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61	Biology Education	ABS-95
Integrated Visible Thinking Routine Through STEAM and Empathy Projects Erna Maryati M.Pd, Istianah, S.Pd, Elsa Anggiya Nurinsani S.Pd SMPIT NF Bogor Abstract This paper is based on the results of first and second year of two-year study in integrating Science, Technology, Engineering, Art, and Mathematics (STEAM) and empathy in social and natural science learning. The research focused on integrating visible thinking routine through STEAM and Empathy projects in Junior High School students of Nurul Fikri Boarding School Bogor. The visible thinking routine are steps that make complex thinking processes accessible to students through the use of Visual Thinking. The study was conducted in various contextual topics of social and natural science. A qualitative methodology was applied to explore the students^ learning experiences and understanding the research context. Data was collected through observation, interview, and reflective journal. The STEAM approach was integrated through modification of project-based learning model. The students had opportunities to develop their own projects by integrating material content and STEAM and empathy principles to their project. The results showed that students have developed their higher order thinking skills namely critical and creative thinking, problem-solving, collaboration and argumentation. They also learnt to develop skills of information, literacy and the self-direction. Keywords: Visible thinking routine, STEAM, Empathy, skills, literacy Share Link | Plain Format | Corresponding Author (Elsa Anggiya Nurinsani)

62	Biology Education	ABS-107
Medicinal Plants in Schoolyards as Learning Resources Ratna Dewi Wulaningsih, Mieke Miarsyah Biology Education Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta Abstract MTs. Al-Hidayah 2 Bogor in 2019 is a school with a newly built building, has land that requires reforestation. Greening is important for providing oxygen to the school environment, and some of these plants have medicinal properties. These medicinal plants include ginger, fragrant pandan, Rosella, green betel, and so on. The purpose of this research is to do reforestation by planting medicinal plants, for the maintenance of health and the preservation of the surrounding environment, as well as being a source of learning for students at school, knowing student attitudes, and increasing student knowledge about medicinal plants. Planting is done by students by digging the soil and inserting the available plants into it, then covering it with ready-to-plant soil media. Plant maintenance is carried out by clearing the land of weeds, to prevent competition for plant nutrients, in addition to cleanliness and beauty. The remains of plants and grass are dried and then buried deep into the soil because it can increase soil fertility. The rest of this plant can also be processed to be used as organic fertilizer or compost. Provision of water by means of continuous watering is very important, especially for young and newly growing plants, for further this watering activity can be adjusted to the environmental conditions of the yard, whether dry or wet (humid). Damaged plants are replaced with better ones. Next, students filled out attitude questionnaires, and worked on pre-test and post test questions about knowledge of medicinal plants. The results showed that students had good attitudes, and there was an increase in students knowledge of medicinal plants, and plants planted by students grew well, which were useful for the maintenance of the surrounding ecosystem, and were a source of learning for students at school. Keywords: Planting, medicinal plants, learning resources Share Link | Plain Format | Corresponding Author (Ratna Dewi Wulaningsih)

63	Biology Education	ABS-108
The Relationship between Curiosity and Reading Comprehension Ability with Science Literacy in High School Students Ratna Dewi Wulaningsih, Dhia Rahid, Mieke Miarsyah Biology Education Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta Abstract Science plays an important role in the life of modern society in an effort to meet their needs. Scientific literacy is an ability that must be possessed in order to be able to think logically, think critically and creatively, be able to solve problems, master technology and be adaptive to changes and developments of the times. Curiosity about science will support one^s scientific literacy. Knowledge can be obtained through various ways, one of which is through the reading process. Good reading skills will support someone to understand science content. This study aims to determine the relationship between curiosity and reading comprehension ability with high school student scientific literacy. This research was conducted at SMA Negeri 98 Jakarta in semester 1 of the 2019/2020 academic year, this research method uses the correlational method. Data were analyzed by means of multiple correlation significance test. The results showed that there was a significant positive relationship between curiosity and scientific literacy, there was a significant positive relationship between the ability to read comprehension and scientific literacy, there was a significant positive relationship between curiosity and the ability to read comprehension and scientific literacy. This shows that the higher the curiosity and reading comprehension ability of students, the higher the students scientific literacy ability. Keywords: curiosity, reading comprehension ability, scientific literacy Share Link | Plain Format | Corresponding Author (Ratna Dewi Wulaningsih)

64	Biology Education	ABS-110
Development of Digital Educational Comics Waste Materials as Learning Supplements to Improve Learning Outcomes of Class X Vocational High School Students. Ni Luh Chandrika Dewi Sarwithini (a*), Mieke Miarsyah (b), Ade Suryanda (b) State University of Jakarta Abstract 21st century learning must align technology and learning activities. the learning process must be designed more creatively in order to achieve the learning objectives. Characteristics of 21st century students have a tendency to learn more outside the schoolbook format, such as learning supplements. This research aims to develop a digital educational comic learning supplement for Vocational High Schools [SMK]. The subjects of this study were students of class X SMK Negeri 46 Jakarta. This type of research is development research which is adopted from the Borg and Gall development model. The instruments used in this research include media validation sheets, teacher interviews, response questionnaires and learning outcomes tests. Based on media trials in the field, the following results were obtained: [1] The media developed was very feasible with an average media validation questionnaire by experts of 91.5 percent. [2]The results of the effectiveness test of the digital educational comic learning supplement developed on waste material can improve student learning outcomes. These results show that the digital education comic learning supplement developed is very feasible to be used in supporting learning activities in the classroom. Keywords: Digital educational comics, learning outcomes, research development, learning supplements. Share Link | Plain Format | Corresponding Author (NI LUH CHANDRIKA DEWI SARWITHINI)

65	Biology Education	ABS-141
Sign language enrichment with Biology content: an effort to facilitate conceptual understanding for deaf student Yulilina Retno Dewahrani, Ade Suryanda Universitas Negeri Jakarta Abstract In the learning process, deaf students have difficulty actively involved in the biology learning process. That is due to the lack of biological terminology sign vocabulary available in the SIBI dictionary, so the material cannot be conveyed properly by the teacher and cannot be properly received by students with hearing disabilities. As a result, learning mastery according to the basic competencies in the 2013 Curriculum is less than optimal. During the pandemic, these difficulties are exacerbated because learning is carried out online. Barriers arise when communicating biological terminology effectively. In the SIBI dictionaries, there are 78 biology terminology sign vocabularies. The number is not commensurate with the biology terms they have to master to understand the concept of biology. Biological sign vocabulary enrichment aims to facilitate understanding of biology concepts for students with hearing disabilities. Some of biology sign vocabularies cues made in the form of pictures and videos. The resulting product is validated by media experts, sign language experts, and special education teachers and tested on deaf students. Keywords: biology concept, deaf student, SIBI, sign language Share Link | Plain Format | Corresponding Author (Yulilina Retno Dewahrani)

