Page 7 (data 181 to 210 of 283) | Displayed ini 30 data/page
<< PREV 1 2 3 4 5 6 7 8 9 10 NEXT >>

181	Nursing Management and Education	ABS-246
FACTORS INFLUENCING DEPRESSION IN NURSING STUDENTS: A SYSTEMATIC LITERATURE REVIEW Cifanelda Deborah(a)- Anni Oktavia Marbun(a)- Asril Syamrio Tinambunan(a)- Juniarta(b*)- Ester Silitonga(c) a) Students, Faculty of Nursing, Universitas Pelita Harapan b) Lecturer, Faculty of Nursing, Universitas Pelita Harapan c) Clinical Educator, Faculty of Nursing, Universitas Pelita Harapan Jl. Boulevard Jend. Sudirman no 15A *juniarta.sinaga[at]uph.edu Abstract Depression is a mental health problem that can cause a decrease in one^s productivity, cognitive and psychomotor capability, initiative ability, as well as may lead to suicidal thoughts or attempts. The World Federation for Mental Health (WFMH) in 2012 reported about one in 20 people who had episodes of depression began at an early age. A fact in Indonesia in year 2017 reported that 27.3% of nursing students had moderate to severe depression. Several studies showed that the incidence rate of depression in nursing students was higher compared to the other students. This study aimed to identify factors contributing to the incidence of depression in nursing students from empirical literatures. This study applied a systematic literature review, using four databases including PubMed, Science Direct, Google Scholar and EBSCO Some keywords were used such as ^influence factors^, ^depression^, ^nursing students^, ^depression factors and nursing students^. The retrieved articles were appraised using the Critical Appraisal Tools from Joanna Briggs Institute (JBI). A PRISMA flow diagram was used to display the selection process of the literatures and the data was analyzed using a simplified thematic approach. This study revealed six themes and 20 sub themes related to factors contributing depression in nursing students. The factors included personal, biological, psychological, family, social and academic factors. Understanding contributing factors of depression might lead students to be aware of their own conditions in which could further empower students to decide a positive stress coping such as by asking for help in the professional counselling session. It is expected that educational institutions should provide sufficient attention to the emotional health of the students, by implementing a counseling or mentoring for students who are needed. Keywords: Depression- Nursing Students Share Link | Plain Format | Corresponding Author (Juniarta Juniarta)

182	Nursing Management and Education	ABS-252
Changes in Situation of Community Life to Deal with COVID-19 Pandemic in North Sumatra Reni Asmara Ariga1*, CholinaTrisa Siregar2, Siti ZaharaNasution3, Lufthiani4, Fajar Amanah Ariga5, Ikhsanuddin Ahmad6 Universitas Sumatera Utara Abstract Objective: Identify the impact of changes that have occurred due to the COVID-19 pandemic in the people of North Sumatra. Method: Descriptive, with cross sectional approach, total sampling was 1,008 respondents in North Sumatra from May to June 2020. Research used google form contains open questions apropos aspects of activity, environmental, spiritual, psychological, physical, health and economic. The data analysis used was descriptive analysis. Researchers have obtained approval from USU Nursing Health Research Ethics Commission and have obtained informed consent from each respondent. Results: Result of this research was about changed in situation of people^s lives in dealing with Covid 19 pandemic in North Sumatra: Activities 117 respondents (11.60%), Environment 85 respondents (8.43%), Spiritual 23 respondents (2.28%), Psychic 619 respondents (61.40%), Physical 12 respondents (1.19%), Health 64 respondents (6.35%), and Economy 88 respondents (8.73%). The most frequent changed in society were in psychological aspects and the smallest changed in community were physical aspects. Conclution: A change in situation of people^s lives to deal with COVID-19 pandemic in North Sumatra. Keywords: Life Situation, Society, Pandemic, COVID-19 Share Link | Plain Format | Corresponding Author (Reni Asmara Ariga)

183	Nutrition and Functional Food	ABS-265
Early Nutritional Detection for CVD Risk in Young Women Dwipajati(a), Annisa Rizky Maulidiana(b) (a)Nutrition Depatment, Poltekkes Kemenkes Malang, Indonesia, Phone (0341) 551893. Fax (0341) 566075. Email: dwipajati[at]yahoo.co.id (corresponding author) (b)Nutrition Department, Faculty of Medicine, Universitas Brawijaya, Indonesia. Phone (0341) 569117. Fax (0341) 564755 Abstract Background: Cardiovascular disease (CVD) has been the leading cause of death among other non-communicable diseases in Indonesia. Dietary pattern and lifestyle changes are the main factors of CVD risk of the women in the middle age. Objectives: To investigate the association between nutritional status factors and CVD incident in young women. Methods: An observational study, cross-sectional design of 160 young women aged 20-22 years who studied in one of the Health University in Malang City, East Java. Body Mass Index (BMI), waist circumference (WC)) and body fat percentage (BF%) were measured in one-time session. Dietary intake estimation was measured in 12 meal times in a week. All variables were categorized into quartiles based on the waist-to-height ratio (WHtR) as CVD risk indicator. Multinomial logistic regression was performed to estimate the association between nutritional status and the CVD risk. Results: Overall, energy and other macronutrients intake were lower than daily requirements (p<0.001). BMI, WC, and %body fat was significantly different across the WHtR percentiles (p<0.001), with the highest mean value found in the highest percentile (76-100th percentile). Higher BMI (OR:1.81; 95% CI 0.89-3.70; p=0.104) and WC (OR:5.88; 95% CI 3.48-9.93; p<0.001) were associated with higher risk of CVD (76-100th percentile). While %E from fat intake (OR:0.89; 95% CI 0.81-0.99; p=0.03) was associated with medium risk (25-50th percentile). Conclusion: BMI, WC and %E from fat intake may be the early nutritional detection indicators for CVD risk in young women. Keywords: BMI; CVD risk; Dietary Intake; Waist Circumference; Young Women Share Link | Plain Format | Corresponding Author (Dwipajati Dwipajati)

184	Nutrition and Functional Food	ABS-30
Impact of Menstrual Blood Loss on Hemoglobin Levels among Adolescent Girls in Banyumas Izka Sofiyya Wahyurin, Hiya Alfi Rahmah Universitas Jenderal Soedirman Abstract Introduction: Excessive menstrual blood loss (MBL) is the most common symptomatic disorder in the menstrual cycle. It is a major cause of anemia in adolescent girls. Blood loss during menstruation shows the loss of iron stores quickly due to the amount of blood that comes out while the longer a woman experiences menstruation, the more blood comes out and the more iron deposits are lost. Objective: To investigate the relationship between menstrual blood loss (MBL) and adolescent girls hemoglobin levels in Banyumas. Methods: The study used a cross-sectional design with a sample of 170 students at Banyumas Vocational School. The menstrual blood loss was obtained using the menstrual pictogram questionnaire and the hemoglobin level expressed in g / dL units using the Hb Quick-Check tool. Analysis of data using a chi-square and linear regression test. Results: There was statistically significant between menstrual blood loss with hemoglobin level (OR: 2.09- CI95% : 0.18-23.8- p: 0.048). Increasing the menstrual blood loss by 10 ml will reduce the hemoglobin level by 1.2 mg / dL. Conclusion: There was significant relationship between menstrual blood loss and iron deficiency among adolescent girls in Banyumas. Keywords: menstrual blood loss, hemoglobin levels, adolescent girls Share Link | Plain Format | Corresponding Author (Izka Sofiyya Wahyurin)

