The Profile of MICA expression in Atypical Duct Hyperplasia and Ductal Carcinoma Insitu of Breast Tumor Rina Masadah1, Nurkhairaty1, Dzul ikram1,2, Berti Nelwan1, Tarsisia Truly Djimahit1
1 Department of Pathology Anatomy, Hasanuddin University, Makassar, Indonesia;
2 Department of Histology, Muslim University of Indonesia, Makassar, Indonesia
Abstract
Introduction: Breast cancer is one of the most common cancers in women throughout the world. Its etiology and pathogenesis are complex, leads the morbidity and mortality of this disease still high until now. It has been known that breast cancer occurs from the transformation of precancerous breast tumor, so that it is important to understand the gene expression that plays a role in precancerous breast tumor such as Atypical Duct Hyperplasia (ADH) and Ductal Carcinoma Insitu (DCIS) in order to develop early detection and prompt treatment of this fatal disease.
Major histocompatibility Complex class I polypeptide-related sequence A (MICA), is a ligand of Natural Killer Group 2D (NKG2D) receptor gene that expressed by NK of T inflamation cells. MICA could be used as a marker of inflammation process in tumor cells immunosurvailance, as known that inflammation process is important pathway for precancerous cells to differentiate. In this study we analyzed the expression of MICA in ADH and DCIS tissues to elucidate its role in precancerous breast tumor.
Methods: Immunohistochemistry method using antibody of MICA had been applied to 29 of ADH and 30 of DCIS tissue samples. MICA expression was analyzed statistically to histological type of breast tumor.
Results: We found that the mean score of MICA in ADH and DCIS was 2.31 0.71 and 2.32 0.89 repectively, with no significant diferentiation statistically (p=1.00). The expression of MICA in ADH and DCIS was medium intense in all samples.
Conclusions: MICA showed positive expression in ADH and DCIS, this finding showed that MICA is play a role in breast precancer tumor.
