Antenatal Sonographic Diagnosis of Alobar Holoprosencephaly With Associated Cyclopia and Proboscis
Ricky Eko Januar Silaen (a*), Hasnawaty (b), Deviana Soraya Riu (a)

Abstract

Background: Holoprosencephaly is also known as brain malformation caused by prosencephalon splitting failure in the first four weeks of embryogenesis. This abnormality occurs 1: 250 during the phase of embryogenesis and 1 : 16000 in alive newborns.

The Purpose: to provide an overview of antenatal ultrasonography in holoprosencephaly disorders

The Case: We are reporting one case, a 38-year-old mother with G4P3A0 gravid 31 weeks and two days with a single fetus. During the ultrasound examination, polyhydramnios amniotic fluid was found, undeveloped brain organ of falx cerebral, thalamus, and there were also cyclopia and proboscis on the face. Vaginal delivery was conducted to deliver a baby girl weighed 1300 grams, and as showed on the ultrasound, the baby had a microcephaly head, cyclopia, proboscis, extremity, and normal genitalia.

Keywords: Holoprosencephaly; Cyclopia; Proboscis; Antenatal

Topic: Maternal, neonatal, and child health