Acute Kidney Disease in Systemic Lupus Erythematosus: A Case Series
Resha Dermawansyah Rusman (*), Haerani Rasyid (a**), Faridin HP (b)

a) Nephrology Hypertension Division
**haeraniabdurasyid[at]yahoo.com
b) Rheumatology Division
Departement of Internal Medicine, Medical Faculty, Hasanuddin University, Jl. Perintis Kemerdekaan KM.10, Makassar 90245, Indonesia
*reshadermawan[at]gmail.com

Abstract

Acute kidney disease (AKD) describes acute or subacute damage and/or loss of kidney function for a duration of between 7 and 90 days after exposure to an acute kidney injury (AKI) initiating event. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, most commonly in women, involving the skin, kidneys, joints, heart, and serosal surfaces. We report two cases AKD in SLE. First, 21 years old female with decreased glomerular filtration rate (GFR) 31,5 for 4 weeks and renal biopsy membranous nephropathy. Second, 22 years old female with decreased GFR 27,7 for 6 weeks with focal segmental glomerulosclerosis. Both of them were treated with intravenous methylprednisolone pulse therapy followed by oral methylprednisolone and hydroxychloroquine. Their symptoms improved, and renal functions recovered gradually.

Keywords: Acute Kidney Disease; Lupus Nephritis; Systemic Lupus Erythematosus; Membranous Nephropathy; Focal Segmental Glomerulosclerosis

Topic: Non-communicable diseases related to women