Oxidized Low Density Lipoprotein (Ox-LDL) Levels In Non-Diabetes Mellitus Young Adult Subjects With And Without Central Obesity Nur Hayati Fatsya (a), Uleng Bahrun (a,b), Liong Boy Kurniawan (a,b*)
a) Biomedical Magister Programme, Clinical Chemistry Concentration, Graduated School, Hasanuddin University, Makassar, Indonesia.
b) Departement of Clinical Patology, Faculity of medicine, Hasanuddin University, Makassar Indonesia.
*liongboykurniawan[at]med.unhas.ac.id
Abstract
Background: This study aims to determine the levels of Ox LDL levels in non-diabetes mellitus (DM) young adult subjects with central obesity and without central obesity. It involves an oxidative modification of LDL particles. The oxidative modification of LDL particles for producing Ox LDL is the result of an imbalance between pro and antioxidants, which is exacerbated by central obesity and insulin resistance. This research was conducted in the Clinical Pathology Laboratory and Research Laboratory of Hasanuddin University Hospital (RSPTN UH) from July 2019 to October 2019.
Method: This was a cross sectional research. The subjects of this research were categorized as central obesity if the mens waist size was more than 90 cm and the womens was more than 80 cm, whereas patients were categorized as non DM if fasting plasma glucose levels less than 126 mg/dL. The Oxidized Low Density Lipoprotein levels were examined by the ELISA method. The data was analysed with Mann Whitney Test statistical analysis, independent t test and Spearmans correlation test.
Result: Ox LDL levels in non DM young adult subjects with central obesity and without central obesity were 571.88 more or less 199.01 ng/L and 570.00 more or less 122.23 ng/L, respectively (p equal 0.411). There was no significant correlation between Ox LDL levels with BMI (p equal 0.982, r equal 0.003), with waist circumference (p equal 0.993, r equal 0.001) and with fasting plasma glucose (p equal 0.87, r equal 0.020).
Conclution: The results showed no significant difference of Ox LDL levels in non DM young adult subjects between those with central obesity and without central obesity.
Keywords: Ox-LDL; Central Obesity; Adult; Atherosclerosis
