and 61.3% in 2020 were found causing hospital financial losses. Older patients, longer hospital stays, inpatient ward class 1 & 2, high hospital tariff, inadequate clinical pathway implementation, lack of interprofessional collaboration, and ineffective nurse manager supervision were identified as contributing factors to the hospital financial losses. Conclusion: Integrated clinical pathways with interprofessional collaboration that are implemented through professional nursing practice model are suggested for health care quality improvement. Keywords: Clinical Pathway; Health care quality; Health services research; Hospital Readmissions; Hospital Stay; Nursing Care Management; Patient Care Management. Share Link | Plain Format | Corresponding Author (Rini Rachmawaty)

71	Maternal, neonatal, and child health	ABS-170
The role of the mother s habit to clean the ears against incidence of cerum obturans in children Syahrijuita Kadir Hasanuddin University Abstract Purpose: This study aims to describe the role of the mother s habit againts incidence of cerumen obturans in children. Methods: This study is observasional analizing with cross sectional design .This study was conducted on 119 elementary students and their mother s habits at SD Kera-Kera, Makassar, Indonesia. The aged samples betwen 6-13 years, an otoscopic examination was performed to determine cerumen obturans and interview method to know ear cleaning habits. Results: In this study, it was found that 84,9% of the samples experienced obtaining cerumen in one or both ears, especially in children with aged <<10 years (71%) , where 82.4% of the ear cleaning were made by their mother, using a cotton bud or cerumen hooks with the main complaints of the children is discomfort or impaiment of hearing where these habits are not recognized by the level of education or the main activities of mothers. Conclusions: The mother s habit to clean the ears ear plays a major role in the incidence of cerumen obturans in children. The habit of cleaning the ears not see the people who do it or the frequency affects, the high incidence of cerumen obturans found in children, especially elementary school students who are under 10 years old . Keywords: mother s habit, cerumen obturans, insidens, children Share Link | Plain Format | Corresponding Author (Syahrijuita Kadir)

72	Maternal, neonatal, and child health	ABS-178
The Effect of Stability Ball Exercise on Low back pain Intensity and Functional Activity In Pregnant Women Andi Besse Ahsaniyah (a*) Nahdiah purnamasari (b) Nurul Rezky Amalia (c) a. Physiotherapy Program, Nursing Faculty, Hasanuddin University *esseahsaniyah[at]gmail.com b. Physiotherapy Program, Nursing Faculty, Hasanuddin University c. Physiotherapy Program, Nursing Faculty, Hasanuddin University Abstract Pregnancy is a period that causes many major changes in the body of woman because the growth of fetus in the womb. These changes often result in complaints of low back pain which have an impact on daily functional activity in pregnant mother such as self care, lifting, walking, sitting, standing, sleeping, sexual life, social life, and going to other place. This study aims to determine the effect of stability ball exercise on Low back pain Intensity and functional activity in pregnant mother. This study used experimental design one group pre test and post test with the type of time series research. The subjects of this study were pregnant mother with second and third trimesters in Tamalanrea and Tamalanrea Jaya public health center. The number of respondents were 13 peoples with the sampling used a purposive sampling technique. The subjects were given stability ball exercise for 4 weeks (12 times treatments). Low back pain intensity and Functional activity were measured by using the Visual Analogue Scale (VAS) and oswestry disability index (ODI). The result of the this study after used Paired T-Test and obtained a significant value p<0.001 (p<0.05) for both Low back pain intensity and Functional activity.This shows that there is an effect of stability ball exercise on Low back pain intensity and functional activity in pregnant mother. Keywords: low back pain, pregnancy, functional activity, stability ball exercise Share Link | Plain Format | Corresponding Author (Andi Besse Ahsaniyah)

73	Maternal, neonatal, and child health	ABS-179
Effect of Lumbopelvic Exercise on Functional Activity for pregnancy-related low back pain Andi Besse Ahsaniyah (a*), Haslia(b), Andi Rahmaniar (c) a) Physiotherapy Study Program, Faculty of Nursing, Hasanuddin University *esseahsaniyah[at]gmail.com b) Physiotherapy Study Program, Faculty of Nursing, Hasanuddin University c) Physiotherapy Study Program, Faculty of Nursing, Hasanuddin University Abstract Pregnancy has a profound physiological effect causing complaints during pregnancy. Low back pain is the most common complaint during pregnancy which has a negative impact on daily activities such as when walking, lifting objects, climbing stairs, doing household chores, even while resting and sleeping. Handling the limitations of functional activities can be done by providing exercise through the approach of managing low back pain. This study aims to determine the effect of lumbopelvic exercise on functional activity in pregnant women with low back pain in the Sudiang Raya Health Center. This research is a quasi-experimental design research with experimental time-series design research methods. Sampling using a purposive sampling technique with a sample of 14 people. Subjects were given lumbopelvic exercise for 6 weeks (18 treatments). Functional activity was measured using a oswestry disability index (ODI). The collected data was tested for normality using the Shapiro Wilk test and obtained normally distributed data. Then the difference test between pre test and post test using repeated measure ANOVA test. From the analysis results obtained significance value p<0,001 (p <0.05) after 18 treatments. This shows that there is an effect of lumbopelvic exercise on the functional activities of pregnant women with low back pain in the Sudiang Raya Health Center. Keywords: Low back pain, functional activity, pregnancy, lumbopelvic exercise, oswestry disability index (ODI) Share Link | Plain Format | Corresponding Author (Andi Besse Ahsaniyah)

