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61	Nutrition Science and Functional Food Development	ABS-34
Sensory Acceptability, Antioxidant Activities, and Total Phenolic of Kombucha from Tayu Green Tea sutyawan1*, novidiyanto1 1Department of Nutrition, Polytechnic Ministry of Health Pangkalpinang, Indonesia Abstract Background: Kombucha is a fermented tea beverage with health benefits due to its antioxidant, antidiabetic, and antibacterial properties. Kombucha can be made from various types of tea. Green tea from tayu leaves is a local specialty originating from Ketap Village, West Bangka Regency. Previous research has shown that kombucha from tayu black tea has a higher antioxidant content than commercial tea. Purpose: The purpose of this study was to to compare the sensory acceptability, antioxidant activity, and total phenols of kombucha made from tayu green tea with commercial tea. Methods: The research design used was purely experimental in the field of food production. The sensory characteristics were determined through organoleptic testing involving 30 semi-trained panelists. Total phenolics were tested using the Folin-Ciocalteu method and antioxidant activity using the FRAP (Ferric Reducing Antioxidant Power) method. Statistical analysis were conducted using independent sample t-test test. Results: The results showed that the acceptability of kombucha from tayu green tea was significantly higher (p<0.05) in all aspects (color, aroma, and taste) than commercial tea. The antioxidant activity of kombucha from tayu green tea was higher than that of commercial tea, but not significantly different (p>0.05). The total phenol content was the same for both types of kombucha. Conclusion: The acceptability and antioxidant activity of green kombucha made from tayu green tea are higher than those of kombucha made from commercial tea. Research recommends examining the effect of fermentation duration and sugar concentration on the antioxidant activity, polyphenols, and acceptability of Tayu tea leaf kombucha. Keywords: antioxidant activity, kombucha, tayu green tea leaves Share Link | Plain Format | Corresponding Author (Sutyawan Sutyawan)

62	Nutrition Science and Functional Food Development	ABS-37
SPROUTED Glycine max L. YOGHURT WITH TURMERIC AND AROMATIC GINGER RICH IN ANTIOXIDANTS: A DYSLIPIDEMIC FUNCTIONAL DRINK Hery Winarsi1*, Friska Citra Agustia1, Annisa Indriyani1 1Department of Nutrition, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, 53123, Central Java, Indonesia *Corresponding author: winarsi12[at]gmail.com Abstract Background: Dyslipidemia increases free radicals that trigger oxidative stress, but antioxidant-rich foods can suppress it. Purpose: This study aimed to develop a formula for sprouted Glycine max L. (edamame bean) yoghurt with turmeric and aromatic ginger (Yo-Glytagin), rich in phenolic antioxidants and crude fiber. Methods: A factorial randomized block design was employed with three factors: 1st Factor- proportion of sprouted edamame milk to skim milk (P1=90:10, P2=80:20, P3=70:30)- 2nd Factor-lactic acid bacteria (LAB) concentration (B1= 0.3%, B2= 0.5%)- and 3rd Factor-concentration of turmeric and aromatic ginger extract (A1=5%, A2=10%), with three replications. The sprouted edamame milk, skim milk, turmeric-aromatic ginger extract, and 5% sucrose were mixed and heated to boiling. The mixture was cooled to 40-45^C, then inoculated with the LAB starter. The mixture was incubated at room temperature (27-35^C) for 24 hours to produce Yo-Glytagin, which was then stored in a refrigerator. Total phenolic content was determined using the Folin-Ciocalteu method, and crude fiber was measured using the SNI 01-2891-1992 method. Data were analyzed using ANOVA, followed by DMRT at a significance level of &#945-=0.05, if applicable. The best formula was determined using an effectiveness index (De Garmo et al., 1984). Results: The best Yo-Glytagin formula consisted of 80 parts sprouted edamame milk and 20 parts skim milk, with 10% turmeric-aromatic ginger and 0.5% LAB. This formula yielded a phenolic antioxidant content of 5,459.56 mg GAE/100g and crude fiber of 2.07%. Conclusion: This Yo-Glytagin rich in antioxidant, holds potential health benefits for individuals with dyslipidemia. Keywords: Yo-Glytagin, antioxidant, phenolic, fiber, dyslipidemia Share Link | Plain Format | Corresponding Author (Hery Winarsi)