66	Biology Education	ABS-181
Developing and implementing em-respiropedia based on the RQA learning model: How does it impact biological literacy? Rizhal Hendi Ristanto, Ibrahim Fatahillah, Rusdi, Diana Vivanti Sigit Biology Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta Abstract Biological literacy can be learned from high language writing such as school and college Biology textbooks. This study aims to develop learning media in the form of RQA-based m-respiropedia and improve Biological literacy in the human respiratory system material. RQA-based M-respiropedia is created using the Research & Development (R&D) method, which contains content that supports bird conservation knowledge. This electronic module is done through the stages of analysis, design, development, implementation, and evaluation (ADDIE). This media is feasible through due diligence by media experts, material and language experts, teachers, and students. This research was conducted at SMAN 102 Jakarta. Then, the effectiveness test results were calculated using the Kolmogorov-Smirnov normality test, Fisher^s homogeneity test, and paired t-test. The results obtained are RQA-based M-respiropedia to influence and enhance Biological literacy in students Keywords: ADDIE model, Biological literacy, electronic module, RQA. Share Link | Plain Format | Corresponding Author (Rizhal Hendi Ristanto)

67	Biology Education	ABS-185
THINK TALK WRITE ALONG WITH MIND MAPPING: IMPROVING CREATIVE THINKING SKILLS ON ENVIRONMENTAL CHANGE Ericka Darmawan, Rizhal Hendi Ristanto, Diana Vivanti Sigit, Dikny Asti Khaerunisa, Ika Sukmawati Universitas Tidar Universitas Negeri Jakarta Abstract Creative thinking skills contribute to generating various kinds of ideas to create solutions. Students must have creative thinking skills to face the challenges of the 21st century. This study aims to examine the effect of the Think Talk Write (TTW) learning model along with Mind Mapping on creative thinking skills in X grade high school students in the Environmental Change Chapter. The research was carried out at SMA Negeri 53 Jakarta in the even semester of the 2018/2019 Academic Year. This study applies a quasi-experimental design using a pretest-posttest control group design. There were 66 students involved in this study which were then divided into 2 classes, namely the experimental group (n = 33) and the control group (n = 33). The students were taken randomly from each class using simple random sampling technique and the sampling was carried out using the Slovin formula. The data were collected using test instrument of creative thinking skills in the form of 12 items description questions and observation sheets of learning implementation as well as student response questionnaires. The data of both classes were analyzed using t-test. After giving treatment to the experimental group, the resultant p-value was 0.001 < 0.05. It shows that there is a significant effect between the experimental class and the control class. Thus, it is concluded that there is an influence of the Think Talk Write learning model along with Mind Mapping on students^ creative thinking skills in the environmental change chapter. Keywords: higher order thinking skills, 21st century skill Share Link | Plain Format | Corresponding Author (Ericka Darmawan)

68	Chemistry	ABS-18
In Silico Molecular Docking Study of Isolated Compounds from Clusiaceae Family as SARS-COV2 Main Protease Inhibitor Neneng Siti Silfi Ambarwati (a), Islamudin Ahmad (b*) a) Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, Jl. Rawamangun Muka, East Jakarta 13220, Indonesia b) Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mulawarman University, Jl. Kuaro Gn. Kelua, Samarinda 75119, East Kalimantan, Indonesia Abstract Clusiaceae Family are plants that are commonly found in Indonesia, 33 isolates of compounds from these plants have been obtained. These compounds can be developed and utilized to deal with the COVID-19 pandemic with an in silico molecular docking study approach. Therefore, this study aims to predict the activity of SARS-CoV-2 main protease inhibitor from isolated compounds from plant compounds Clusiaceae species by in silico molecular docking study. Molecular docking was performed using autodocktools on the macromolecule SARS-CoV-2 main protease (PDB 6LU7, resolution 2.16 Angstrom). The docking simulation was performed using Lamarckian parameters including the mutation rate of 0.02, elitisim of 1, the population size of 150, the crossover rate of 0.80 , and 2500000 energy evaluations. The grid box used for the 4ym9 receptor consists of 36 x 62 x 40 centered on the active site X = -9,732- Y= 11.403- Z= 68,483 (XYZ-coordinates). The results showed that based on the binding energy value, there were only 4 compounds that had a lower binding energy than the native ligand, namely amentoflavone compounds (-11.53 kcal/mol), fukugiside (-10.91 kcal/mol), ananixanthone (-10, 38 kcal/mol) and canophyllol (-9.88 kcal/mol). Meanwhile, based on conformational interactions with the active site of the receptor, only amentoflavone and ananixanthone compounds have direct interactions with the active site of the receptor on residues of His 41 and Cys 145. Therefore, it can be concluded that amentoflavone and ananixanthone compounds have very good potential for further development as major protease inhibitors of SARS-CoV-2. Keywords: Amentoflavone- Clusiaceae- SARS-COV2- in silico- molecular docking Share Link | Plain Format | Corresponding Author (Neneng Siti Silfi Ambarwati)

69	Chemistry	ABS-40
Electrodeposition of Platinum Nanoparticles from Different Supporting Electrolyte Concentration for Ethanol Electrooxidation Application Amelia Sabella, Annisa Auliya, Setia Budi and An^amt Mohamed Noor Universitas Negeri Jakarta, The Center for Science Innovation, Universiti Malaysia Kelantan Abstract Platinum nanoparticles were successfully synthesized on fluorine doped tin oxide using the square-wave pulse deposition technique at different concentrations of supporting electrolyte. At 0.5 M H2SO4 supporting electrolyte, the nanoparticles form spherical particles surrounded by rough surface. As the concentration of the supporting electrolyte increases, the rough surface grows into fine spines which become thicker and clearer. Ethanol electrooxidation test using cyclic voltammetry showed that Pt0.5M has the highest anodic current compared to other catalysts, which was 3.153 mA/cm2. The high catalytic activity is supported by the low charge transfer resistance value of Pt0.5M in electrochemical impedance spectroscopy measurements. These results indicate that the high catalytic activity of the sample is due to its large number of particles and its shape which has many active sites, so that it can activate reactions in the system. Keywords: electrodeposition, ethanol electrooxidation, platinum nanoparticles, supporting electrolyte Share Link | Plain Format | Corresponding Author (Setia Budi)