185	Nutrition and Functional Food	ABS-36
THE INFLUENCE OF INSTAGRAM CULINARY ACCOUNT (FOODSTAGRAM) EXPOSURE TO FOOD CHOICE IN ADOLESCENTS AT SMA NEGERI 1 PURWOKERTO Khansa Nabila Fauzi (a*), Atikah Proverawati (b), Izka Sofiyya Wahyurin (b) (a) Student of Nutrition Science, Faculty of Health Sciences, Jenderal Soedirman University *khansanabilafz[at]gmail.com (b) Departement of Nutrition Science, Faculty of Health Sciences, Jenderal Soedirman University Abstract Background: As many as 73.2% of high school students often use gadgets to access social media. Food photos on Instagram can effect on food choices. Food photos uploaded on Instagram are generally foods that contain lots of sugar, fat, and salt. This study aimed to know the influence of Instagram culinary account (foodstagram) exposure to food choice in adolescents at SMA Negeri 1 Purwokerto. Methods: This study was a cross sectional with 51 students as respondents. Data retrieval of Instagram culinary accounts (foodstagram) exposure was taken using Google Form questionnaire and food choice data was taken with Food Frequency Questionnare (FFQ). Data was analyzed by Chi-Square test. Results: The results showed that respondents who were actively exposed to Instagram culinary accounts (foodstagram) (n = 26) were more than respondents who were passively exposed to Instagram culinary accounts (foodstagram) (n = 25) and respondents who often consume food uploaded in Instagram culinary accounts (n = 23) were lower than respondents who rarely consume food uploaded in Instagram culinary accounts (n = 28). The influence of Instagram culinary account (foodstagram) exposure to food choice in adolescents at SMA Negeri 1 Purwokerto in this study was no statistically significant effect (p = 0.065). Conclusion: There was no effect of Instagram culinary account (foodstagram) exposure to food choice in adolescents at SMA Negeri 1 Purwokerto. Keywords: Foodstagram; Food choice; Adolescent Share Link | Plain Format | Corresponding Author (Khansa Nabila Fauzi)

186	Nutrition and Functional Food	ABS-38
Yellow watermelon-plantain banana juice as protective factor of oxidative stress and source of energy during exercise Afina Rachma Sulistyaning (a*), Farida (a), Hesti Permata Sari (a) a) Nutrition Science Study Programme Universitas Jenderal Soedirman Jln. Dr. Soeparno, Karangwangkal *) afina.sulistyaning[at]unsoed.ac.id Abstract In some conditions, additional food administration prior to exercising is required to ensure glucose availability in the serum as the source of energy. Additional food must also contains antioxidant to help alleviate oxidative stress formation during exercise. This study aiming to investigate yellow watermelon-plantain juice administration prior to anaerobic exercise on blood glucose level and its protective effect on markers of oxidative stress formation. 35 male Sprague Dawley rats were divided into positive control group, negative control group, P1 (single-dose of juice), P2 (double-dose of juice), and P3 (single-dose with 0.27 grams additional granulated sugar). Blood glucose level in treatments groups were examined before juice administration, 30 minutes after juice administration, and after exercise test. Malondialdehyde level were examined after exercise test. There was a significant different of blood glucose level in treatment groups before and after exercise (p<0.05). P2 groups has the highest blood glucose level before and after exercise (111.86 mg/dl and 100.52 mg/dl). Mda level differ significantly between groups (p<0.05) with negative control group has the highest level of Mda (7.68 nmol/ml) and P2 has the lowest level among treatment groups (1.8 nmol/ml). It can be concluded that yellow watermelon-plantain juice administration prior to anaerobic exercise was an effective source of energy due to its rapid glucose availability in the serum. Antioxidant content in yellow watermelon-plantain juice effectively offer protective effect towards oxidative stress formation during exercise. Keywords: Yellow watermelon; plantain; exercise; energy source; antioxidant Share Link | Plain Format | Corresponding Author (Afina Rachma Sulistyaning)

187	Nutrition and Functional Food	ABS-43
The Effects of Fish Oil Supplemented Nutrition on the Levels of Omega-3 Fatty Acids, Inflammatory Mediators and Tissue Healing in Rats with Full Thickness Burn Injury Shamsul Kamaruljan Hassan, Rhendra Hardy Mohamad Zaini, Ahmad Sabri Sharif, Wan Fadzlina Wan Muhd Shukeri Universiti Sains Malaysia Abstract Background: Literature around supplementation of fish oil is found to be lacking in the burn injury population. This study was conducted to investigate the effects of fish oil supplemented nutrition on the levels of omega-3 fatty acids, inflammatory mediators and tissue healing in rats with full thickness burn injury (FTBI). Methods: Thirty male Sprague-dawley rats weighing between 350 to 400 grams subjected to FTBI were randomized into either the experimental group (n = 15), that received standard diet supplemented with fish oil 2.5 ml/kg/day intravenously, or the control group (n = 15), that received standard diet only. Blood levels of omega-3 fatty acids (docosahexanoic acid [DHA] and eicosapentaenoic acid [EPA]), anti-inflammatory cytokine (interleukin-10) and pro-inflammatory cytokine (interleukin-12) were measured at baseline, 5, 10 and 21 days. Five rats from each group were euthanized at day 5, 10 and 21 days and their burned tissues were biopsied for histological examination. Results: At 21 days, the mean changes from baseline of DHA were 82.80 (95% CI, 57.35 to 108.24) ng/mL in the experimental group versus 2.35 (95% CI, -23.09 to 27.79) ng/mL in the control group (P = 0.002). Meanwhile, the mean changes from baseline of EPA was 27.17 (95% CI, 23.37 to 30.97) ng/mL in the experimental group versus 1.00 (95% CI, -2.80 to 4.80) ng/mL in the control group (P <0.001). At 10 days, the mean changes from baseline of interleukin-10 were 0.06 (95% CI, 0.03 to 0.10) ng/mL in the experimental group versus -0.01 (95% CI, -.04 to 0.03) ng/mL in the control group (P = 0.018). Meanwhile, the mean changes from baseline of interleukin-12 were -0.07 (95% CI, -0.14 to -0.01) ng/mL versus 0.02 (95% CI, -.04 to 0.09) ng/mL in the control group (P = 0.04). These changes were not statistically significant at 21 days. Histological examination showed no significant differences in the granulation tissue thickness and epidermal thickness between the two groups. Conclusion: Fish oil supplemented nutrition resulted in a significantly higher level of omega-3 fatty acids, DHA and EPA, in rats with FTBI. Supplementation of the fish oil increased the level of anti-inflammatory cytokine, interleukin-10, while decreased the level of pro-inflammatory cytokine, interleukin-12, suggesting its immuno-modulatory effect in burn. In this study, fish oil supplementation did not increase the rate of tissue healing. Keywords: Immunonutrition; Fish oil; Burn Share Link | Plain Format | Corresponding Author (WAN FADZLINA WAN MUHD SHUKERI)

