Iron Supplementation Improves Ferritin and Zinc Blood Levels (In Vivo Study) Hesti Permata Sari (a*), Farida (a), Afina Rachma Sulistyaning (a), Ibnu Zaki (a)
a) Nutrition Study Program, Faculty of Health Sciences, Universitas Jenderal Soedirman
Jalan Dr. Soeparno, Karangwangkal, Purwokerto
* hesti.sari[at]unsoed.ac.id
Abstract
Background.Iron deficiency anemia is a major nutritional problem in Indonesia. Prevalence of iron deficiency anemia is found in adolescent girls which is equal to 48.9%. One of the available effort to alleviate this condition is iron supplementation. However, inconsistency reports regarding iron supplementation effect towards other micro mineral such as zinc still persist.Studies show that daily iron supplementation in 284 Indonesian infants lowers serum zinc levels after supplementation. Another opposite study is that iron supplementation of 50 mg increases serum zinc levels.Objective. This study aims to determine various doses of TTD supplementation effect on ferritin and zinc levels in anemic Sprague Dawley rats. Methods. True experimental was used as a research design with pre-post test control group design. 30 female Sprague Dawley white rats used in this study were divided into 5 groups, which are K+, K-, P1, P2, and P3, followed by various doses of iron supplementation for 14 days with standard feed AD II comfeed. The data were analyzed using one way anova test followed by LSD post hoc test. Results. The results showed a significant difference in ferritin and zinc levels in each group after receiving iron supplementation. The highest increase of ferritin and zinc blood levels occurred in P3 group(2.16mg of iron supplementation dosage) with the difference3,4 ng/ml and 0,64 mg/L of ferritin and zinc blood levels respectively. Conclusion. In conclusion, the administration of iron supplementation can increase both ferritin and zinc blood levels in anemic rats, although the numberdepends on the dosage and duration of TTD supplementation.
Keywords: Ferritin serum; Zinc; Iron supplementation; Anemic rats
