Beta catenin and L1CAM Expressions as a Prognostic Marker in Type I Endometrial Carcinoma
Yolanda Manule1, Rina Masadah1, Berti J Nelwan1, Djumadi Achmad1, Andi Alfian Zainuddin2, Upik Anderiani Miskad1*

1Department of Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
2Department of Public Health and Community Health Science, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

Corresponding Author *upik.miskad[at]med.unhas.ac.id

Abstract

Objective: This study aimed to assess the expression of beta catenin and L1CAM with their relationship as a prognostic marker in type I endometrial carcinoma.
Methods: 49 type I endometrial carcinoma were selected by taking a stratified sampling samples from January 2017 to December 2017. We used the immunohistochemical procedure to evaluate the expression of beta catenin and L1CAM related to prognostic parameters i.e., myometrial invasion, lymphovascular invasion, and metastatic event.
Results: The statistical results revealed that there was a significant difference between beta catenin and L1CAM expressions viewed from tumor cells with the depth of myometrial invasion (> 50%), occurrence of lymphovascular invasion, and presence of metastases in type I endometrial carcinoma (p <0.05).
Conclusion: This results suggest that the tendency of overexpression of beta catenin together with L1CAM can increase the progression of tumor cells in type I endometrial carcinoma, in its ability to invade myometrium, lymphovascular invasion, and metastasis to other tissues. Our findings indicate that both of beta catenin and L1CAM are promising biomarkers for the prognosis of endometrial carcinoma.

Keywords: type I endometrial carcinoma; beta catenin; L1CAM; immunohistochemistry

Topic: Women and cancer

Plain Format | Corresponding Author (Upik Anderiani Miskad)

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