70	Chemistry	ABS-50
Antioxidant Activities of Biflavonoids from Indonesia Araucaria columnaris Leaves Kurniawanti1, Dhea Demitri Agusta1, Purwantiningsih Sugita1*, Irma Herawati Suparto1, Hanhan Dianhar2, Dyah Utami Cahyaning Rahayu3 1Departement of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia 2Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Jakarta, Jakarta 13220, Indonesia 3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16424, Indonesia Abstract One of the biological activity of biflavonoids are reported to have potential as antioxidants. Biflavonoids could be found in various higher plants and one from Araucaria genus is Araucaria columnaris plant. There are eleven biflavonoids have been reported from the leaves of A. columnaris which are grown in Hawaii and India. This species is also grown in the Bogor Botanical Gardens, Indonesia, however, there are no recent studies have been reported on secondary metabolites, especially biflavonoids, from Indonesian A. columnaris. Therefore, this research aimed to isolate biflavonoids from leaves of Indonesian A. columnaris using extraction methods and various chromatographic techniques, such as gravity column chromatography with silica gel and Sephadex LH-20 as a stationary phase, radial chromatography and preparative thin-layer chromatography. Furthermore, the extracts and secondary metabolites isolated were also examined their activity as antioxidants using a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Three biflavonoid compounds have been successfully obtained from the acetone extract of A. columnaris leaves, and one of them was successfully elucidated according to their spectroscopic data, including IR, UV-Vis, NMR (1H, 13C, HSQC, and HMBC), and MS spectra as 4^,4^^,7,7^^ -tetra-O-methylcupressuflavone (1). The other two biflavonoids are not yet finished analysis. The preliminary antioxidant assay of acetone extract of the leaves A. columnaris showed moderate activity with IC50 of 69.2 ppm, whereas compound 1 showed weak activity with IC50 >100 ppm. Keywords: Araucaria columnaris, Biflavonoids, Antioxidant, DPPH. Share Link | Plain Format | Corresponding Author (Kurniawanti kurniawanti)

71	Chemistry	ABS-53
Optimization of Silver Nanoparticle Synthesis Using Fingerroot (Curcuma rotunda L.) Rhizome Extract as a Bioreduction agent Wisnu Widikdo, Purwantiningsih Sugita*, Mohammad Khotib Departement of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, Indonesia Abstract Curcuma rhizomes are reported to have high total phenolic content. Phenol compounds can act as a bio reductor in the reduction of metal into metal nanoparticles. Five Curcuma rhizome extract were chosen for bio reductor, such as temu putih (Curcuma zedoaria), temu hitam (Curcuma aeruginosa), temu kunci (Curcuma rotunda L.), temu giring (Curcuma heyneana), and temu mangga (Curcuma amada). The silver nanoparticles (AgNPs) were synthesized by mixing 0.2 g of rhizome extract with AgNO3 then, the solution irradiated with a 366 nm UV lamp at a particular time and pH. The synthesis of AgNPs was confirmed by the colour change of the solution from yellow to dark brown and by UV-Visible spectroscopy. Based on UV-Vis spectra, the highest silver nanoparticle yield is obtained by using temu kunci extract as a bio reduction agent. Their optimum conditions were analyzed using response surface methodology (RSM) based Box-Behnken design (BBD) using Minitab 17. The key factors are pH, irradiation time, and mass ratio of AgNO3. Statistics results revealed that 0.13 g of silver nitrate with 178 minutes of irradiation time at pH 11.5 were the optimum values for AgNPs biosynthesis. The characterization of AgNPs is not yet finished. Keywords: Box-Behken Design, Curcuma, C. rotunda, silver nanoparticles. Share Link | Plain Format | Corresponding Author (Wisnu Widikdo)

72	Chemistry	ABS-69
Microwave Assisted Synthesis of Coumarin 3-carboxylate Through Knoevenagel Condensation with Aluminum Chloride Catalyst Syifa Aulia Mumpuni, Hanhan Dianhar, Fera Kurniadewi, Zulhipri Chemistry, Universitas Negeri Jakarta Jl. Rawamangun Muka Raya No. 11, Jakarta Timur 13220, Indonesia Abstract Coumarin is a therapeutic agent, found as a natural secondary metabolite in plants, bacteria, fungi, essential oil, and can be chemically synthesized. One of the coumarin derivatives biology activities is as an antimicrobial. This study aims to do coumarin synthesis with microwave assisted synthesis method via Knoevenagel condensation. Which, coumarin synthesized from stirring 20 mmol of 2-hydroxy-benzaldehyde and 24 mmol of diethyl malonate without solvent (solvent-free) and then adding aluminum chloride catalyst, put it in the microwave for 10 minutes with an interval of 10 second. This synthesis monitored with Thin Layer Chromatography (TLC) with n-hexane and ethyl acetate (8:2) as the eluent. Purification is done by recrystallization. Synthesis product then tested for its melting point and also characterization with UV-Vis spectroscopy. Keywords: coumarin, synthesis, Knoevenagel condensation, microwave assisted, solvent-free Share Link | Plain Format | Corresponding Author (Syifa Aulia Mumpuni)

73	Chemistry	ABS-70
Synthesis of Chalcone Derivatives from Vanillin and Acetophenone Nabila Seflini, Hanhan Dianhar Universitas Negeri Jakarta Abstract A series of chalcones from vanillin and acetophenone were synthesized by the Claisen-Schmidt reaction using a microwave with a KOH base catalyst. The mixture was irradiated by microwave at 180 watts for 5 minutes. After the reaction was complete, the mixture was added with cold distilled water and HCl, then left for 24 hours in the refrigerator after which it was recrystallized. Pure chalcone was obtained with a yield of 97.64 percent and a melting point of 84 degrees Celcius. The synthesized chalcones were characterized by UV, NMR, and MS Spectrophotometry. Keywords: Chalcone- Vanillin- Acetophenone- Claisen-Schmidt- Microwave Share Link | Plain Format | Corresponding Author (Nabila Seflini)