74	Medicinal plants and natural products	ABS-26
Herbal Medicines for Women and Childrens Health in Tipang Village, District Humbang Hasundutan, North Sumatera Open Gerhad Siahaan(a), Robert Sibarani(b*), Suwardi Lubis(b), Agus Purwoko(b) a)Study program of Regional Planing, Universitas Sumatera Utara b*)Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia b)Faculty of Social Politics, Universitas Sumatera Utara, Indonesia b)Faculty of Forestry, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id Abstract This study aimed to describe the use of medicinal plants for the health of mothers and children, and to describe the local knowledge in traditional medicine to cure diseases that are often experienced by mothers and children in Tipang village, Humbang Hasundutan Regency, North Sumatra Province. This study used a qualitative method with an interactive model. The scientific approach used in this research is local wisdom. The local knowledge of the Tipang community based on local wisdom on the use of herbs in traditional medicine. Besides the local knowledge about the types of medicinal plants, they also know how to apply it to therapy, especially massage therapy. Specifically, they use this traditional medicine for the health of mothers and children, including the use of bangun-bangun leaves to increase milk production, pultak-pultak (Physalis angulata), Bulung ni untejau (guava leaves), hunik (Curcuma domestica), botik (Carica papaya), harambir (Cocos nucifera) used to treat colic, ginger are used to reduce fever in children, paet-paet leaves are used to heal wounds, and halas (Alpinia galanga), and Napuran (Betel leaf) are used to treat the itching. Traditional medicine is part of the cultural system of the Tipang village community which has huge potential benefits in developing community health, especially maternal and child health. Keywords: Herbal Medicine, Tipang, Women and Childrens Health Share Link | Plain Format | Corresponding Author (Immanuel Silaban)

75	Medicinal plants and natural products	ABS-67
Traditional Medication on the health Of Women And Children of the Togutil Tribe In North Maluku Province Zulkifli Taib (a), Robert Sibarani (b*) (a) Postgraduate Of Natural Resource Management and Environment Of North Sumatera University, Indonesia (b) Faculty of Cultural Science, Universitas Sumatera Utara, Indonesia *rs.sibarani[at]usu.ac.id Abstract Objectives: This research aimed at studying 1) Togutil tribe women and childrens health condition, and describing 2) the local wisdom of traditional medicine of women and children of the Togutil tribe. Methods: The research used ethnography study with the design of multiple sites and a tick description approach (thick description and depth). Results: Togutil women and children always rely on traditional medicine and they do this treatment since ancient times and have always been done from generation to generation. Traditional medicinal ingredients come from the leaves, stems, roots of trees, and fruit of the trees. If the medicine has been given and there is no change, the person who is sick will be taken to a doctor for consultation and recommend other traditional medicine to drink. The role of women and children of the Togutil tribe is more dominant in the home to maintaining the food security and the role of men of the Togutil tribe is outside the home to hunting and farming. Conclusion: The health of Togutil women and children is very important to maintain their survival. The pattern of maintaining their health by consuming traditional medicines Keywords: Traditional medicine, women and children of Togutil Tribe, local wisdom, North Moluccas Share Link | Plain Format | Corresponding Author (Robert Sibarani)