188	Nutrition and Functional Food	ABS-72
HEALTH EDUCATION ENHANCES THE UNDERSTANDING OF PREGNANT WOMEN TOWARDS THE PREVENTION OF EARLY COMPLEMENTARY FEEDING Meivita Dewi Purnamasari (a*), Iftiar Alif Nuraeni (b), Erni Setiyowati (a), Koernia Nanda Pratama (a), Galih Noor Alivian (a) a. Department of Pediatric Nursing, Faculty of Health Sciences, Jenderal Soedirman University b. Student of Nursing Department, Faculty of Health Sciences, Jenderal Soedirman University Abstract Background: Starting to give complementary feeding at the right time is very beneficial for meeting the nutritional needs and development of infants. Giving complementary feeding depends on the mothers knowledge and attitude. Health education is a way to increase the understanding and readiness of mothers in efforts to prevent the provision of early complementary feeding in infants. Purpose: The purpose of this study was to analyze the effect of health education with leaflets on the attitude of preventing early complementary feeding in third trimester pregnant women. Methods: The study design was a quasi-experimental with two groups pre-post test design, with a sample of 66 third trimester pregnant women taken by consecutive sampling. Result: The results showed that there were significant differences in maternal attitudes before and after the provision of health education related to the attitude of prevention of early complementary feeding (p value <0.001). Conclusion: This study recommends the provision of health education about complementary feeding for mothers during exclusive breastfeeding as a step to prevent the provision of early complementary feeding and increase maternal readiness before the period of giving complementary feeding Keywords: complementary feeding, baby, pregnant women, mothers attitude Share Link | Plain Format | Corresponding Author (Meivita Dewi Purnamasari)

189	Nutrition and Functional Food	ABS-85
Food Consumption and Nutrient Density of Adults Male Aged 19-49 Years Old in Indonesia Teguh Jati Prasetyo, Izzati Nur Khoiriani, Katri Andini Surijati Nutrition Study Program, Faculty of Health Sciences, Jenderal Soedirman University Abstract The objectives of this study was to analyze food consumption and nutrient density of adults male aged 19-49 years old in Indonesia. This study was carried out through analyzing a consumption data set of Total Diet Study (SDT) of Indonesian Ministry of Health which were collected using 24-hour food recall method. The final subjects included for this study were 26268 male. The nutrients adequacy were assessed based on Institute of Medicine calculation. The nutrients analyzed include energy, protein, calcium, iron, zinc, vitamin A and vitamin C. The average food consumption of Indonesian adult male population is mostly from the grains food group of 305.0 g. The food group that was consumed the least by the adult population was oily seeds as much as 18.1 g. The adequacy of energy, protein, calcium, iron, zinc, vitamin A and vitamin C were 81.4%, 108.3%, 105.5%, 159.4%, 64.8%, 107.7% and 54.6%, respectively. The nutrient density of protein, Ca, Zn, vitamin A and vitamin C were still under the recommendation. It means that food consumption quality of Indonesian adults need to be improved. Considering the inadequate intake of some micronutrients in Indonesian adults women, it is necessary to increase the consumption of animal food, legumes, fruits and vegetables as sources of micronutrients. Keywords: adult male ,food consumption, nutrient density, and nutritional adequacy Share Link | Plain Format | Corresponding Author (Teguh Jati Prasetyo)

190	Nutrition and Functional Food	ABS-88
Differences of Food Patterns, Physical Activity, and The Abdominal Fat Distribution Before and After Ramadhan Fasting in Overweight and Obese Students of Jenderal Soedirman University Dika Betaditya 1, Friska C Agustia 1, Gumintang R Ramadhan1, Yovita P Subardjo1, Rosswandari M Widyananda2, dan Netha Nabila2 1 Lecture, Department of Nutrition and Science, Faculty of Health Sciences, Jenderal Soedirman University, Jl. dr. Soeparno Street, Karangwangkal, Purwokerto 53123, Indonesia, Email: dika.betaditya[at]gmail.com (corresponding author) 2 Student, Department of Nutrition and Science, Faculty of Health Sciences, Jenderal Soedirman University, Jl. dr. Soeparno Street, Karangwangkal, Purwokerto 53123, Indonesia Abstract Background: Muslims during Ramadan fasting for 13-14 hours per day. This condition was affected eating patterns (intake of energy, protein, fat, carbohydrates, fluid, eating frequency) and their physical activity. The accumulation of excess fat in the abdomen occured when there was not balance of intake energy and physical activity, that was occured in people who had overweight and obese in nutritional status. Purpose: This study aimed to analyze the differences of food patterns, physical activity, and the abdominal fat distribution before and after ramadhan fasting. Methode: Total respondent in this research were 56 students Jenderal Soedirman University who had overweight and obese nutritional status. All respondents were taking with purposive samping methode. This research used an experimental study with one group pre-test and post-test design and followed by a paired T-test for statistical analyze. Results: There were significant differences in energy intake, carbohydrates, fat, body weight, body mass index, physical activity, abdominal circumference, waist and hip circumference ratio (WHCR), and suprailiac fat thickness before and after fasting (p <0.05). There were no significant differences in protein, fluid, and abdominal fat thickness before and after fasting (p> 0.05). Conclusion: Ramadan fasting can affected food intake, physical activity and the abdominal fat. Keywords: Ramadhan Fasting, food intake, physical activity, and abdominal fat distribution Share Link | Plain Format | Corresponding Author (DIKA BETADITYA, S. Gz., M.P.H.)

191	Nutrition and Functional Food	ABS-90
The Potential of Mung Bean Milk Yogurt as a Prevention of Atheroma in Obese Women Hery Winarsi1*, Gumintang R Ramadhan1, Widya Ayu Kurnia Putri1, Afina Rachma Sulistyaning1, and Farida1 1Department of Nutrition Science, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, 53123, Central Java, Indonesia *Corresponding author: winarsi12[at]gmail.com Abstract Background: Obesity is generally supported by atherogenic lipids, and susceptible to developing coronary heart disease. Purpose: This study aims to determine the effect of giving Mung bean milk yogurt (Mungbe-Yo) to changes in atherogenic index (AI), body mass index (BMI), and abdominal circumference of obese women. Methods: Mungbe-Yo was made by the proportion of 85% Mung bean milk, 15% skim milk, and added 5% sucrose and 2% BAL of the total volume. A total subject of 20 women aged 20-30 years, are obese (BMI> 27 kg/m2), live on campus, circumference > 80 cm, and are willing to sign informed consent. Subject was divided into two randomly, 10 people each; group I, were given Mungbe-Yo, while II, were given a placebo, as much as 200 mL/day for 1 month. Before and after the intervention blood samples were taken to test of atherogenic index, weighed their body weight, and measured their abdominal circumference. Testing data used the Independent T-test if the distribution was normal, or the Mann Whitney test if the data were not normally distributed. Results: Mungbe-Yo decreased of AI (P = 0.0006), abdominal circumference (P = 0.04), and BMI (P = 0.83). Conclusion: Mungbe-Yo could prevent the formation of atheroma in obese women, and preventing its development towards coronary heart disease. Keywords: Mung bean milk yogurt, atherogenic index, circumference, atheroma, obesity Share Link | Plain Format | Corresponding Author (Hery Winarsi)