74	Chemistry	ABS-71
SYNTHESIS OF A CHALCONE DERIVATIVE FROM VANILLIN USING MICROWAVE IRRADIATION METHOD Pandu Rizki Triananda, Hanhan Dianhar, Fera Kurniadewi, Zulhipri Chemistry, Universitas Negeri Jakarta Jl. Rawamangun Muka Raya No. 11, Jakarta Timur 13220, Indonesia Abstract Chalcone compound is one of derivatives of flavonoid and reported to have many bioactivity such as antibacterial, anticancer, antioxidant, and anti-inflammatory. The broad use of chalcone continuously supports research on chalcone synthesis and its bioactivity. Microwave-assisted organic synthesis is used due to its capability on making less reaction time, easy work up and cleaner products. Synthesis of a chalcone derivative from vanillin and 4-hydroxyacetophenone has been carried out by means of a Claisen-Schmidt condensation to obtain 3-(4-hydroxy-3-methoxyphenyl)-1-(4^-hydroxyphenyl)-2-propen-1-on with a base catalyst using the microwave irradiation method. The product was appeared in a yellow solid with a yield of 80,65% and a melting point of 112 degree celcius. The UV spectrum of the synthesized chalcone showed a maximum absorption at a length of 358 nm and 270 nm which falls within the specific regional range for chalcone. Keywords: chalcone, Claisen-Schmidt condensation, microwave irradiation, synthesis, vanillin Share Link | Plain Format | Corresponding Author (Pandu Rizki Triananda)

75	Chemistry	ABS-73
Synthesis 3-Acetyl Coumarin via Knoevenagel Condensation Under Microwave Irradiation Reyhan Syifa, Hanhan Dianhar, Fera Kurniadewi, Zulhipri Chemistry Study Program, Faculty of Mathematics and Natural Sciences Universitas Negeri Jakarta, Jalan Rawamangun Muka, Kel. Rawamangun East Jakarta 13220, Indonesia. Abstract Coumarin is a therapeutic agent that can be found naturally as secondary metabolite in plants, bacteria, fungi, essential oils and can be chemically synthesized. The Knoevenagel reaction is one of the most useful C=C bond formation processes involving the condesation between benzaldehyde and activated methylenes in the presence of an amine. The Knoevenagel reaction is commonly used to synthesize coumarin. This study aimed to synthesize 3-acetyl coumarin and determine the structure analysis. In this research, 3-acetylcoumarin was obtained from 2-hydroxy benzaldehydes and ethyl acetoacetate at molar ratio 1.2:1 in the presence of diethylamine as a catalyst via Knoevenagel reaction under microwave irradiation for 60 s. The purity of obtained 3-acetyl coumarin was investigated by Thin Layer Chromatography and melting point test then characterized by UV-vis and NMR spectroscopy for further structure analysis. It was found that the melting point of the obtained 3-acetyl coumarin around 120-122oC. In conclusion, this method can be used to synthesize 3-acetyl coumarin in shorter reaction time than conventional method. Keywords: 2-hydroxy benzaldehyde, coumarin, knoevenagel condesation, microwave irradiation, synthesis Share Link | Plain Format | Corresponding Author (Reyhan Syifa)

76	Chemistry	ABS-96
grxB gene as a potential target for the development of a Cronobacter sakazakii detection method in infant formula milk using PCR Muktiningsih Nurjayadi (a*), Dandy Akbar Juliansyah (a), Jefferson Lynford Declan (a), Gladys Indira Putri (a), Ismaya Krisdawati (a), Maharanianska Azzahra (a), Irvan Maulana (a), Adinda Myra Amalia Putri (a), Irma Ratna Kartika (a), Fera Kurniadewi (a), Dalia Sukmawati (b), Sri Rahayu (b), Vira Saamia (c), Dwi Anna Oktaviani Saputro (c), I Made Wiranatha (c), H. E. Enshay (d)(e)(f) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia *muktiningsih[at]unj.ac.id b) Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 9th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia c) Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Ciapmbuan Babakan Madang, Bogor, 1681, Indonesia d) Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. e) School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. f) City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract Cronobacter sakazakii is a pathogen that causes necrotizing enterocolitis, sepsis, and meningitis in infants or neonates with reported case-fatality rates varying from 40 to 80 percent. Therefore, it is necessary to develop fast and accurate detection of C. sakazakii. This study aims to get the primer pairs and optimal annealing temperature for the Polymerase Chain Reaction (PCR) method to detect C. sakazakii. The glutaredoxin B (grxB) gene was found to be suitable for the detection of Cronobacter sakazaki, and a primer pair based on the grxB gene sequence was designed and synthesized. The genomic DNA of Cronobacter sakazakii strain ATCC 29544 was isolated and then used as a template for PCR assay. Optimization of running PCR conditions was carried out by varying the annealing temperature at the temperature range between 53-62 degree Celsius and the template DNA concentration of C. sakazakii is 53 ng/micro Liter with a purity (A260/280) of 1,853. The results showed that the primer grxB gave optimal results at the annealing temperature range between 57-61 degree Celsius. In addition, the results also showed that the grxB primer pair could amplify the grxB C. sakazakii fragment to produce an amplicon with a size of 151 base pairs (bp) and only single band was formed. Furthermore, the results of the primer design and the optimum temperature obtained will be used for the development of a sensitive and specific rapid detection method of C. sakazakii in food samples using real time PCR. Keywords: Cronobacter sakazakii, grxB Gene, Polymerase Chain Reaction Share Link | Plain Format | Corresponding Author (Muktiningsih Nurjayadi)

77	Chemistry	ABS-97
Optimization, Scaling-up and establishment of herbal processing technology for the production of bioactive extracts from selected Malaysia medicinal plant Zarani Mat Taher1*, Nik Nur Naqiah Mustofar1, Rashidah Ahmed1, Nur Amirah Azelan1, Mohd. Azrie Awang1, Ida Madiha Yusoff1, Chua Lee Suan1, Azila Abdul Aziz 1,2 1Institute of Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Johor Bahru, Malaysia. 2Malaysia Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur Malaysia Abstract The value and quality of natural products in various applications has sparked interest in medicinal plant processing characteristics especially in healthcare. The processing parameters to produce optimized water extracts from Piper Betle L. (sireh), Piper Sarmentosum (kaduk), Gynura Procumbens (sambung nyawa ) and Melastoma malabathrium L. (senduduk) with consistent chemical markers and bioactivity, and the scale up of the processes from lab scale to pilot scale had been investigated. At optimized processing conditions of each plant, the yield of Piper betle L crude extract was 25.53% and the content of hydroxychavicol in crude was 6.56%- the.yield of Piper sarmentosum crude extract was 18.96% and the content of beta sitosterol in crude was 0.785%- the yield of Gynura Procumbens crude extract was 15.35% and the content of chlorogenic acid in crude was 6.11%- and the yield of Melastoma malabthricum leaves crude extract was 20.036 % and the content of quercitrin in crude was 3.071%. Total phenolic content evaluation was undertaken and the result shows that all investigated plants have high antioxidant activity. Evaluations of antidiabetic activity were carried out and Melastoma malabathrium showed the highest inhibition followed by Gyanura procumbens, Piper betle and Piper sarmentosum. All water extracts of the plants showed no anti-microbial activity when tested on Bacillus subtilis, Staphylococcus aures , Escherichia coli and Candida albicans. Scaling up study from laboratory scale to pilot scale was conducted successfully using dimensional analysis. The resuls of this scaling up study show that water extracts of Piper Betle L. (sireh), Piper Sarmentosum (kaduk), Gynura Procumbens (sambung nyawa ) and Melastoma malabathrium L. (senduduk) with consistent chemical markers and bioactivity had been obtained. Therefore, the potential of these medicinal plant is promising for various applications such as food , cosmetic and pharmaceutical. Keywords: medicinal plant, optimization, scaling-up, chemical markers, bioactivity Share Link | Plain Format | Corresponding Author (ZARANI MAT TAHER)