76	Medicinal plants and natural products	ABS-69
Cytotoxic Activities and Its Profiling of Partition Extracts from Purple Maman (Cleome rutidosperma DC.) Using 1H NMR Spectroscopy Combined with Cluster Analysis Budiman Yasir (a*), Muhammad Raihan (b), Subehan (b), Gemini Alam (b), Rosdiana Natzir (c), Abdul Rohman (d) a) Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia *budimanyasir12[at]gmail.com b) Department of Pharmacognosy-Phytochemistry Laboratory, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia c) Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia d) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta 55281, Indonesia Abstract Metabolomic studies in medicinal plants using NMR analytical instruments are useful for plant fingerprinting and exploration of biological effects in drug discovery investigation. Cleome rutidosperma DC is a herbaceous plant that grows wild and is found many in tropical areas and used as a health treatment. This study analyzed metabolite profiles in hexane extracts, petroleum ether partitioned extracts, methanol partitioned extracts, methanol-water subpartition extracts, and hexane subpartition extracts using 1H NMR combined with cluster analysis and cytotoxic activities against five human cancer cell lines were A549 (lung), KB (cervical), KB-VIN (nasopharyngeal), MD-MB-231 and MCF-7 (Breast). The 1H NMR spectrum identifies the dominant major compounds and represents the signal of saturated fatty acid compounds, omega-3 fatty acids, lipids, beta-glucose, cholesterol, ethyl, and methyl groups of each extract, and the chemical shift 0.52-9.39 ppm appears after magnified as minor compounds. Cluster analysis showed an extract similarity of 95.57% and had a positive correlation coefficient (R2) 0.92, and then hexane extract showed potential as an anticancer cell line with a cell growth inhibition value of 28.1% for MCF-7 cell and >58% for cells A549, KB, KB VIN, and MDA-MB-231 compared to other samples. Spectra 1H NMR confirms the potential of the technique in authenticating each extract with its activity correlation. Keywords: Cleomaceae, NMR, Fingerprinting, Cluster Analysis, Anticancer Cell Line Share Link | Plain Format | Corresponding Author (Budiman Yasir)

77	Medicinal plants and natural products	ABS-83
A natural product of anticancer peptides (ACPs) from symbiotic bacteria: Potential and Opportunities Nur Asmi (a), Ahyar Ahmad (a*), Hasnah Natsir (a), Muh. Nasrum Massi (b), Harishkumar Madhyastha (c), Radha Madhyastha (c), Yuichi Nakajima (c), Masugi Maruyama (c) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Hasanuddin University, Makassar 90245, Indonesia *ahyarahmad[at]gmail.com b) Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar 90245, Indonesia c) Department of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan Abstract Objective: This study was aimed to evaluate the bioactivity of the peptide from symbiotic bacteria at lung cancer LK-2 cell line compared normal M5S cell line Methods: The separation of protein hydrolyzates based on molecular weight was carried out using a Molecular Weight Cut Off (MWCO) membrane to obtain peptide fragments. Peptide fragments &#8804; 5 kDa, > 5-10 kDa, and > 10 kDa were tested for their anticancer activity using LK-2 lung cancer cells line compared to normal M5S cells line. The percentage of viable cells and cell proliferation were analyzed by MTT assay. The selectivity is determined using the Selectivity Index (SI) equation. Result: The results showed the number of deaths of LK-2 cells increased when they were treated with peptide fragments at sizes &#8804; 5 kDa, > 5-10 kDa, and > 10 kDa during the 16 hour treatment period. Peptide fragments resulted in the rate of cell proliferation were decreased at 16 h in the LK-2 cells, whereas the M5S cells did not show a significant decrease (P < 0.05) compared with control. The highest selectivity was shown by peptide fragment with a molecular weight &#8804; 5 kDa and > 5-10 kDa; the value of SI is 3. Conclusion: This discovery shows that peptide fragments that have sufficient selectivity are used as anticancer agents. This study shows the potential and opportunities of peptides from symbiont bacteria to be used as cancer therapy agents, especially lung cancer Keywords: Symbiotic bacteria, peptide fragments, ACPs, lung cancer, selectivity index Share Link | Plain Format | Corresponding Author (Nur Asmi)