192	Nutrition and Functional Food	ABS-108
Correlation between Age, Knowledge, Level of Education with Nutritional Behavior in Facing the Covid-19 Pandemic in Bengkulu Province Miratul Haya(a*), Emy Yuliantini(a),Andi Eka Yunianto(b), Ahmad Faridi(c) a)Department of Nutrition, Bengkulu Health Polytechnic, Bengkulu, Indonesia b)Department of Nutrition, Faculty of Health Science, Siliwangi University, Tasikmalaya, Indonesia c)Department of nutrition, Faculty of Health Science, Muhammadiyah Prof. Dr. Hamka University, Jakarta, Indonesia Abstract Background: Healthy eating during the Coronavirus Pandemic (Covid-19) is important for maintaining a healthy body. Eating patterns that need attention are the consumption of vegetables, fruit, sugar, salt, fat, and water. Objective: The study aims to analyze the relationship between age groups, knowledge, and education level with the nutritional behavior of Bengkulu people in the face of the Covid-19 pandemic. Methods: This study used a cross-sectional design with a sample of 966 people aged 16 years and over and residing in Bengkulu Province. Questionnaire in the form of e-survey with google form. Chi-square test was used to analyze the relationship between age groups, knowledge, and education level with nutritional behavior Results: The results showed that 85.2% of respondents in the age group aged under 25 years had poor nutritional behavior. More than 50% of respondents consume fruits and vegetables as well as salt, oil, and sugar that were not following good nutritional behavior. 98.2% of respondents thought that Covid-19 would eventually be successfully controlled. Age (OR = 1,588; 95% CI: 1,032 - 2,444) was significantly related to nutritional behavior while knowledge (OR = 0.862; 95% CI: 0.322-2303) and education level (OR = 1,297; 95% CI: 0.910 - 1,849) were not related to nutritional behavior. Conclusion: There is a relationship between age and nutritional behaviour. Good nutritional behavior needs to be applied to the age group aged under 25 years to prevent and reduce transmission of the COVID-19 outbreak. Keywords: Age, education level, nutritional behavior, COVID-19 pandemic Share Link | Plain Format | Corresponding Author (Miratul Haya)

193	Nutrition and Functional Food	ABS-113
Energy Deficiency and Protein Intake Related to Stunting and Motor Development in Children Aged Under 5 Years: Cross-Sectional Study in Kaway XVI, Aceh Barat District Suryana(a*), Fitria Nur(a), Yulia Fitri(a), Silvia Wagustina(a), Andi Eka Yunianto(b) a)Department of Nutrition, Aceh Health Polytechnic, Aceh, Indonesia b)Departement of Nutrition, Siliwangi University, Tasikmalaya, Indonesia Abstract Background: Food consumption is an important factor that can affect the nutritional status and development of children. The quality of children can be reflected in their nutritional status and development. Method: This study used a cross-sectional design, with a total sample of 81 people. Samples were toddlers aged 24-59 months, selected by using the technique of random sampling. The study was conducted in Kaway XVI District, West Aceh Regency. Chi-square test was used to analyze the relationship of energy and protein intake to the incidence of stunting and child development. Results: Children under five with a prevalence of stunting 49.4%, fine motor development doubted 55.6%, gross motor development doubted as much as 17.3%. Children who were stunting tend to have energy intake in the category of severe deficits (83.3%), compared to children who were not stunting (80.0%). Children who were stunting tend to have a heavy protein deficit intake (88.9%), compared to children who were not stunting tend to have a mild protein deficit intake (66.7%). There was a significant relationship between energy intake (p-value = 0.002) and protein (p-value = 0.003) to the incidence of stunting. There was an influence of energy intake (p-value = 0.000), but it did not affect the intake of protein (p-value = 0.922) on the motor development of toddlers. Conclusion: Energy and protein intake influence the incidence of stunting in children under five in Kaway XVI District, West Aceh Regency. Energy intake affects the motor development of children but does not affect protein intake. The government is expected to design appropriate policies to improve the nutritional status and quality of children. Keywords: Energy, protein, stunting, motor development, children Share Link | Plain Format | Corresponding Author (Suryana Suryana)

194	Nutrition and Functional Food	ABS-118
Iron Supplementation Improves Ferritin and Zinc Blood Levels (In Vivo Study) Hesti Permata Sari (a*), Farida (a), Afina Rachma Sulistyaning (a), Ibnu Zaki (a) a) Nutrition Study Program, Faculty of Health Sciences, Universitas Jenderal Soedirman Jalan Dr. Soeparno, Karangwangkal, Purwokerto * hesti.sari[at]unsoed.ac.id Abstract Background.Iron deficiency anemia is a major nutritional problem in Indonesia. Prevalence of iron deficiency anemia is found in adolescent girls which is equal to 48.9%. One of the available effort to alleviate this condition is iron supplementation. However, inconsistency reports regarding iron supplementation effect towards other micro mineral such as zinc still persist.Studies show that daily iron supplementation in 284 Indonesian infants lowers serum zinc levels after supplementation. Another opposite study is that iron supplementation of 50 mg increases serum zinc levels.Objective. This study aims to determine various doses of TTD supplementation effect on ferritin and zinc levels in anemic Sprague Dawley rats. Methods. True experimental was used as a research design with pre-post test control group design. 30 female Sprague Dawley white rats used in this study were divided into 5 groups, which are K+, K-, P1, P2, and P3, followed by various doses of iron supplementation for 14 days with standard feed AD II comfeed. The data were analyzed using one way anova test followed by LSD post hoc test. Results. The results showed a significant difference in ferritin and zinc levels in each group after receiving iron supplementation. The highest increase of ferritin and zinc blood levels occurred in P3 group(2.16mg of iron supplementation dosage) with the difference3,4 ng/ml and 0,64 mg/L of ferritin and zinc blood levels respectively. Conclusion. In conclusion, the administration of iron supplementation can increase both ferritin and zinc blood levels in anemic rats, although the numberdepends on the dosage and duration of TTD supplementation. Keywords: Ferritin serum; Zinc; Iron supplementation; Anemic rats Share Link | Plain Format | Corresponding Author (Hesti Permata Sari)

195	Nutrition and Functional Food	ABS-120
Community Lifestyle in Preventing and Facing the Covid-19 Pandemic in Bengkulu Province Emy Yuliantini(a*),Andi Eka Yunianto(b),Miratul Haya(a),Bela Aditia (a), Ahmad Faridi(c) a)Department of Nutrition, Bengkulu Health Polytechnic, Bengkulu, Indonesia b)Department of Nutrition, Faculty of Health Science, Siliwangi University, Tasikmalaya, Indonesia c)Department of nutrition, Faculty of Health Science, Muhammadiyah Prof. Dr. Hamka University, Jakarta, Indonesia Abstract Background: During the Pandemic Covid-19 Period, we have to improve the immune system which is the bodys defense force against bacteria, viruses, and disease-causing organisms by adopting a good lifestyle. Objective: This study is to look at peoples lifestyles in preventing and dealing with the Covid-19 pandemic. Methods: This study used a cross-sectional design with a sample of 966 people aged 16 years and over and residing in Bengkulu Province. Questionnaire in the form of e-survey with google form. Chi-square test was used to analyze the relationship between the consumption of vegetables, fruit, and exercise habits on gender. Results: The results showed that the lifestyle of respondents 28% smoked, 37.4% consumed vegetables and fruit every day, 80% rarely exercised. There was a significant relationship between smoking (OR = 3,484- 95% CI: 1,573 - 7,716), vegetable and fruit consumption (OR = 1,509- 95% CI: 1,021 - 2,229) while there was no relationship between exercise habits (OR = 1,231- 95% CI : 0.768 - 1,971) against gender. Conclusion: There was a lifestyle relationship such as smoking, consumption of vegetables, and fruit in the community during the Covid-19 pandemic. A good lifestyle is very much needed for the community and the government needs support in increasing the provision of education in preventing and reducing the transmission of the COVID-19 outbreak. Keywords: Consumption of vegetables and fruits, sports, lifestyle, gender, smoking Share Link | Plain Format | Corresponding Author (Emy Yuliantini)

