Hepataprotector Activity of Ethanol Extract Red Dragon Fruit (Hylocereus polyrhizus) Against Acute Hepatotoxicity of Paracetamol in Rats (Rattus norvegicus) Sustrin Abasa1, Yulia Yusrini Djabir1,2*, Peter Kabo3, Mutmainah Arif1
1. Graduated School, Hasanuddin University, Indonesia.
2. Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Indonesia.
3. Departement of Pharmacology, Faculity of medicine, Hasanuddin University, Indonesia.
Abstract
Objective: This study aims to look at the effect of hepatoprotector from ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) on SGOT and SGPT levels in rats (Rattus norvegicus) induced by Paracetamol.
Methods: This research was conducted in an experimental laboratory using the Pre post test only control group design method.
Results: The result showed that there were differences in changes in SGOT and SGPT blood measurements between groups during the treatment. However, based on the results of the one way ANOVA test, there was no significant difference between groups (p more than 0.05). ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) could not prevent significant increase on SGOT levels in rats induced by high dose of paracetamol. Whereas the measurement of SGPT levels in the ethanol extract of red dragon fruit peel (Hylocereus polyrhizus) can prevent elevated levels of SGPT in rats induced by high-dose paracetamol, but not statistically significant.
Conclusion: The ethanol extract of the red dragon fruit peel (Hylocereus polyrhizus) was visible showed improvement in the results of liver histopathological measurements in rats induced high doses of paracetamol.
Keywords: Red dragon fruit peel; Hepatoprotector; Paracetamol