78	Chemistry	ABS-98
The Potential of inlA Gene as a Target Detection for Listeria monocytogenes in Vegetables Sample using Polymerase Chain Reaction Method Muktiningsih Nurjayadi (a*), Jefferson Lynford Declan (a), Gladys Indira Putri (a), Ismaya Krisdawati (a), Dandy Akbar Juliansyah (a), Maharanianska Azzahra (a), Irvan Maulana (a), Rosita Gio Anggraeni (a), Irma Ratna Kartika (a), Fera Kurniadewi (a), Dalia Sukmawati (b), Sri Rahayu (b), Vira Saamia (c), Dwi Anna Oktaviani Saputro (c), I Made Wiranatha (c), H. E. Enshay (d)(e)(f) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia *muktiningsih[at]unj.ac.id b) Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 9th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia c) Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Cipambuan Babakan Madang, Bogor, 1681, Indonesia d) Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. e) School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. f) City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract Listeria monocytogenes is a bacteria that causes food poisoning and is found in various types of food. It can infect humans with a mortality rate up to 30 percent. The aim of this study is to determine the potential of internalin A (inlA) gene with Gradient Polymerase Chain Reaction (PCR) as a basis for developing a detection method for Listeria monocytogenes in vegetables using Real-Time PCR. In this study a round white colony was obtained on the Brain Heart Infusion (BHI) agar. In liquid media, the OD600 value is 1.418, which indicates the growth of bacteria. The DNA used as a template had a concentration of 72 ng/micro Liter with A260/280 purity around 1.802. Variation of annealing temperature in Gradient PCR between 53-62 degree Celsius based on melting temperature of the primer. The primer successfully amplifies the inlA gene fragment with an amplicon size 161 base pair. In addition, the optimum annealing temperature for these primers was 60 degree Celsius based on the brightest band and a single band formed in electrophoresis. In the future primers and optimum annealing temperature can be used to develop detection kit for Listeria monocytogenes bacteria in vegetables using Real-Time PCR method. Keywords: Detection, Foodborne Disease, inlA gene, Listeria monocytogenes, Polymerase Chain Reaction Share Link | Plain Format | Corresponding Author (Muktiningsih Nurjayadi)

79	Chemistry	ABS-99
The Potential of The ToxR Gene As A Detection Tool for Vibrio parahaemolyticus in Seafood Muktiningsih Nurjayadi (a*), Ismaya Krisdawati (a), Gladys Indira Putri (a), Jefferson Lynford Declan (a), Dandy Akbar Juliansyah (a), Maharanianska Azzahra (a), Irvan Maulana (a), Atikah Nur Rahmawati (a), Irma Ratna Kartika (a), Fera Kurniadewi (a), Dalia Sukmawati (b), Sri Rahayu (b), Vira Saamia (c), Dwi Anna Oktaviani Saputro (c), I Made Wiranatha (c), H. E. Enshay (d)(e)(f) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia *muktiningsih[at]unj.ac.id b) Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 9th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia c) Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Ciapmbuan Babakan Madang, Bogor, 1681, Indonesia d) Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. e) School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. f) City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract Vibrio parahaemolyticus must be detected quickly and precisely. The purpose of this study is to use the Gradient Polymerase Chain Reaction (PCR) method to evaluate the primer that can produce an amplicon at the ideal temperature for the Vibrio parahaemolyticus toxR gene. The toxR primer pair could amplify Vibrio parahaemolyticus toxR fragments to form an amplicon with size 171 base pairs, according to the in silico analysis conducted for the primer design. Gradient PCR was used to assess the primer^s suitability for the design outcome and determine the ideal temperature to generate amplicons of the appropriate size with the temperature ranges from 53 to 62 degree Celsius. The purity (A260/280) of the Vibrio parahaemolyticus isolate used as a template is 1.92 and its concentration is 51 ng/ micro liter. The study^s findings kindly reveal that annealing temperatures of 60 degree Celsius produce the best outcomes for the toxR primer which results in the formation of a clear DNA band with a thickness band intensity and a size of 171 base pairs. Additionally, the primers and ideal temperatures discovered were utilized for the Real Time PCR stage in the creation of sensitive, targeted, and quicker tools for the detection of Vibrio parahaemolyticus in seafood. Keywords: Foodborne Disease, Polymerase Chain Reaction, Seafood, toxR gene, Vibrio parahaemolyticus Share Link | Plain Format | Corresponding Author (Muktiningsih Nurjayadi)

80	Chemistry	ABS-100
Optimization fnbA gene target for potential detection Staphylococcus aureus as foodborne pathogen bacteria using Polymerase Chain Reaction Method Muktiningsih Nurjayadi (a*), Maharanianska Azzahra (a), Irvan Maulana (a), Ratna Nur Kusumawati (a), Nabila Alya Pramudiyasih (a), Jefferson Lynford Declan (a), Gladys Indira Putri (a), Ismaya Krisdawati (a), Dandy Akbar Juliansyah (a), Ayu Berkahingrum (a), Irma Ratna Kartika (a), Fera Kurniadewi (a), Dalia Sukmawati (b), Sri Rahayu (b), Vira Saamia (c), Dwi Anna Oktaviani Saputro (c), I Made Wiranatha (c), H. E. Enshay (d)(e)(f) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia *muktiningsih[at]unj.ac.id b) Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 9th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia c) Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Ciapmbuan Babakan Madang, Bogor, 1681, Indonesia d) Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. e) School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. f) City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract Staphylococcus aureus can be found in a wide range of areas and emerge as one of pathogenic bacteria that cause foodborne infection. Hence, the optimization for S. aureus detection itself needs to be developed, to produce more accurate results. This study aims to determine the optimal annealing temperature condition and the potential of fnbA primers target gene in the development of S. aureus detection using Polymerase Chain Reaction method. Primer pairs fnbA design was firstly synthesized and followed by the cultural growth process of S. aureus bacteria in MSA agar, resulting in producing yellow colonies. DNA isolate with concentration of 26 ng/ micro Liter and purity 1,8 of S. aureus ATCC 25923 was used as a PCR template. The optimization stage is carried out by varying the temperature at a range of 57-61 degree Celsius resulting in the appearance of annealing bands on agar when exposed to UV light. The results showed that the primer successfully amplified fnbA S. aureus gene with a single band showed the brightnest at temperature 60 degree Celsius and produced an amplicon 187 bp size as targeted. Thus, the optimal conditions that have been obtained can be used for the next stage of detection in food using Real-time PCR. Keywords: fnbA gene, Foodborne Disease, Polymerase Chain Reaction, Staphylococcus aureus Share Link | Plain Format | Corresponding Author (Muktiningsih Nurjayadi)