63	Nutrition Science and Functional Food Development	ABS-39
Enhancement the Functional Characteristics of Jack Bean (Canavalia ensiformis (L.) D.C.) Sprouts by Tempeh Fermentation in Different Packaging Type Friska Citra Agustia12*, Aprilia Fitriani3 1Department of Nutrition Science, Faculty of Health Sciences, Universitas Jenderal Soedirman, Purwokerto, Indonesia. 2Research Centre of Rural Health, Institute for Research and Community Service, Universitas Jenderal Soedirman, Purwokerto, Indonesia. 3Food Technology Department, Faculty of Industrial Technology, Universitas Ahmad Dahlan, Yogyakarta, Indonesia. Abstract Background: Degenerative diseases constitute a worldwide health issue that requires urgent attention. Diabetes mellitus is a type of degenerative disease that poses a global health challenge. The prevention of diabetes mellitus can be achieved by consuming meals rich in resistant starch and fiber. Tempeh is one example of a food that contains significant amounts of both. Tempeh can be manufactured from several varieties of legumes and peas. The production of tempeh employs the action of Rhizopus sp. during the fermentation process. The quality of the manufactured tempeh is affected by the raw materials and packaging employed. Variations in packing will influence the fermentation conditions accessible for Rhizopus sp. Purpose: This study seeks to assess the variations in packaging styles on the starch and dietary fiber compositions of tempeh derived from jack bean sprouts. Methods: This research experimental methods with one factor included three distinct types of packaging: teak leaves, banana leaves, and plastic packaging. the fermentation time is 48 h. The data were analyzed using analysis of variance. The average difference between treatments was analyzed using Tukey^s test, and statistical significance was considered at P<0.05. Results: The results indicated that tempeh in plastic packaging contained the highest total starch (54.54%), but tempeh wrapped in banana leaves exhibited the most resistant starch concentration (14.54%). Conversely, tempeh encased in teak leaves possesses the highest nutritional fiber level (28.1%), in comparison to tempeh wrapped in other materials. Conclusion: Tempe bean sprouts packaged in teak and banana leaves exhibited reduced levels of amylose and amylopectin relative to those packaged in plastic. Nonetheless, tempe packaged in banana leaves exhibited elevated levels of resistant starch, while teak leaf packing resulted in increased total dietary fiber. Keywords: tempeh, resistance starch, dietary fiber, packaging type, germinated jack bean Share Link | Plain Format | Corresponding Author (Friska citra Agustia)

64	Nutrition Science and Functional Food Development	ABS-62
Child and Family Factors as Predictors of Nutritional Status in Elementary School Students Wahyu Vera Wardani (a*), Dyah Umiyarni Purnamasari (b), Atikah Proverawati (c) Universitas Jenderal Soedirman Abstract The nutritional status of elementary school students is influenced by various child and family factors. This study aimed to analyze predictors of nutritional status among school-aged students in Kedungbanteng District, Banyumas Regency. This study was conducted on 95 students in grades 4 and 5 (aged 9-12 years) from two elementary schools. The collected data comprised child characteristics (age, sex, nutritional status) and parental characteristics (education, occupation, and household income). Anthropometric measurements were taken using a digital weighing scale and microtoise. Nutritional status was determined based on Body Mass Index-for-Age (BMI/A) using Z-scores. Data were analyzed using multiple dummy variable regression with the backward method. The results showed that age, sex, and household income were significant predictors of students^ nutritional status. Age was positively associated with BMI/A, indicating that older students tended to have better nutritional status. Sex had a negative effect, with girls more likely to have lower BMI/A compared to boys. Household income showed a positive association, with students from higher-income families more likely to achieve adequate nutritional intake. In contrast, parental education and occupation were not significant predictors in the final model. This study emphasizes the importance of considering sociodemographic factors, particularly household income, in designing nutritional intervention programs for elementary school students. Keywords: Nutritional status- Elementary school students- Age- Sex- Household income Share Link | Plain Format | Corresponding Author (Wahyu Vera Wardani)

65	Nutrition Science and Functional Food Development	ABS-74
Nutritional Indicators and Cognitive Impairment among Community-Dwelling Older Adults in Indonesia: Evidence from the Indonesia Longitudinal Aging Survey (ILAS) Lala Sri Fadila (a*), Ernis Asanti (a) a) Department of Nutrition Science, Universitas Jenderal Soedirman Jl. DR. Soeparno No.60, Kec. Purwokerto Utara, Kabupaten Banyumas, Jawa Tengah 53122, Indonesia *lala.sri[at]unsoed.ac.id Abstract Background: Nutritional indicators, including body mass index (BMI) and sarcopenia risk are important determinants of cognitive function in older adults. While the relationship between BMI and cognitive impairment has shown mixed findings, sarcopenia consistently demonstrates a strong association with cognitive decline. Despite its significance, research on sarcopenia^s impact on cognitive function in low- and middle-income countries remains limited. Given the aging population, understanding nutritional indicators^ role in cognitive health is needed to inform public health strategies for aging populations. Purpose: This study aimed to examine the association between nutritional indicators, including obesity and sarcopenia risk, and cognitive impairment among community-dwelling older adults in Indonesia using data from the Indonesia Longitudinal Aging Survey (ILAS). Methods: We conducted a cross-sectional analysis of ILAS participants aged &#8805-60 years. We used data from 1495 older adults who had completed a survey on sociodemographic information, including sex, age, educational status, and health factors such as nutritional status, sarcopenia risk, waist circumference, depression risk, smoking behaviour, and illness. Cognitive function was assessed using the Six-Item Screener (SIS) and categorized using cutoffs for Asians. Logistic regression analysis was conducted to identify the association of nutritional status and cognitive impairment among older adults. Results: The prevalence of cognitive impairment in the study population was 35.65%. This study indicates that older adults with obesity are significantly associated with a lower risk of cognitive impairment. In contrast, those with a sarcopenia risk were more likely to be cognitively impaired. Conclusion: The findings showed that obesity was associated with a lower risk of cognitive impairment among community-dwelling older Indonesian adults, while those with sarcopenia risk indicate otherwise. Future longitudinal studies incorporating dietary quality, body composition, and biomarkers are needed to better understand the mechanisms underlying this relationship and to guide tailored nutritional strategies for healthy aging. Keywords: Body Mass Index, Sarcopenia, Cognitive Impairment, Older Adults, Indonesia Share Link | Plain Format | Corresponding Author (Lala Sri Fadila)

