SYNTHESIS OF A CHALCONE DERIVATIVE FROM VANILLIN USING MICROWAVE IRRADIATION METHOD Pandu Rizki Triananda, Hanhan Dianhar, Fera Kurniadewi, Zulhipri
Chemistry, Universitas Negeri Jakarta
Jl. Rawamangun Muka Raya No. 11, Jakarta Timur 13220, Indonesia
Abstract
Chalcone compound is one of derivatives of flavonoid and reported to have many bioactivity such as antibacterial, anticancer, antioxidant, and anti-inflammatory. The broad use of chalcone continuously supports research on chalcone synthesis and its bioactivity. Microwave-assisted organic synthesis is used due to its capability on making less reaction time, easy work up and cleaner products. Synthesis of a chalcone derivative from vanillin and 4-hydroxyacetophenone has been carried out by means of a Claisen-Schmidt condensation to obtain 3-(4-hydroxy-3-methoxyphenyl)-1-(4^-hydroxyphenyl)-2-propen-1-on with a base catalyst using the microwave irradiation method. The product was appeared in a yellow solid with a yield of 80,65% and a melting point of 112 degree celcius. The UV spectrum of the synthesized chalcone showed a maximum absorption at a length of 358 nm and 270 nm which falls within the specific regional range for chalcone.
