THE CORRELATION BETWEEN ADMINISTRATION DIGOXIN DOSAGE AND BLOOD DRUG LEVELS IN HEART FAILURE PATIENTS AT RSUD PROF.DR. MARGONO SOEKARDJO PURWOKERTO Masita Wulandari Suryoputri*, Laksmi Maharani, Ika Mustikaningtias
Departement of pharmacy, Faculty of Health Sciences, Jenderal Soedirman University.
*masitawulandarisuryoputri[at]gmail.com
Abstract
Drug dosage is one of the main factors that determine the accomplishment of a therapy. If the clinical outcome is achieved, the therapy to be said successful. Outcome clinic is achieved if blood drug levels are within the therapeutic range. This study aims to determine the correlation of digoxin dose administration to the estimation of blood drug levels in heart failure patients. This study uses an observational design. Sampling with a total sampling method. Data on dosage and frequency of drug administration from patients medical record data, pharmacokinetic estimation of drug levels in the blood is calculated. Data to find out whether or not there is a correlation between dosing and estimation of blood drug levels using a contingency coefficient correlation test with an interpretation of p < 0.05. Subjects were inpatient heart failure patients who received oral digoxin therapy during June-August 2019. The results of this study showed that the estimated levels of digoxin in the blood (Css) digoxin were appropriate therapeutic range of 0.50 - 0.90 ng/ml 4 patients (13.33%) and those that did not fit the therapeutic range > 1.00 ng/ml were 26 patients (86.67%). The results of the analysis of the contingency coefficient correlation test showed that p-value 0.009 (p < 0.05) which means there is a relationship between the administration of digoxin dosage to the estimation of blood drug levels in patients with heart failure in RSUD Prof. Dr. Margono Soekardjo Purwokerto.