78	Medicinal plants and natural products	ABS-86
Isolation and characterization of bioactive protein from several Species of sponges as antibacterial agents Harningsih Karim (a,c) Ahyar Ahmad (b*), Nur Asmi (b), Muh. Nasrum Massi (c), Andi Ilham Latunra (d) a) Department of Pharmacy, School of Pharmacy YAMASI, Makassar, Indonesia. b) Chemistry Department, Mathematics and Natural Science Faculty, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10 Tamalanrea, Makassar 90245, Indonesia. *ahyarahmad[at]gmail.com c) Department of Medicine, Faculty of Medicine, Hasanuddin University, Jl Perintis Kemerdekaan Km. 10 Tamalanrea, Makassar 90245, Indonesia. d) Biology Department, Mathematics and Natural Science Faculty, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10 Tamalanrea, Makassar 90245, Indonesia. Abstract Research on antibacterial bioactivity of protein fraction derived from various species of sponges in Barang Lompo island, South Sulawesi by using a polar solvent buffer of 0.1 M Tris-HCl with pH 8.3, 2 M NaCl, 0.01 M CaCl2, 1 % β-mercaptoethanol, 0.5 % Triton X-100 has been carried out. Lowry protein assay was performed to determine the protein concentration. The bioactivity test was analyzed using gel diffusion technique. Results have shown that the protein concentration in the crude extracts isolated from 500 g of fresh samples of four species of sponges (BLS 02, BLS 06, BLS 07, and BRL 01) was 7.080 mg/mL; 8.400 mg/mL; 16.624 mg/mL, respectively. The initial purification of protein use was carried out using the fractionation method with ammonium sulfate, followed by the dialysis process. Bioactivity against to Salmonella typhi was shown by all protein fractions, of which protein fraction with saturation level of ammonium sulfate 40-60% of BRL 01 sponge shows the highest inhibition zone (26.48 mm) followed by protein fraction with ammonium sulfate saturation level of 30-40% of BLS 06 sponge (26.18 mm).Test of the inhibition level in the various concentration of bioactive protein with the highest inhibition zone showed that the maximum activity was in 4000 μg/mL of protein from BRL 01 40-60 % and BLS 04 30-40 % with inhibition zones of 23.54 and 20.56 mm, respectively. These results indicate that bioactive protein from the sponge has great potential as a raw material for developing novel antibacterial drugs, particularly for Salmonella typhi infections. Keywords: Bioactivity, sponges, bioactive protein, antibacterial, inhibition zone Share Link | Plain Format | Corresponding Author (Nur Asmi)

79	Medicinal plants and natural products	ABS-93
Optimazation Extraction and Pre-Eliminary Cytotoxicity of Plectranthus scutellarioides Variety in Indonesia Ayun Dwi Astuti, Budiman Yasir, Gemini Alam* Postgraduated Student, Medical Faculty, Hasanuddin University, Indonesia Pharmacognosy-Phytochemistry Laboratory, Faculty of Pharmacy, Hasanuddin University, Indonesia *Correspondence author: daengta007[at]yahoo.com Abstract Objective: This study aimed to demonstrate optimization extraction and cytotoxicity of variety of Plectranthus scutellariodes, which is known as Miana Hias, as new candidate for anticancer drug. Method : This research is analytic experimental which conduct by optimization of extraction using three solvent and three extraction method, and cytotoxicity assay using brine shrimp test. Results: Optimate extraction was obtained by soxhletation with ethanol as solvent based on %yield of extract. Trailing psycholeus show the highest toxicity than color blaze dark star and trailing queen but this result was not significance (p=0.9). Only effect from extraction method has significance different p value 0.06 with significance level 0.1 (90%). Conclusion: Optimum extraction based on %yield of extract obtained by soxhletation and ethanol as solvent. Plectranthus scutellarioides var. trailing psycholeus and trailing queen exhibited similar cytotoxicity, and more toxic than color blaze dark star variety, which is common use as traditional medicine at Indonesia. This result gave us new insight that trailing psycholeus and trailing queen not only used as decorative plant but also behind their beauty they have capability to be medicine. Keywords: Plectranthus scutellarioides; cytotoxicity, variety Share Link | Plain Format | Corresponding Author (AYUN DWI ASTUTI)

80	Medicinal plants and natural products	ABS-109
Hepataprotector Activity of Ethanol Extract Red Dragon Fruit (Hylocereus polyrhizus) Against Acute Hepatotoxicity of Paracetamol in Rats (Rattus norvegicus) Sustrin Abasa1, Yulia Yusrini Djabir1,2*, Peter Kabo3, Mutmainah Arif1 1. Graduated School, Hasanuddin University, Indonesia. 2. Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Indonesia. 3. Departement of Pharmacology, Faculity of medicine, Hasanuddin University, Indonesia. Abstract Objective: This study aims to look at the effect of hepatoprotector from ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) on SGOT and SGPT levels in rats (Rattus norvegicus) induced by Paracetamol. Methods: This research was conducted in an experimental laboratory using the Pre post test only control group design method. Results: The result showed that there were differences in changes in SGOT and SGPT blood measurements between groups during the treatment. However, based on the results of the one way ANOVA test, there was no significant difference between groups (p more than 0.05). ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) could not prevent significant increase on SGOT levels in rats induced by high dose of paracetamol. Whereas the measurement of SGPT levels in the ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) can prevent elevated levels of SGPT in rats induced by high-dose paracetamol, but not statistically significant. Conclusion: The ethanol extract of the red dragon fruit peel (Hylocereus polyrhizus) was visible showed improvement in the results of liver histopathological measurements in rats induced high doses of paracetamol. Keywords: Red dragon fruit peel; Hepatoprotector; Paracetamol Share Link | Plain Format | Corresponding Author (Sustrin Abasa)