81	Chemistry	ABS-101
Optimal Annealing Temperature of Yersinia enterocolitica ymoA gene primers using the Polymerase Chain Reaction Method Muktiningsih Nurjayadi (a*), Gladys Indira Putri (a), Jefferson Lynford Declan (a), Ismaya Krisdawati (a), Dandy Akbar Juliansyah (a), Maharanianska Azzahra (a), Irvan Maulana (a), Niken K. Liman (a), Tiara Fahriza (a), Irma Ratna Kartika (a), Fera Kurniadewi (a), Dalia Sukmawati (b), Sri Rahayu (b), Vira Saamia (c), Dwi Anna Oktaviani Saputro (c), I Made Wiranatha (c), H. E. Enshay (d)(e)(f) a) Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 6th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia *muktiningsih[at]unj.ac.id b) Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Jakarta, Gedung KH. Hasjim Asj^ari, 9th Floor, Jl. Rawamangun Muka, Jakarta Timur, 13220, Indonesia c) Center Forensic Laboratory of the Criminal Investigation, Police of the Republic of Indonesia, Ciapmbuan Babakan Madang, Bogor, 1681, Indonesia d) Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. e) School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Malaysia. f) City of Scientific Research and Technology Applications, New Burg Al Arab, Alexandria, Egypt. Abstract The case of foodborne diseases has now become a serious global problem. Foodborne diseases occur due to contamination of pathogenic bacteria. One of the pathogenic bacteria that causes foodborne diseases is Yersinia enterocolitica. The aim of this research was to determine the annealing temperature of Yersinia enterocolitica ymoA gene primers using the PCR method to ensure that the primers can amplify ymoA gene fragments in Yersinia enterocolitica. In this research, the concentration of DNA as a template used was 70.5 ng/ micro Liter with a purity of A260/280 was 1.88. Optimization of the annealing temperature of Yersinia enterocolitica ymoA gene primers using the Gradient PCR in range of temperature between 57-61 degree Celsius based on the melting temperature value of the ymoA primers. The results of the primers design of the ymoA gene were confirmed to amplify the DNA fragment of Yersinia enterocolitica with an amplicon length of 185 bp. Based on the results, the temperature of 60 degree Celsius was chosen as the optimum primer annealing temperature for the ymoA gene in Yersinia enterocolitica, because only a brightness band produced on electrophoresis. This result can be continued with primers testing of the ymoA gene on meat samples using the Real-Time PCR method. Keywords: Foodborne diseases, Polymerase Chain Reaction, Yersinia enterocolitica, ymoA gene. Share Link | Plain Format | Corresponding Author (Muktiningsih Nurjayadi)

82	Chemistry	ABS-120
ANALYSIS OF PHOSPHORUS USING AMMONIUM MOLIBDATE WITH THIOUREA AND HIDRAZIN SULPHATE AS REDUCTORS BY USING UV-Vis SPECTROPHOTOMETRY METHOD Yussi Pratiwi (a), Zulhipri (b), Baiq Amelia Riyandari (c), Ayu Winani (d), Adelia Nisrina (e) (a)(b)(d)(e) Chemistry Study Progam, Faculty of Mathematics and Natural Science Universitas Negeri Jakarta, Indonesia (c) Department of Chemistry Education, Faculty of Education and Teacher Training Universitas Islam Negeri Mataram, Indonesia Abstract Analysis of phosphorus using UV-Vis Spectrophotometry method has been studied. This research aimed to get the optimum conditions for analysis of phosphorus, obtain information about the best reductor and apply this method for phosphorus analysis in vegetables which fulfills the parameters of method validation. This research was started by determining the optimum phosphorus analysis conditions, forming a yellow complex compound. This compound was unstable, so it needed to be reduced using thiourea and hydrazin sulphate to produce a stable blue complex. Furthermore, the phosphorus analysis was validated based on the method validation parameters. Molybdenum blue reaction produced a heterophosphomolybdate complex compound with a maximum wavelength of 689 nm. Based on the reduction of phosphomolybdate reaction, the linearity (R2) of thiourea was 0.9960, while hydrazine linearity was 0.9954. The molar absorptivity was 6.94 x 105 L mol-1 cm-1 and 8.6317 x 104 L mol-1 cm-1 for thiourea and hydrazin sulphate. Limit detection values of thiourea and hydrazin sulphate were 7.2 x 10-3 mg L-1 and 4.83 x 10-4 mg L-1, respectively. The percentage of RSD in each sample ranged from 1.08 to 1.40%. Moreover, each samples recovery percentage ranged from 98.03% to 107.30%. The phosphates contained in the vegetable samples did not pass the food quality standard, according to the Indonesian Nutritionist Association (PERSAGI). Keywords: phosporous, UV-Vis spectrophotometry, thiourea, hydrazine sulphate, method validation Share Link | Plain Format | Corresponding Author (Yussi Pratiwi)

