The Role of Clinical Pathology Characteristics, CA 125 and Neutrophil-Lymphocyte Ratio as Prognostic Factors of Epithelial Ovarian Cancer Nugraha Utama Pelupessy (a*), Irma Savitri (a), Sharvianty Arifuddin (a), Syahrul Rauf (a), Joko Hendarto (b)
a)Division of Gynecologic Oncology,Departement of Obstetrics and gynecology, Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia
b) Department of community and preventive medicine,Faculty of medicine, Hasanuddin University, Makassar 90245, Indonesia
Abstract
Introduction :Epithelial ovarian cancer type 2 has the characteristic of rapid tumor growth and genetically more labile than that of type 1. CA 125 and neutrophil-lymphocyte ratio are factors that play a role in the prognosis of epithelial ovarian cancer.
Methods: This study used a retrospective cohort and survival analysis. Patient data were taken from medical records at RSUP Dr. Wahidin Sudirohusodo, Makassar and Ibnu Sina Hospital Makassar for the period 2014-2019.
Results: The sample consisted of 231 patients. The significant variables were histology (P <0.001 HR 2.64 IK 1.62-4.30) and stage (P <0.001 HR 4.44 IK 2.42- 8.14) while the levels of CA 125 (P = 0.907 HR 1.05 CI 0.48-2.31) and the neutrophil-lymphocyte ratio (P <0.364 HR 1.25 CI 0.77 to 2.02) were not statistically significant.
Conclusion: Type 2 epithelial ovarian cancer and advanced stage are the prognostic factors that most play a role in epithelial ovarian cancer.