81	Medicinal plants and natural products	ABS-110
Cytotoxic Activity of Ethanol Extract Moringa Leave (Moringa oleifera) and Ethanol Extract Papaya Leave (Carica papaya) Combination on MCF-7 Breast Cancer Cells Nuni Rismayanti Nurkalbi1, Aryadi Arsyad2, Ika Yustisia3* 1. Graduated School, Hasanuddin University, Indonesia. 2. Departement of Physiology, Faculity of medicine, Hasanuddin University, Indonesia. 3. Departement of Biochemistry, Faculity of medicine, Hasanuddin University, Indonesia. Abstract Objective: This study aims to find out cytotoxic activities of the combination of ethanol extract moringa leave and ethanol extract papaya leave on the growth of MCF7 breast cancer cells culture. Methods: This research was conducted in a true experimental laboratory using post test only control group design method. Results: The results showed that there were similarities in the percentage of living cells in MCF7 cell culture using a combination of Moringa leaf ethanol extract and papaya leaf ethanol extract with concentrations of 0, 20, 40, 80 and 160 microgram/mL for 48 hours with a cell density of 5 x 103 after giving WST reagent and FITC v annexin kit reagent, namely a decrease in the number of living cells in several types of extract combinations and their concentrations. Inhibition of MCF7 cell culture was also indicated by the IC50 value which was included in the very strong category with details of each extract combination for 25:75 the IC50 value is 8.09 microgram/mL, for 50:50 the IC50 value is 12.02 microgram/mL, and for 75:25 the IC50 value is 24.40 microgram/mL. However, based on the results of the one way ANOVA test, there was no significant difference between groups (p more than 0.05). Conclusion: The combination extract of ethanol extract moringa leave and ethanol extract papaya leave was inhibited the process of the MCF-7 cell culture growth showed by decrease the percentage of living cells. Keywords: Extract combination; Cytotoxic; MCF7 Share Link | Plain Format | Corresponding Author (Nuni Rismayanti Nurkalbi)

82	Medicinal plants and natural products	ABS-117
Chia Seed (Salvia Hispanica L) Extract Improves Bone Density in Ovariectomy-Induced Osteoporotic Rat Model Zulfiyah Surdam1,2, Yulia Yusrini Djabir2,3, Aryadi Arsyad2,4* 1. Graduate School, Hasanuddin University, Makassar, Indonesia 2. Department of Anatomy, Faculty of Medicine, Muslim University of Indonesia, Makassar, Indonesia 3. Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia 4. Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia Abstract Estrogen deficiency may trigger a reduction in bone density leading to osteoporosis. Chia seeds contain high phytoestrogens and calcium, both play an important role in the process of bone remodeling This study aimed to determine the effect of chia seeds (Salvia Hispanica L) on osteoporosis based on bone histological features and blood calcium levels. Twenty-five female Wistar rats were employed in the study. Two groups consisted of non ovariectomized rats with or without chia seed extract treatment. The other three groups undergone ovariectomy and then received either placebo, chia seed extract, or sodium alendronate treatment as a standard treatment for osteoporosis. Treatments were given daily through oral gavage (130 mg/kg) for 60 days. After 24 hours from the last treatment, blood samples were taken to measure the calcium levels and the tibia bone tissues were removed to perform a histological study. The results indicate the trabeculae of the ovariectomized rats were thinning. Chia seed extract treatment led to more compact trabeculae compared to those untreated or received sodium alendronate. The blood calcium levels of the ovariectomized rats treated with Chia seed were significantly lower compared to the non ovariectomized controls (p equal 0.006), but they were still within the normal range. It is concluded that chia seeds extract administration can improve osteoporosis in the ovariectomized rats Keywords: Osteoporosis; ovariectomy; tibial trabeculae; blood calcium levels Share Link | Plain Format | Corresponding Author (Yulia Yusrini Djabir)