83	Chemistry	ABS-121
Photopolymerization of Product Blending Methyl Methacrylate with Reactive Mesogen RM257 using the UV Curing Method A.Afrizal (a*), Setia Budi (a), Silfia Afriani (a), Annisa Ambarwati (a), Umar Kalmar Nizar (b) (a) Chemistry, Universitas Negeri Jakarta, East Jakarta 13220, Indonesia *afrizal[at]unj.ac.id (b) Chemistry, Universitas Negeri Padang, Air Tawar Padang, West Sumatra 25173, Indonesia Abstract Abstract. The purpose of this research is to identify the photopolymerization of product blending methyl methacrylate with reactive mesogen RM257 using the UV Curing method with time variations. UV radiation had a role in the formation of new polymer with the addition of Benzoyl Peroxide (BPO) initiator. Polymerization was carried out at a temperature of 125^{o}C in time variations of 5 minutes, 10 minutes, 15 minutes, and 20 minutes. Then the sample were characterized using FTIR and SEM. The FTIR spectrum shows that thin film has the same pattern absorption in all the time variations. The absorption peak appears at 2700-2900 cm^{-1} indicating of -CH_{3} bonds, 1660-1820 cm^{-1} indicating of C=O bonds, and 1000-1300 cm^{-1} indicating of C-O bonds. The SEM characterization was carried out at 1000x, 5000x, 10000x and 15000x magnifications. Samples with a time variation of 15 minutes had the best uniformity of morphological shape and visible molecular shape of rods in all samples which is a characteristic of reactive mesogen. XRD characterization was carried out at an angle range of 2\theta 10^{o}-90^{o}, there were sharp peaks with moderate intensity at 2\theta 13.90^{o} and 16.83^{o}, high intensity appeared at 2\theta 44.66^{o}, this indicates that the thin film is semicrystalline. Keywords: Liquid Crystal, Methyl Methacrylate, Reactive Mesogen RM257, UV Curing, Polymer Share Link | Plain Format | Corresponding Author (Silfia Afriani)

84	Chemistry	ABS-122
DETERMINATION OF PHOSPHORUS THROUGH FORMATION OF PHOSPHOMOLYBDATE COMPLEX WITH SnCl2 AND THIOUREA AS REDUCTOR BY UV-Vis SPECTROPHOTOMETRY Yussi Pratiwi (a), Zulhipri (b), Elsa Vera Nanda (c), Aulia Natasya (d), Ayu Winani (e) Chemistry Study Progam, Fakulty of Mathematics and Natural Science Universitas Negeri Jakarta, Indonesia Abstract Analysis of phosphorus using UV-Vis Spectrophotometry method has been studied. This research aimed to get the optimum conditions for analysis of phosphorus, obtain information about the best reductor and apply this method for phosphorus analysis in vegetables which fulfills the parameters of method validation. This research was started by determining the optimum phosphorus analysis conditions, forming a yellow complex compound. This compound was unstable, so it needed to be reduced using SnCl2 and thiourea to produce a stable blue complex. Furthermore, the phosphorus analysis was validated based on the method validation parameters. Molybdenum blue reaction produced a heterophosphomolybdate complex compound with a maximum wavelength of 729 nm. Based on the reduction of phosphomolybdate reaction, the linearity (R2) of SnCl2 was 0.9963, while thiourea linearity was 0.9960. The molar absorptivity was 6.77 x 105 L mol-1 cm-1 and 6.94 x 104 L mol-1 cm-1 for SnCl2 and thiourea. Limit detection values of SnCl2 and thiourea were 4.37 x 10-4 mg L-1 and 7.2 x 10-3 mg L-1, respectively. The percentage of RSD in each sample ranged from 1.19 to 1.93%. Moreover, each sample^s recovery percentage ranged from 99.36% to 109.50%. The phosphates contained in the vegetable samples did not pass the food quality standard, according to the Indonesian Nutritionist Association (PERSAGI). Keywords: phosporous, UV-Vis spectrophotometry, SnCl2, thiourea, method validation Share Link | Plain Format | Corresponding Author (Yussi Pratiwi)

85	Chemistry	ABS-127
Simulation of Vitamin C Derivatives as Antioxidant Using Molecular Docking Irma Ratna Kartika1, Muktiningsih Nurjayadi1, Irwan Saputra1, Hanhan Dianhar1, Teni Ernawati2, Puspa Dewi N. Lotulung2, Mohamad Sadikin4, Sri Widia A. Jusman4 1Chemistry Undergraduate Program, FMIPA, UNJ, Jakarta 13220, Indonesia 2Biomedical Science Doctoral Program, FKUI, Jakarta 10440, Indonesia 2Medicinal Chemistry Research Group, National Research and Innovation Agency, Kawasan PUSPIPTEK Serpong Tangerang Selatan, Banten 15314, Indonesia 4Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, 10430, Indonesia Abstract Vitamin C (ascorbic acid) plays a role as an exogenous antioxidant to protect biomolecules against cellular redox-reactive species generation including ROS that are involved in the development of oxidative stress-related diseases. Therefore, some ascorbic acid studies have concentrated on its ROS scavenging activity. We designed a combination of vitamin C and octanoic acid as vitamin C derivatives to evaluate their antioxidant potential in silico study using molecular docking. Compound 1 demonstrated the receptor-ligand interaction in Lipoxygenase (LO) than Zileuton-ZIL with its lower binding free energy (&#916-G) and inhibition constant (Ki) value. Meanwhile, 6 exhibited lower Gibs energy (&#916-G) and inhibition constant (Ki) in NADPH oxidase (NO) receptor than Dextromethorphan-DEX. The results add to the evidence supporting antioxidant activities of 1 and 6 in two receptors (LO and NO, respectively) via ROS generation. Thus, further research is warranted into their efficiency in the reduction of oxidative stress for possible commercial antioxidants. Keywords: antioxidant potential, molecular docking, vitamin C Share Link | Plain Format | Corresponding Author (Irma Kartika)

86	Chemistry	ABS-144
Cyclomorusin and Cudraflavone C from The Wood of Nangkadak (Moraceae) and Their Antioxidant Activities Widha Rosa Kartika, Lita Amalia Ramadhanti, Dinda Oktaviani, Tika Rosiana, Muktiningsih, Hanhan Dianhar, Fera Kurniadewi*) Chemistry Study Program, Universitas Negeri Jakarta, Jalan Rawamangun Muka, Jakarta 13220, Indonesia Abstract Two flavone derivatives, Cyclomorusin (1) and Cudraflavone C (2) had been isolated from the ethyl acetate extract of the wood of Nangkadak. This species results from a cross between a female mini jackfruit (Artocarpus heterophyllus) and male broodstock from cempedak (Artocarpus integer). The chemical structure of these compounds was identified based on their spectroscopic data, including UV, IR, and NMR spectra. Compounds 1 and 2 were evaluated for their antioxidant activity by the DPPH method, showing their IC50 was 116.0 (weak) and > 200 (inactive) ppm, respectively Keywords: Artocarpus, cyclomorusin, cudraflavone C, antioxidant Share Link | Plain Format | Corresponding Author (Fera Kurniadewi)