196	Nutrition and Functional Food	ABS-135
METABOLIC SYNDROME PREVALENCE IN UNIVERSITY WORKER AND ITS RELATION TO ANTHROPOMETRIC PARAMETER Yovita Puri Subardjo, Friska Citra Agustia, Dika Betaditya, Gumintang Ratna Ramadhan, Noor Cherinawati Nutrition Science Department, Jenderal Soedirman University Abstract Trend and prevalence of non-communicable disease in Indonesia has risen. Metabolic syndrome predicts the development of metabolic disease such as type 2 diabetes and cardiovascular disease. Workers have a risk for metabolic syndrome due to less physical activity and high carbohydrate and fat consumption. Diagnose of metabolic syndrome needs a high cost to be known periodically rather than anthropometric measurement. This study was aimed to get a prevalence of metabolic syndrome among workers and found the most related anthropometric parameter to metabolic syndrome. A total of 80 subjects has enrolled to a cross sectional study. The subjects were measured of anthropometric parameters and metabolic syndrome components. We got the correlation of anthropometrics parameter with metabolic syndrome components by Pearson and Spearman analysis, and multivariate analysis. Results showed the prevalence of metabolic syndrome among workers was 31.25%. The increase in the following anthropometric variable values indicates an increase of metabolic syndrome component as follows: waist-to-hip ratio to triglyceride levels; abdominal circumference to blood pressure; body mass index against triglyceride levels abdominal circumference; percent body fat against abdominal circumference and fasting blood sugar. The interaction of percent body fat combine with upper arm circumference determinate the increase of triglyceride levels 13%. The interaction of waist-to-hip ratio with and body mass index determinate the increase of abdominal circumference 81%. An increase of anthropometric parameters can be used to assess an increased component of metabolic syndrome. Keywords: anthropometry, metabolic syndrome, prevalence, worker Share Link | Plain Format | Corresponding Author (Yovita Puri Subardjo)

197	Nutrition and Functional Food	ABS-141
THE EFFECTIVENESS OF DASH DIET COUNSELING (Dietary Aproaches to Stop Hypertension) ON BLOOD PRESSURE, KNOWLEDGE, POTASSIUM AND SODIUM INTAKE FOR HYPERTENSION PATIENTS Yulia Fitri, SST, M. Biomed,(a*), Suryana, SP., M.Si (a) Nutrition Department of Poltekkes Ministry of Health, Aceh Abstract Background : Prevalence of Hypertension is on of deseases whose prevelance continous to increase every year. Based on measurements in Aceh Province in 2018 its known that more 22,2 % people aged more 18 years old suffer of hypertention. Uncontrolled blood pressure in hypertension patients will development into cardiovascular disease (heart, stroke, kidney). One way to controlling blood pressure in hypertension patients is provide DASH diet counseling. Methodology: The study was a pretest and posttest observation using Quasi-experimental design. The study samples were 28 sampel (14 with Counseling DASH DIET and 14 without Counseling DASH DIET ). The measurment of design to see the effect of nutritional counseling with DASH diet on blood pressure, knowledge, sodium and potassium intake of hypertensive patients, in August to September 2019. Total sample of this study was 28 samples (14 with treatment and 14 without treatment). Results: After being given counseling on the sample we founded of changes on knowledge, sodium intake and potassium intake, where the average increase on knowledge, decreased systolic blood pressure and decreased diastolic , decreased sodium intake ) and increased of potassium intake after treatment. Conclusion: There are an effect of DASH diet counseling on knowledge, sodium and potassium intake, but does not affect blood pressure. Keywords: DASH diet counseling, blood pressure, knowledge, sodium and potassium intake. Share Link | Plain Format | Corresponding Author (Yulia Fitri)

198	Nutrition and Functional Food	ABS-173
The Availability of Energy and Nutrients in Food Service Provided in ASIFA (Aji Santoso International Football Academy) Arsinah Habibah Fitriah (a*), Carissa Cerdasari (b) a) Nutrition Department, Poltekkes Malang Jalan Besar Ijen No. 77 C Malang 65119, Indonesia *arsinahfitriah[at]gmail.com b) Nutrition Departement, Poltekkes Malang Jalan Besar Ijen No. 77 C Malang 65119, Indonesia Abstract Background: Football in Indonesia is one of the most popular sports. It is under the guidance of the Indonesian Football Organization (PSSI). Unfortunately, when competing at the international level, the Indonesian football team has not achieved the expected achievements due to players height and posture that are not comparable to opponents. This low performance might be closely related to the common phenomenon in soccer schools where students exercise with high intensity but are not supported by proper intake. Objective: This study aimed to assess the availability of energy and food nutrients served in the food service at ASIFA. Design: It was an observational study using a cross-sectional design conducted in December 2019 at ASIFA. The population was all ASIFAs students aged 11-20 years, and the sampling technique used was a total sample with the sample size 105 people. Results: Energy and nutriens availability was assessed by calculating the nutritional content of food served during eleven days of research in the form of the average value of energy and nutrients to be compared to the average needs of students based on age group so that it obtained the percentage of energy and nutrients availability of students of age group 10 - 12 years (Energy 101.9%, Protein 106.1%, Fat 105.3%, Carbohydrates 96.7%), age group 13-15 years (Energy 92.7%, Protein 96.5%, Fat 95.9%, Carbohydrates 91.1%), age group 16-18 years (Energy 97.1%, Protein 101.1%, Fat 100.4%, Carbohydrates 92.2%), and age group 19-29 years (Energy 98.6%, Protein 102.6%, Fat 101.9%, Carbohydrates 93.6%). Conclusions: The availability of energy, protein, and fat in students aged 10-12 years was already following the needs, while carbohydrates were still lacking. For students aged 13-15 years, the availability of energy and all nutrients was still lacking, which wasin the range of 70- <100%. While in students aged 16-18 and 19-29 years, the availability of energy and carbohydrates again did not meet the needs. Therefore, it is necessary to increase the availability of energy and nutrients by around 10% to meet the nutritional needs of ASIFA students in all age groups. Keywords: The availability of nutrients and energy, energy and nutrients needs, food service, football school Share Link | Plain Format | Corresponding Author (Arsinah habibah Fitriah)

199	Nutrition and Functional Food	ABS-211
Dietary Density Energy in women aged 19-20 years Widya Ayu Kurnia Putri, Ibnu Zaki universitas Jenderal Soedirman Abstract Obesity and overweight rates are increasing worldwide. obesity and overweight is a global problem with many contributing factors including dietary energy density (DED). High energy density is a reason for over eating there by increasing the prevalence of overweight. Dietary energy density is used to determine the ratio nutrient to total energy and determined based on comparison of nutrient intake with total energy consumed. This study aim to analyse dietary density energy and verify the relationship between dietary energy density and nutritional status. Observational methods that emphasize cross sectional study using 70 respondents with the age of 19 -29 years. DED was calculated for food records within a week. Calculation of DED is obtained through the total daily food energy consumed by the daily food weight. Nutritional status measured using Body Mass Index. Statistic analysis used rank Spearman. The study found significant corelation between dietary energy density and nutritional status (p < 0,05). Most of subjects had adequate intake density (76 %) Keywords: dietary energy density, obesity, overweighht, DED Share Link | Plain Format | Corresponding Author (Widya Ayu Kurnia Putri)