83	Medicinal plants and natural products	ABS-140
Isolation and the potential of bioactive protein from microsymbiont red algae Eucheuma cottonii as an antibacterial agents Marinda (a*,#), Ahyar Ahmad (b, c*,#), Hasnah Natsir (b), Abdul Wahid Wahab (b), Nunuk Hariani Soekamto (b), Siti Fausiah (b), Yusriadi (a), Rafsanjany Ramadan (a), Harningsih Karim (d) a)Master Program, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Biochemistry Lab., Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia *marinda.nr[at]gmail.com b)Department of Chemistry, Mathematics and Natural Sciences Faculty, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia c)Laboratory of Research Centre and Developing of Sciences, Faculty of Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia *ahyarahmad[at]gmail.com d)Department of Pharmacy, School of Pharmacy YAMASI, Mapala 2 Street Blok D5 No.10 Makassar 90222, Indonesia. Abstract Objective:The research of the potential of bioactive protein from microsymbiont red algae Eucheuma cottonii as an antibacterial has been carried out. This study aimed to know the antibacterial activity of bioactive protein from microsymbiont red algae. Methods:The methods of research were fractionation, dialysis, and antibacterial activity test. The isolation of bioactive protein used ammonium sulphate fractionation method at the rate of 0-20%, 20-40%, 40-60%, and 60-80% percent saturation. Furthermore, the purification of bioactive protein was conducted by dialysis with a cellophane membrane. Antibacterial activity test using the agar diffusion method with testing bacterial against Staphylococcus aureus and Escherichia coli. Results:The result showed that the most of inhibition zone towards S. aureus and E. coli showed that the fraction of 60-80 % saturation with a value of 13.20 mm and 10.66 mm, respectively. Conclusion:The all of fraction have an inhibition zone towards the bacterial test. Keywords: Antibacterial, Bioactive protein, E. cottonii, Microsymbiont Share Link | Plain Format | Corresponding Author (Marinda -)

84	Medicinal plants and natural products	ABS-141
Purification, characterization, and anticancer assay of L-asparaginase enzyme from siam weed (Chromolaena odorata Linn) leaves against LK-2 lung cancer cells Yusriadi (a*,#), Ahyar Ahmad (a,b*,#), Rugaiyah A. Arfah (b), Hasnah Natsir (b), Nurul Khaerah (a), Nur Asmi (a), Nada Pratiwi Papriani (a), Marinda (a), Andi Fikrah Aulia Pamenta(a), Rafsanjany Ramadan (a), Harningsih Karim (c) a) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Biochemistry Lab., Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia b) Laboratory of Research Centre and Developing of Sciences, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia 3) Department of Pharmacy, School of Pharmacy YAMASI, Mapala 2 Street Blok D5 No.10 Makassar 90222, Indonesia *Email: ahyarahmad[at]gmail.com and yusri5077[at]gmail.com #authors with equal contribution to this work Abstract Objective: L-asparaginase enzyme is known to be isolated from siam weed (C. odorata L.) leaves and also potentially to be developed as an anticancer treatment. This research aims to characterize, purify, and test the anticancer activity of the L-asparaginase enzyme krom C. odorata L. leaves against LK-2 cancer cells. Methods: The enzyme activity was observed by Nessler Method, the enzyme purification was conducted by the chromatography techniques, and the cytotoxicity assay was observed by the MTT method. Results: The optimum conditions of enzymes effectively at pH 8, 37oC and 30 minutes whereas the effect of the addition of metal ions namely K as the best activator able to increase 8.57% of enzyme activity while Zn as the best inhibitor capable of inhibiting 85.62% enzyme activity. The pure enzyme was obtained a specific activity of 11.25 IU/mg with 67.03 times of purity levels and the enzyme molecular weight of 11.8 kDa while the IC50 values were obtained at 100.3 ppm in the medium category. Conclusion: These results indicate that the pure L-asparaginase enzyme isolated from C. odorata L. leaves has the potential to be expanded as an anticancer medicine, especially for LK-2 lung cancer. Keywords: KEYWORDS : Anticancer, C. odorata L., characterization, LK-2, purification Share Link | Plain Format | Corresponding Author (Yusriadi -)

85	Medicinal plants and natural products	ABS-142
Invitro Study of Bioactive Protein from Red Algae Symbiont Bacteria Eucheuma cottonii as Antibacterial and Anticancer Agent Siti Khairunnur(a), Ahyar Ahmad(a*), Rugaiyah Arfah(a), Hasnah Natsir(a), Nur Asmi(a), Desy Mardiana(a), Nabeela Nurvita(a) Departement of Chemistry, Mathematics and Natural Science, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia *ahyarahmad[at]gmail.com Abstract Objective This study aimed to determine antibacteria activity and toxicity of bioactive protein isolated from symbiotic bacteria of red algae Eucheuma cottonii. Methods Protein purification was done by fractination and dialysis, the results of purification were determined by the protein concentration using the Lowry method with Bovine Serum Albumin as standard. Antibacteria activity test by agar diffusion method, showed presence of bioactive protein compound that have inhibition ability towards the growth of pathogen bacteria such as Eschericia coli and Staphyllococcus aureus, and toxicity test by BSLT method, carried out by doing an examination of the toxicity level against Arthemia Salina. Results The results obtained showed that the symbiotic bacteria of red algae Eucheuma cottonii had the highest protein intracellular concentration in the fraction of 0-20% with strongest inhibition towards E.coli with 19.5 mm and fraction 20-40% towards S.aureus with inhibition area of 18.3 mm. Toxicity test showed intracellular protein fraction 0-20% have the highest toxicity with LC50 value of 18.298 ppm. Conclusion Symbiotic bacteria of red algae Eucheuma cottonii protein fraction has the potential to be developed as an antibacteria and anticancer agent in the future. Keywords: Protein Bioactive, Eucheuma cottonii, antibacteria, toxicity, BSLT (Brine Shrimp Lethality Test) Share Link | Plain Format | Corresponding Author (Siti Khairunnur)