87	Chemistry	ABS-145
Potential antioxidant Flavonoids from Ethyl Acetate Fraction of Artocarpus champeden stem Eva Handayani, Siti Rahmawati, Triska Nelanda, Sakiro Widya Silvani, Muktiningsih, Hanhan Dianhar, Fera Kurniadewi* Chemistry Study Program, Universitas Negeri Jakarta, Jalan Rawamangun Muka, Jakarta 13220, Indonesia Abstract This study aims to obtain and determine the secondary metabolite structure of ethyl acetate fraction of Artocarpus champeden stem and its antioxidant activity using the DPPH method. Ethyl acetate fraction was fractionated using several chromatographic techniques. Data analysis results such as UV-Vis and 1H-NMR showed that the isolated compounds were flavanone derivatives, i.e., Artocarpanone (1) artocarpin (2), and kudraflavone C (3). Antioxidant assay of these isolated compounds using the DPPH method showed that all isolated compounds had a potent antioxidant activity with IC50 values were 99.3, 45, and 17.724 ppm, respectively. Keywords: Artocarpus champeden, artocarpin, cyclomorusin, cudraflavone C, antioxidant Share Link | Plain Format | Corresponding Author (Fera Kurniadewi)

88	Chemistry	ABS-146
Model of River Environmental Management Based on Sustainable Community Social Capital Dwi Atmanto Cosmetology Education Study Program, Faculty of Engineering, Universitas Negeri Jakarta Abstract River is a source of water that flows from upstream to downstream. Many people live along the river. As a result, many people dump domestic or industrial waste into river bodies. However, there are also community groups who care about the river environment. The research location is the Ciliwung river. Social capital data such as togetherness, mutual trust, sharing, cooperation (Cooperation), resource mobilization, and the principle of reciprocity. The research method uses a survey of the people who live along the Ciliwung river and non-governmental organizations that care about the quality of the river^s environment. The data collected was processed descriptively and made a model using a dynamic system (Powersim). The results showed that the influence of social capital togetherness of the community on the quality of the river environment was 45.8%, the influence of the mutual trust factor was 43.5%, the influence of the sharing factor was 55.2%, the influence of the Cooperation (cooperation) factor was 56.8%. , the influence of the resource mobilization factor is 61.4% and the influence of the reciprocal factor is 43.9%. The system dynamics model is built with community social capital (citizens, NGOs, and entrepreneurs) and the role of the government where each model is 100% supported by community social capital, 100% government support, then the quality of the river environment (BOD and COD indicators) can be achieved in 18 years. While model 2 and model 3 with social capital of the community and the role of the government between 40%-70% the quality of the river environment can reach 40 years. Keywords: Community, River environmental management, System dynamics model, social capital, sustainable. Share Link | Plain Format | Corresponding Author (Dwi Atmanto)

89	Chemistry	ABS-147
Mangrove Leaf Extract Substitution Formulation in Making Hand Soap to Improve Environmental Health of Coastal Communities, Muara Gembong District, Bekasi Regency, West Java Dwi Atmanto Cosmetology Education Study Program, Faculty of Engineering, Universitas Negeri Jakarta Abstract Many mangrove plants develop in the coastal areas of Indonesia. Not all mangroves can grow on the coast of Indonesia. Mangrove leaves have good nutritional value for skin care and can be used to soften the skin, so it can be used as a humectant in hand soap. Hand soap is very much needed during the Covid-19 pandemic, to clean hands that are often used for activities such as touching the face, eyes and nose. Experimental research method with 4 formularies. The ingredients for hand soap are texapon, emal needle, NaCl, humectants, foam boosters, preservatives, antibacterials, perfumes, dyes and aquades. Testing the results using a panelist test and organoleptic test by 15 residents of Muara Gembong District, Bekasi Regency, West Java. The results showed that (a) the addition of NaCl slowly after mixing aquadest with 1% mangrove leaf extract was a score of 10, a score of 5% of mangrove leaf extract was 18, a score of 10% of mangrove leaf extract was 24, and a score of 15% of mangrove leaf extract. is 20. (b) the addition of NaCl salt before adding aquadest with 1% mangrove leaf extract is a score of 10, a score of 5% of mangrove leaf extract is 19, a score of 10% of mangrove leaf extract is 35, and a score of 15% addition of mangrove leaf extract is 28. This shows the formulary for making hand soap where the addition of NaCl in the surfactant mixture before adding aquadest with the addition of 10% mangrove leaf extract is the best product according to panelists and consumer organoleptic tests. Keywords: Coastal community, Environmental health, Hand soap making, Mangrove leaf extract, Share Link | Plain Format | Corresponding Author (Dwi Atmanto)

90	Chemistry	ABS-173
Antibacterial and Physical Properties of Kersen (Muntingia calabura) Liquid Soap from Bulk Cooking Oil Chika Shafa Maura (a), Mokhamad Ali Rizqi Maulana (b), Muhamad Athariq (c), Muhammad Fathar Aulia (d), Nisrina Fitri Nur Syamsi (e), Meriana (f), Neneng Siti Silfi Ambarwati (g), Tri Handayani Kurniati (h), Sri Rahayu (i), Yussi Pratiwi (j), Setia Budi (k) a,b,c,d,e) Students of Chemistry Study Program, State University of Jakarta, Indonesia f) Students of Chemistry Education Study Program, State University of Jakarta, Indonesia g) Cosmetology Study Program, State University of Jakarta, Indonesia h,i) Biology Study Program, State University of Jakarta, Indonesia j,k)Chemistry Study Program, State University of Jakarta, Indonesia setiabudi[at]unj.ac.id Abstract Efforts are needed to overcome the problem by changing the oil into useful side products. This study aims to determine the physical quality and antibacterial activity against staphylococcus aureus and Escherichia coli liquid soap from bulk cooking oil with ethanol extract of Kersen leaf. The method used is an experimental method with concentration variation. The soap.was tested for antibacterial activity using the disc diffusion method with soap concentration variation of 3%- 5%-7%- 9%-11%. Physical parameters of free alkali, moisture content, foam height, pH was done with kersen extract variation of 0.5%-1%- 1.5%- 2%- 2.5%-3%. Result suggest that concentration of 3% and 5% kersen leaf extract has been optimum condition for antibacterial activity, whilst concentration of 0.5% and 2.5% kersen leaf extract has been approved to have optimum physical characteristic of the soap. In the pH test with the addition of 1.5%- 2%- 2.5%- 3% kersen leaf extract met SNI. In conclussion the soap from bulk cooking oil added with ethanol extract of kersen has antibacterial activity and good physical properties. Keywords: antibacterial, kersen, bulk, oil, soap Share Link | Plain Format | Corresponding Author (Chika Shafa Maura)

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