Microwave Assisted Synthesis of Coumarin 3-carboxylate Through Knoevenagel Condensation with Aluminum Chloride Catalyst
Syifa Aulia Mumpuni, Hanhan Dianhar, Fera Kurniadewi, Zulhipri

Chemistry, Universitas Negeri Jakarta
Jl. Rawamangun Muka Raya No. 11, Jakarta Timur 13220, Indonesia

Abstract

Coumarin is a therapeutic agent, found as a natural secondary metabolite in plants, bacteria, fungi, essential oil, and can be chemically synthesized. One of the coumarin derivatives biology activities is as an antimicrobial. This study aims to do coumarin synthesis with microwave assisted synthesis method via Knoevenagel condensation. Which, coumarin synthesized from stirring 20 mmol of 2-hydroxy-benzaldehyde and 24 mmol of diethyl malonate without solvent (solvent-free) and then adding aluminum chloride catalyst, put it in the microwave for 10 minutes with an interval of 10 second. This synthesis monitored with Thin Layer Chromatography (TLC) with n-hexane and ethyl acetate (8:2) as the eluent. Purification is done by recrystallization. Synthesis product then tested for its melting point and also characterization with UV-Vis spectroscopy.

Keywords: coumarin, synthesis, Knoevenagel condensation, microwave assisted, solvent-free

Topic: Chemistry