86	Non-communicable diseases related to women	ABS-29
GYANT INTRALIGAMENTARY UTERINE LEIOMYOMA : A CASE REPORT Dwi Arry Wibowo1,Sharvianty Arifuddin2, Andi Nurshanty Padjalangi3 Abstract Giant intraligamentary uterine leiomyoma is very rare and can undergo degenerative changes that can pose diagnostic challenges. Hyaline degeneration is the most common type of degeneration. A 49 year old nulliparous woman came to Wahidin Sudirohusodo General Hospital with complaints of an enlarged abdomen since 8 months ago accompanied by abdominal pain intermittent. Ultrasound examination and CT Scan Abdomen showed a large mass originating from the adnexa and extending into the abdominal cavity so that it pushes the surrounding organs.Preoperative diagnosis is cystic ovarian neoplasm.The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy with complications rupture of the ureter.Histopathologic examination reveals uterine leiomyoma with extensive hyaline degeneration.Preoperative evaluation is required to determine the correct preoperative diagnosis and to assess the difficulty of the surgical procedure to be performed to avoid surgical complications. Keywords: Giant intraligamentary uterine myomas ,hyaline degeneration, total abdominal hysterectomy Share Link | Plain Format | Corresponding Author (Dwi Arry Wibowo)

87	Non-communicable diseases related to women	ABS-61
Acute Kidney Disease in Systemic Lupus Erythematosus: A Case Series Resha Dermawansyah Rusman (*), Haerani Rasyid (a**), Faridin HP (b) a) Nephrology Hypertension Division **haeraniabdurasyid[at]yahoo.com b) Rheumatology Division Departement of Internal Medicine, Medical Faculty, Hasanuddin University, Jl. Perintis Kemerdekaan KM.10, Makassar 90245, Indonesia *reshadermawan[at]gmail.com Abstract Acute kidney disease (AKD) describes acute or subacute damage and/or loss of kidney function for a duration of between 7 and 90 days after exposure to an acute kidney injury (AKI) initiating event. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, most commonly in women, involving the skin, kidneys, joints, heart, and serosal surfaces. We report two cases AKD in SLE. First, 21 years old female with decreased glomerular filtration rate (GFR) 31,5 for 4 weeks and renal biopsy membranous nephropathy. Second, 22 years old female with decreased GFR 27,7 for 6 weeks with focal segmental glomerulosclerosis. Both of them were treated with intravenous methylprednisolone pulse therapy followed by oral methylprednisolone and hydroxychloroquine. Their symptoms improved, and renal functions recovered gradually. Keywords: Acute Kidney Disease; Lupus Nephritis; Systemic Lupus Erythematosus; Membranous Nephropathy; Focal Segmental Glomerulosclerosis Share Link | Plain Format | Corresponding Author (Resha Dermawansyah Rusman)

88	Non-communicable diseases related to women	ABS-76
Management Of Delayed Ureteral Injury Diagnosis After Gynecologic Surgery with Ureteroneocystostomy Technique: A Case Report Wenny Yaury(a*), Putra Rimba(a), Trika Irianta(b) (a) Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia (b) Urogynecology and Reconstructive Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Hassanudin University, Makassar, Indonesia Email : Wyaury[at]gmail.com* Abstract Background: Ureteroneocystostomy primarily used for ureteral injury in the lower third portion. Total abdominal hysterectomy is the most common cause of iatrogenic ureteral trauma during gynecologic surgery. Mostly are not identified intraoperatively but rather in the postoperative period. Clinical Case: A 53 years old married woman referred with bilateral ureteral injury due to previous total abdominal hysterectomy with bilateral salpingo-oophorectomy, complained about no urine production. Ultrasonography shows free fluid and grade 2 bilateral hydronephrosis. We performed a Ureteroneocystotomy with the Lich-Gregoire technique for bilateral ureteral reimplantation. Result: We found inadvertently ligated and laceration in the left and right distal of the ureteral. Drain and stent were placed. The duration of the operation was 200 minutes. A Foley catheter was performed for 14 days. Conclusion: The patient with ureteral injury should be evaluated and intervened at the earliest because a delayed diagnosis can worsen the prognosis. Keywords: Ureteral Injury, Ureteroneocystotomy, Lich-Gregoire ureteral reimplantation. Share Link | Plain Format | Corresponding Author (Wenny Yaury)