200	Nutrition and Functional Food	ABS-213
Consumption Patterns Of Iron-Rich Foods Among Rural Adolescents Ibnu zaki1*, Hesti permata sari2, Widya ayu kurnia putri1, afina rachma sulityaning1, farida1,2 1Nutrition Science Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia, 53123 2Dietetic Laboratory and Nutrition Education, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia, 53123 Abstract Background : Iron deficiency is the most prevalent nutritional deficiency in adolescent from the developing world. consumption patterns of iron-rich foods have become one of the main underlying problems. consumption patterns tend to be less. besides that the selection of iron-rich foods is also still not effective Purpose : This study aims to analyze the adequacy of iron consumption compared with the nutritional adequacy. Methods : Analytical cross-sectional study consisting quantitative approaches to data collection and analysis was used in this study. Consecutive sampling technique was adopted and primary quantitative data were collected from 39 adolescent recruited from student of nutrition science study porgram. The primary quantitative data were analyzed using SPSS version 17 software. Results : Average iron consumption of 5.3 mg. When compared with the nutritional adequacy was still below the iron needs. Most consumption of iron-rich foods comes from plant foods. Conclusion : Adolescent iron consumption is still classified as deficit and comes from plant foods. Keywords: adolescent, iron, iron-rich foods, plant foods Share Link | Plain Format | Corresponding Author (Ibnu Zaki)

201	Nutrition and Functional Food	ABS-222
Effectiveness of Combination Juice Yellow Water Melon-Plantain in Increasing Physical Endurance (Study in Sprague Dawley Rats) Farida (a*), Afina Rachma Sulistyaning (a), Hesti Permata Sari (a) a. Nutrition Science Department, Faculty of Health Sciences, Jenderal Soedirman University * farida.140991[at]unsoed.ac.id Abstract Plantain high in potassium and glucose while yellow watermelon high in citrulline, glucose, antioxidant, and fluid. The combination of both can supply abundant glucose and fluid, postponed lactic acid production and inflammation in muscle, so the physical endurance can be longer. This study aims to determine effectiveness of combination juice of yellow watermelon-plantain in increasing physical endurance in Sprague Dawley rats. This study was true experiment, post test only with controlled group design. The subject were 21 male rats Sprague Dawley, divided in to controlled group, P1 group, and P2 group. The dosage of P2 was twice of P1. The subject was given a swimming test. Data were analyzed using the One Way Anova test and the Post Hoc Least Significant Difference test. The average P2 group with the double dosage had the longest physical endurance. There were differences in physical endurance (p <0.05) in each group after being given combination juices with various dosage. Keywords: Physical endurance- plantain- yellow watermelon Share Link | Plain Format | Corresponding Author (Farida Farida)

202	Nutrition and Functional Food	ABS-228
Consumption of Fe-folic acid supplements on hemoglobin levels in pregnant women and infant birth weight Katri Andini Surijati1, Diffah Hanim2, Kusnandar2 1 Nutrition Science, Faculty of Health Sciences, Jenderal Soedirman University. Jl. Dr. Soeparno No. 60, Kawang Bawang, Karangwangkal, Purwokerto, Banyumas, Central Java, Indonesia. 53122. email: katriandini[at]unsoed.ac.id. Mobile: +62 85229242224. (corresponding author) 2Postgraduate Programs, Sebelas Maret University Surakarta. Jl. Ir. Soetami No. 36, Kenting, Jebres, Surakarta, Central Java, Indonesia. Tel. (+62) 271-646994. Fax (+62) 271-636268. Abstract Background: Anemia is a medical condition that indicates the number of red blood cells is less than normal. Efforts to control anemia in pregnant women are done through supplementation of the Fe-folic acid and calcium program. Compliance pregnant women take supplements of Fe-folic acid and calcium to help improve the babys birth weight. The purpose of this study was to analyze the effect of compliance supplementation of Fe-folic acid and calcium to the levels of hemoglobin in third-trimester pregnant women and infant birth weight. Method: The subjects are the third-trimester pregnant women as much as 65 and then checked levels of hemoglobin and given supplements of Fe-folic acid and calcium for three months, in 2 weeks before the estimated birthday, hemoglobin levels were checked again then weighing the babys birth weight. Data were analyzed by the test for normality using the Fisher Test, bivariate analyzed then using Chi-Square and Fisher Test and linear regression for analyzed multivariate. Results: Compliance with consumption of Fe-folic acid supplements affected the level of maternal hemoglobin with an R2 of 0.60, which means that the effect of consumption of Folic acid on maternal hemoglobin levels was 6% while influenced by other variables. Conclusion: Compliance with consumption of Fe-folic acid and calcium supplements Aff hemoglobin levels of third-trimester pregnant women. However, the consumption of Fe-folic acid and calcium supplements did not have a significant effect on determining the birth weight of a baby. Keywords: Compliance; Fe-folic acid supplements; calcium; hemoglobin levels; birth weight Share Link | Plain Format | Corresponding Author (Katri Andini Surijati)

203	Pharmacy	ABS-293
An Online Health Promotion Program to Improve Knowledge, Attitude, and Behavior of Antibiotics Usage in Al Amin Islamic Boarding School Purwokerto Nia Kurnia Sholihat1*, Adhiyah Nuur Fitri2 1Assistant Professor, Department of Pharmacy, Universitas Jenderal Soedirman, Jl. Dr. Soeparno Kampus Karangwangkal, Purwokerto, Indonesia, email: nia.sholihat[at]unsoed.ac.id (corresponding author) 2Student, Department of Pharmacy, Universitas Jenderal Soedirman, Indonesia Abstract Background: Uncontrolled use of antibiotics can cause resistance, which could lead to other health problems. Therefore, a health promotion program is needed to increase the knowledge, attitudes, and behavior of the community towards the use of antibiotics. Purpose: This study aims to evaluate the impact of online health promotion on the knowledge, attitudes, and behavior of Al Amin Islamic boarding school students about antibiotics. Methods: This was a quasi-experimental study, using two groups, pretest-posttest. An online health promotion program was developed, including an educational video and e-booklet which were given at the beginning of the study, then followed by infographics and reminder messages once a week for three weeks. Knowledge, attitude, and behavior were assessed using a questionnaire before and after the intervention. Results: Thirty-five participants in the control group and thirty-one participants in the intervention group were enrolled in this study. An online health promotion program can increase knowledge, attitude, and behavior significantly in the intervention group (p-value=0.001). There was a significant difference between the intervention and control group (p-value=0.001). Conclusion: Providing online health promotion is effective in increasing students knowledge, attitudes, and behavior regarding antibiotics. Keywords: antibiotics, health promotion, student, pharmacist Share Link | Plain Format | Corresponding Author (Nia Kurnia Sholihat)

