THE COMPARISON OF ADNEX RISK MODEL WITH RMI (RISK OF MALIGNANCY INDEX) 3 IN DISCRIMINATING PREOPERATIVE BENIGN AND MALIGNANT OVARIAN MASS Yohanes Iddo Adventa, Sharvianty Arifuddin, Syahruni Syahrir, St. Nur Asni, Syahrul Rauf, Rudy B. Leonardy
Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Abstract
Background: Ovarian carcinoma remains one of mayor problems in Oncology Gynecology. Many methods have been proposed to evaluate ovarian carcinoma risks. This study analyzes the comparison between ADNEX (Assesment of Different NEoplasias in the adneXa) Risk Model with RMI (Risk of Malignancy Index) 3 discriminating preoperative benign and malignant ovarian mass.
Methods: A comparative analytic cross-sectional study on 63 participants. Data and blood samples were taken from women with ovarian tumor diagnosis in associated hospitals. ACC, SENS, SPEC, PPV dan NPV were evaluated in both predictors and statistical analysis was performed using Chi Square to evaluate menopausal and parity status correlation.
Results: From 63 total samples, consist 40 malignant and 23 benign tumors from pathology anatomy diagnosis. Both ADNEX Risk Model and RMI 3 predict 35 malignant and 28 benign tumors. The vallue of ACC, SENS, SPEC, PPV and NPV from RMI 3 analysis (79.37, 77.5, 82.6, 88.6, and 67.9%) higher than ADNEX Risk Model (73.02, 72.5, 73.9 82.9 and 60.7%). RMI 3 correlates significantly with all menopause and parity status (p = 0.0001 for premenopause, p = 0.0054 for postmenopause, p = 0.000 for nulipara and p = 0.0046 for parity >1). ADNEX Risk Model statistically significant in all parity status and premenopause group (p = 0.0004 for premenopause, p = 0.0633 for postmenopause, p = 0.001 for nulipara and p = 0.0275 for parity >1).
Conclusion: Both predictor tools have good performance in discriminating preoperative benign and malignant ovarian mass. RMI 3 is better in discriminating preoperative benign and malignant ovarian mass than ADNEX Risk Model.