89	Non-communicable diseases related to women	ABS-103
Effects Of Aerobic (Low Impact) On Blood Pressure And Vascular Function In Postmenopausal Women With Stage 2 Hypertension Asbath said (a*),Mikawati Rasyid (b), Wa Ode Nova Novianti(c), Firman(d) a. STIKES Mandala Waluya Kendari jln jend AH Nasutuion No G37 Kendari Sulawesi tenggara *asbath.mw[at]gmail.com b. STIKES Panakukang Makassar Jl. Adiyaksa No.5, Masale, Kec. Panakkukang, Kota Makassar, Sulawesi Selatan c. STIKES Mandala Waluya Kendari jln jend AH Nasutuion No G37 Kendari Sulawesi tenggara d. STIKES Mandala Waluya Kendari jln jend AH Nasutuion No G37 Kendari Sulawesi tenggara Abstract Introduction. The effects of menopause are often the focus of attention as women enter old age. For example, the development of several diseases, such as hypertension. Objective. It is very important to reduce the negative impact of menopause such as hypertension, by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of aerobic (low Impact) exercise on blood pressure and Vascular function in postmenopausal women with stage 2 hypertension. Methods. 20 participants (50-60 years old) suffering from stage 2 hypertension were taken from the participants PROLANIS of the Wa Ode Buri Puskemas in Kendari. Using pre-experiment one group pretest-posttest desaign. Participants are trained 3 times / week for 1 month. Participants systolic, diastolic blood pressures and pulse were measured before exercising and after 12 exercises. The method of analysis used statistical paired sample t test. Results. There was a significant change in systolic blood pressure before exercise P = 0.000 (P <0.05) and diastolic p = 0.000 (P <0.05) as well as a significant decrease in pulse rate (7 beats / min) Conclusion. Aerobic low impact exercise causes a decrease in blood pressure while increasing the strength of heart function in postmenopausal women with stage 2 hypertension. Aerobic low impact exercise may be an effective intervention for the prevention and treatment of age-related vascular complications and post monopouse effects. Keywords: Aerobic, Blood Pressure, Vascular Function, Postmenopausal, Hypertension Share Link | Plain Format | Corresponding Author (Asbath Said)

90	Non-communicable diseases related to women	ABS-112
Oxidized Low Density Lipoprotein (Ox-LDL) Levels In Non-Diabetes Mellitus Young Adult Subjects With And Without Central Obesity Nur Hayati Fatsya (a), Uleng Bahrun (a,b), Liong Boy Kurniawan (a,b*) a) Biomedical Magister Programme, Clinical Chemistry Concentration, Graduated School, Hasanuddin University, Makassar, Indonesia. b) Departement of Clinical Patology, Faculity of medicine, Hasanuddin University, Makassar Indonesia. *liongboykurniawan[at]med.unhas.ac.id Abstract Background: This study aims to determine the levels of Ox LDL levels in non-diabetes mellitus (DM) young adult subjects with central obesity and without central obesity. It involves an oxidative modification of LDL particles. The oxidative modification of LDL particles for producing Ox LDL is the result of an imbalance between pro and antioxidants, which is exacerbated by central obesity and insulin resistance. This research was conducted in the Clinical Pathology Laboratory and Research Laboratory of Hasanuddin University Hospital (RSPTN UH) from July 2019 to October 2019. Method: This was a cross sectional research. The subjects of this research were categorized as central obesity if the mens waist size was more than 90 cm and the womens was more than 80 cm, whereas patients were categorized as non DM if fasting plasma glucose levels less than 126 mg/dL. The Oxidized Low Density Lipoprotein levels were examined by the ELISA method. The data was analysed with Mann Whitney Test statistical analysis, independent t test and Spearmans correlation test. Result: Ox LDL levels in non DM young adult subjects with central obesity and without central obesity were 571.88 more or less 199.01 ng/L and 570.00 more or less 122.23 ng/L, respectively (p equal 0.411). There was no significant correlation between Ox LDL levels with BMI (p equal 0.982, r equal 0.003), with waist circumference (p equal 0.993, r equal 0.001) and with fasting plasma glucose (p equal 0.87, r equal 0.020). Conclution: The results showed no significant difference of Ox LDL levels in non DM young adult subjects between those with central obesity and without central obesity. Keywords: Ox-LDL; Central Obesity; Adult; Atherosclerosis Share Link | Plain Format | Corresponding Author (Nur Hayati Fatsya)

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