204	Pharmacy	ABS-42
Comparison of Estimated Glomerular Filtration Rate Equations for Dosing Antibiotics in Chronic Kidney Disease Patients Dewi Latifatul Ilma1*, Fita Rahmawati2, Djoko Wahyono3 1Lecturer, Department of Pharmacy, Jenderal Soedirman University, Indonesia 2Associate Professor, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia 3Professor, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia Email: dewilatifatulilma[at]unsoed.ac.id (corresponding author) Abstract Background: Antibiotics dose require dose adjustment according to renal function in chronic kidney disease patients. The optimal glomerular filtration rate (GFR) estimation equations remain uncertain to assess the individual patient s GFR as the degree of dose adjustment. Purpose: To determine the dose adjustment of antibiotics in patients with chronic kidney disease based on the estimation of glomerular filtration rate (eGFR) using the Cockroft Gault (CG), the Modification of Diet in Renal Disease formula (MDRD), and the Chronic Kidney Disease Epidemiology Collaborative (CKD EPI) equations. Methods: A cross-sectional study was conducted in chronic kidney disease patients who had used antibiotics when admitted to the hospitals during January-December 2017. The data were collected from the patients medical records in two hospitals in Yogyakarta and analyzed using the Kruskal Wallis test. In this study, 131 medical records were assessed. Results: The study found that no significant differences (Chi square=1.5968, df=2, p=0.45) among the calculation of eGFR using CG, MDRD, and CKD EPI equations. Antibiotics dose were unadjusted properly in 38.29% antibiotic using the CG equation, 38.51% antibiotic using the MDRD equation, and 38.07% antibiotic using the CKD EPI equation. The most frequently used antibiotic that needs dose adjustment was ceftazidime (16.53%). Conclusion: Although the three equations showed no significant differences to calculate eGFR using CG, MDRD, and CKD EPI, there is a slight difference in the percentage of unadjusted antibiotics dose. Keywords: eGFR, Cockroft-Gault, MDRD, CKD-EPI, Antibiotic Share Link | Plain Format | Corresponding Author (Dewi Latifatul Ilma)

205	Pharmacy	ABS-44
Development, Validation and Testing of Effectivity of Online Learning Questionnaire (KEPO) in Pharmacy Students of Public Universities in Central Java Province, Indonesia Laksmi Maharani(1), Nuraini Ekawati(2), Adi Yugatama(3)(*) (1) Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University, Indonesia (2) Department of Pharmacy, Medical Faculty, Diponegoro University, Indonesia (3) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Jl. Ir Sutami No. 36A, Jebres, Surakarta, Indonesia, Email: adiyugatama.apt[at]gmail.com (corresponding author) Abstract Background: COVID-19 pandemic causes changes in learning method of some univesities in Indonesia. Diponegoro University, Sebelas Maret University, and Jenderal Soedirman University were three public universities in Central Java which have pharmacy major and implementing online learning policy. Purpose: To develop a valid and reliable questionnaire for assessing effectivity of online learning in pharmacy students, and to determine the effectiveness and differences of online learning in pharmacy students of three public universities in Central Java. Methods: Development and validation of KEPO were consisting of identifying dimension, item development, preliminary pilot testing, then validation and reliability testing. The research on determining effectivity and differences was using descriptive analytic methods. KEPO was administered by Google form to pharmacy students in three public universities in Central Java Province. Data were analyzed descriptively to determine the effectivity score and category then tested using Kruskal Wallis test. Results: Final questionnaire consists of 14 items using Likert-style scores. All items were valid (r>0,321) and reliable (cronbach alpha 0,805) tested in 40 respondents as pilot testing. Average effectivity score of online learning in 478 pharmacy students of three public universities in Central Java was (37,88 +/- SD 4,9). There were no significant differences of online learning effectivity among pharmacy students in Diponegoro University, Sebelas Maret University, and Jenderal Soedirman University (p>0,05). Conclusion: KEPO is a valid and reliabel questionnaire used for assessing effectivity of online learning in pharmacy students. Keywords: online learning, effectivity questionnaire, KEPO, pharmacy students Share Link | Plain Format | Corresponding Author (Laksmi Maharani)

206	Pharmacy	ABS-311
Impact of home visit pharmacists on diabetes patient medication adherence and self-care activities: a randomized controlled trial Tunggul Adi Purwonugroho1*, Laksmi Maharani1, Ika Mustikaningtias1, Budi Raharjo2, Vitis Vini Fera Ratna Utami1, Githa Fungi Galistiani3, Hanif Nasiatul Baroroh1, Hening Pratiwi1 1Department of Pharmacy, Faculty of Health Sciences, University of Jenderal Soedirman, Purwokerto, Indonesia 2Indonesian Pharmacist Association, Central Java Region, Indonesia 3Faculty of Pharmacy, University of Muhammadiyah Purwokerto, Purwokerto, Indonesia Abstract Background: Pharmacist has a promising role to improve diabetes patient condition by providing an educational intervention. Purpose: This study aimed to evaluate the impact of home-visit pharmacist on diabetes patient^ medication adherence and self-care activities. Methods: Twenty four weeks of randomized controlled trial in Banyumas district, Central Java province, Indonesia was performed. Patients in the intervention group received home visit services by participant pharmacists, while the control group obtained usual care. The outcomes were patient medication compliance measured with Morisky Medication Adherence Scales-8 (MMAS-8) and patient lifestyle using The Summary of Diabetes Self-Care Activities (SDSCA) questionnaire. Before other statistical tests were taken, the data were tested for normality, and parametric or non-parametric tests were conducted accordingly. The level of significance used in all tests was 0.05 (two-tailed). Results: In the final analysis, 41 patients in the control group and 47 patients in the intervention group were included. Adherence score increased 13.11% (95%CI: 7.00% to 19.22%- P < 0.001) and 20.21% (95%CI: 13.56% to 26.86%- P < 0.001) on usual care group and intervention group, respectively. Moreover, there was 5.18% between-group improvement even though the change was not statistically significant (P = 0.210). There were significant improvements on SDSCA scores in intervention group (score increased by 7.32, p<0.0001) and control group (score increased by 5.05, p=0.015). Additionally, there was a between-group difference of 2.27 on SDSCA score, but the statistic was not significant (p=0.4). Conclusion: Even though statistically significance has not been achieved, home-visit performed by community pharmacist improved the adherence and lifestyles of patients with diabetes. Keywords: adherence, diabetes, home-visit pharmacist, self-care activities Share Link | Plain Format | Corresponding Author (Tunggul Adi Purwonugroho)

207	Pharmacy	ABS-327
Antibacterial activity of combination papaya leaf (Carica papaya L.) extract and betel leaf (Peper betle L.) against Escherichia coli Endah Fajar Kurniawati, Sunarto, Triyadi Hendra Wijaya Jenderal Soedirman University Abstract Background: Papaya leaves and betel leaves are used by the community as antiseptic agents. This study aims to evaluate antibacterial activity of combination activity of papaya leaf extract and betel leaf and to analyze secondary metabolites contained in both extracts. Method: Simplisia of pepaya leaves and betel leaves was extracted by using ethanol 96%. Research conducted by measuring the clear zone of extract used disc diffusion method. The Methode used was phytochemical (qualitative test) using test tube to determine type of the active compounds contained in the plant. Chemical tested in this study were Flavonoid, saponin, and tannin analyzed by colour test. Data analysis used the Kruskal-Wallis test. Results: The ethanol extract of papaya leaves at concentration 25% has an inhibition zone diameter in E. coli bacteria, which is 11 mm, while the ethanol extract of betel leaves at concentration 25% is 12.6 mm. The combination ratio of papaya leaf extract 1: 1, 1: 3, 3: 1 had inhibition zone diameter of 12.6 mm, 13.3 mm, 11 mm, respectively. Papaya and betel leaves contain flavonoids, saponins, and tannins. Conclusion: The volume ratio variation that had the highest inhibition in papaya leaf extract and betel leaf extract with a concentration of 25% for E. coli bacteria was found in a ratio of 1: 3 with an inhibition zone diameter of 13.3 mm. Keywords: Papaya leaf extract, betel leaf extract, Escherichia coli, antibacterial Share Link | Plain Format | Corresponding Author (Endah Fajar Kurniawati)

