MIX GONADAL DYSGENESIS WITH DYSGERMINOMA: CASE REPORT
Nuraeni, Sriwijaya, Nusratuddin Abdullah, Sharvianty

obstetric gynecology, Hasanuddin University, Makassar, Indonesia
nuraenifk03[at]gmail.com

Abstract

Introduction: Gonadal dysgenesis is one of the common causes of primary amenorrhea. There are three histological categories of gonadal dysgenesis, including Complete Gonadal dysgenesis, Mix Gonadal Dysgenesis, and partial Gonadal dysgenesis. Dysgerminoma is a malignant tumor due to the proliferation of primitive germ cells in the ovary. Cytogenetic disorders involving all or part of the Y chromosome or MGD, especially 45,X / 46,XY are associated with dysgerminoma.

Case Report: A 19-year-old woman with complaints of never had menstruation and an enlarged stomach. Karyotyping examination showed the results of chromosomes 45, X/ 46, XY. Total Hysterectomy and Bilateral Salpingo-oophorectomy was performed. Histopathology results showed a left ovarian dysgerminoma. She was treated using adjuvant chemotherapy.

Conclusion: In gonadal dysgenesis, the presence of Y chromosome is high risk for developing gonadal tumors (50%) in genotype 46 XY. Dysgerminoma has the best prognosis of all ovarian Germ cell malignant tumor variants.

Keywords: Gonadal dysgenesis,Dysgerminoma

Topic: Women and cancer