Optimazation Extraction and Pre-Eliminary Cytotoxicity of Plectranthus scutellarioides Variety in Indonesia Ayun Dwi Astuti, Budiman Yasir, Gemini Alam*
Postgraduated Student, Medical Faculty, Hasanuddin University, Indonesia
Pharmacognosy-Phytochemistry Laboratory, Faculty of Pharmacy, Hasanuddin University, Indonesia
*Correspondence author: daengta007[at]yahoo.com
Abstract
Objective: This study aimed to demonstrate optimization extraction and cytotoxicity of variety of Plectranthus scutellariodes, which is known as Miana Hias, as new candidate for anticancer drug.
Method : This research is analytic experimental which conduct by optimization of extraction using three solvent and three extraction method, and cytotoxicity assay using brine shrimp test.
Results: Optimate extraction was obtained by soxhletation with ethanol as solvent based on %yield of extract. Trailing psycholeus show the highest toxicity than color blaze dark star and trailing queen but this result was not significance (p=0.9). Only effect from extraction method has significance different p value 0.06 with significance level 0.1 (90%).
Conclusion: Optimum extraction based on %yield of extract obtained by soxhletation and ethanol as solvent. Plectranthus scutellarioides var. trailing psycholeus and trailing queen exhibited similar cytotoxicity, and more toxic than color blaze dark star variety, which is common use as traditional medicine at Indonesia. This result gave us new insight that trailing psycholeus and trailing queen not only used as decorative plant but also behind their beauty they have capability to be medicine.