208	Pharmacy	ABS-79
Anti-inflammatory Effect of Zingiberaceae Herbals in Rats Heny Ekowati*, Fitria Nur Malita Sari, Bellia Hasyim, Esti Dyah Utami, Eka Prasasti Nur Rachmani, Laksmi Maharani, Ika Mustikaningtias Pharmacy Department, Faculty of Health Sciences, Universitas Jenderal Soedirman, Jl. Dr. Suparno, Karangwangkal, Purwokerto 53123, Indonesia Abstract Zingiberaceae family, have potential effect as anti-inflammatory agent. The purpose of this study was to determine the anti-inflammatory effects of C. longa (CL), A. galanga (AG), Z. officinale (ZO), Z. cassumunar (ZC), and their combination extract in rats. The hit-paw udema method was used to examine the anti-inflammatory effect of the herbs. An experimental study design was set up with post only control group design. Rats were divided into five groups, 5-7 rats in each group. Group I, the solvent control group was given Tween orally- group II is the positive control group was given Na-diclofenac 4.5 mg/kgBW. The other three groups were given CL, AG, ZO, ZC and its combination, at the dosage of 500 mg/kgBW for single extract and 250 mg/kgBW each for combination extract. CL and AG extract was dissolved in Tween 1% and administered orally 1 h before carrageenan injection (sub-plantar 1 mL in rat foot). Observations of anti-inflammatory effects was performed using udema volume (mL), the percentage of increasing volume, Area Under Curve (AUC), anti-inflammatory effect percentage (% DAI) and motility score. Data were analyzed using one-way ANOVA followed by LSD. The percentage of DAI showed that the anti-inflammatory activity in combination extract was significantly higher than single extract. In CL and AG extract : 60,03 %- 50,11 %- 51,09 %, respectively. In ZO and ZC : 36%, 31% and 20%, respectively. Motility score data showed that extract combination has higher anti-inflammatory effect than their single extract. The combination and their single extract, CL and AG:1,74- 1,55- 1,52- respectively- in ZO and ZC : 1.29- 1.29- 1,26, respectively. This study indicated that combination of Curcuma longa and Alpinia galanga- Zingiber officinale and Zingiber cassumunar, can be developed as anti-inflammatory agent. Keywords: Zingiberaceae, hit-paw udema method, rats Share Link | Plain Format | Corresponding Author (Heny Ekowati)

209	Pharmacy	ABS-83
PHYTHOCHEMICAL ANALISIS OF BRUGUIERA GYMNORHIZA STEM BARK AS ANTIOXIDANT AND APHA-GLYCOSIDASE INHIBITORS Warsinah(a*), Hartiwi Diasturi(b) Faculty of Health and Sciences Jenderal Soedirman University Abstract Gymnorhizza bruguiera is a mangrove plant used for traditional medicine. This plant contains alkaloid compounds, plavanoids, saponins, tannins and steroids. It has potential activity as a source of antioxidants and 945;-glucosidase inhibitors. Antioxidants are substrate oxidation inhibitors that are easily oxidized, whereas 945;-glucosidase inhibitors can limit the action of 945;-glucosidase that digest carbohydrates in the intestine. This study aims to determine the class of active compounds that function as antioxidants and 945;-glucosidase enzymes in vitro in Bruguiera gymnorhiza stem bark extract. This research includes extraction using n-hexane, ethyl acetate and methanol solvent, phytochemical tests with TLC method, antioxidant activity test with DPPH method, 945;-glycosidase inhibitor activity and active extracts are fractionated with preparative TLC, then active fractions are identified by GCMS.The results showed that the yield of n-hexane extract was 0.90%, ethyl acetate extract was 4.27% and methanol bark extract was 12.65%. Ethyl acetate and methanol extracts are a group of compounds that provide very strong antioxidant activity while n-Hexane extract is very weak. Ethyl acetate and methanol extracts provide inhibitory activity of 66.03% and 68.80%, at a concentration of 250 ppm while at glucobay 5 at 90.89%. Thin layer chromatography analysis produced the best eluent, methanol: DCM: n-hexane (2: 3: 1) and showed 5 fractions. Fraction 1 has 945;-glucosidase inhibiting activity with an IC50 value of 167.5 ppm. In fraction 1 hexadecanoic acid and phenol, 2,2 methylenebis were identified. Ethanol extract has the highest antioxidant activity and 945;-glucosidase inhibitors and the extract contains hexadecanoic acid and phenol, 2.2 methylenebis. Keywords: B gymnorhiza; active compounds; inhibitors; antioxidants; α-glucosidase. Mangrove; stem bark Share Link | Plain Format | Corresponding Author (Warsinah Warsinah)

210	Pharmacy	ABS-91
THE CORRELATION BETWEEN ADMINISTRATION DIGOXIN DOSAGE AND BLOOD DRUG LEVELS IN HEART FAILURE PATIENTS AT RSUD PROF.DR. MARGONO SOEKARDJO PURWOKERTO Masita Wulandari Suryoputri*, Laksmi Maharani, Ika Mustikaningtias Departement of pharmacy, Faculty of Health Sciences, Jenderal Soedirman University. *masitawulandarisuryoputri[at]gmail.com Abstract Drug dosage is one of the main factors that determine the accomplishment of a therapy. If the clinical outcome is achieved, the therapy to be said successful. Outcome clinic is achieved if blood drug levels are within the therapeutic range. This study aims to determine the correlation of digoxin dose administration to the estimation of blood drug levels in heart failure patients. This study uses an observational design. Sampling with a total sampling method. Data on dosage and frequency of drug administration from patients medical record data, pharmacokinetic estimation of drug levels in the blood is calculated. Data to find out whether or not there is a correlation between dosing and estimation of blood drug levels using a contingency coefficient correlation test with an interpretation of p < 0.05. Subjects were inpatient heart failure patients who received oral digoxin therapy during June-August 2019. The results of this study showed that the estimated levels of digoxin in the blood (Css) digoxin were appropriate therapeutic range of 0.50 - 0.90 ng/ml 4 patients (13.33%) and those that did not fit the therapeutic range > 1.00 ng/ml were 26 patients (86.67%). The results of the analysis of the contingency coefficient correlation test showed that p-value 0.009 (p < 0.05) which means there is a relationship between the administration of digoxin dosage to the estimation of blood drug levels in patients with heart failure in RSUD Prof. Dr. Margono Soekardjo Purwokerto. Keywords: Digoxin;Dosage;Heart Failure Share Link | Plain Format | Corresponding Author (Masita Wulandari Suryoputri)

Page 7 (data 181 to 210 of 283) | Displayed ini 30 data/page
<< PREV 1 2 3 4 5 6 7 8 9 10 NEXT >>

Powered By Konfrenzi Ultimate 1.832L-Build7 © 2007-2026 All Rights Reserved