66	Nutrition Science and Functional Food Development	ABS-93
HEME AND NON-HEME IRON INTAKE WITH THE INCIDENC OF IRON DEFICIENCY ANEMIA IN ADOLESCENT GIRLS Izka Sofiyya Wahyurin (1), Lina Nimatul Maula (1), Hiya Alfi Rahmah (1) (1) Department of Nutrition Science, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia Abstract Adolescents are a population group vulnerable to anemia, with the prevalence in Indonesia reaching 18.4% in 2018. Among adolescent girls, anemia may impair growth, reduce productivity, and increase long-term risks during pregnancy and childbirth. Iron deficiency anemia in this group can be influenced by factors such as dietary iron intake and menstruation. This study aimed to examine the association between heme and non-heme iron intake and the incidence of iron deficiency anemia among adolescent girls at SMA Negeri 1 Purwokerto. An observational analytic study with a cross-sectional design was conducted on 81 tenth-grade students selected through purposive sampling. Data on heme and non-heme iron intake were collected using a semi-quantitative food frequency questionnaire (SQ-FFQ), while anemia status was determined with a Sejoy digital hemoglobinometer. The Chi-Square test was applied to analyze associations. The findings showed that 50.6% of respondents had inadequate heme and non-heme iron intake, and 22% were classified as anemic. However, no significant association was found between heme iron intake and anemia incidence (p = 0.635) or between non-heme iron intake and anemia incidence (p = 0.953) Keywords: adolescent- anemia- heme- iron- non-heme Share Link | Plain Format | Corresponding Author (Izka Sofiyya Wahyurin)

67	Nutrition Science and Functional Food Development	ABS-97
Differences in Energy and Protein Adequacy Levels in Children and Maternal Diet Quality Between Stunting and Non-Stunting Children Aged 6 - 23 Months in Banyumas Regency Khadhra Numanya, Teguh Jati Prasetyo, Sifa Aulia Wicaksari Nutrition Science, Jenderal Soedirman University, Jalan Prof. Dr. HR Boeyamin, Banyumas 53122, Indonesia Abstract Background: Stunting is a one of the common nutrition problems encountered during the first 1000 days of life, which hinders child growth and development. It may result from direct factors such as nutrition intake, as well as indirect factors such as maternal diet quality that can affect breast milk composition. This study aims to determine the differences in energy and protein adequacy levels in children and maternal diet quality in stunting and non-stunting children aged 6 - 23 months in Banyumas Regency. Methods: This case-control study involved 36 samples in each group of stunting and non-stunting children aged 6 - 23 months in Sumbang, Banteran, and Karangtengah Villages. Respondents were selected through purposive sampling with age (+2 months) and village matching. Dietary intake was assessed using the SQ-FFQ and maternal diet quality using the HEI-2015. Bivariate analysis was performed using the Independent t-test and Mann-Whitney test. Result: The result showed significant differences in the energy and protein adequacy levels between stunting and non-stunting children aged 6 - 23 months in Banyumas Regency (p-value <0,001) with higher energy and protein adequacy levels in the non-stunting group. However, there was no significant difference in the diet quality of mothers with stunting and non-stunting children aged 6 - 23 months in Banyumas Regency (p-value = 0,254). Conclusion: There were significant differences in the energy and protein adequacy levels in children, but no significant difference in the maternal diet quality between stunting and non-stunting children aged 6 - 23 months in Banyumas Regency. Keywords: energy adequacy, diet quality, protein adequacy, stunting Share Link | Plain Format | Corresponding Author (Khadhra Numanya)

68	Nutrition Science and Functional Food Development	ABS-98
INFLUENCE OF NUTRITION EDUCATION USING FOOD REMINDER CARD MEDIA ON KNOWLEDGE, ATTITUDE, AND PRACTICE OF PORTIONING FOOD ACCORDING TO ISI PIRINGKU GUIDELINES (Study on Adolescents At SMA Negeri 2 Purwokerto) Putri Isrotul Faizah (a*), Hiya Alfi Rahmah (b), Izka Sofiyya Wahyurin (c) Jenderal Soedirman University Abstract Background: The prevalence of overweight among adolescents in Indonesia, especially in Banyumas Regency was quite high at 5,73% and has the potential to increase the risk of non communicable diseases. Nutritional knowledge is one of the factors in the formation of attitudes and behaviors in choosing food. This study aims to determine the effect of nutrition education using food reminder card media on knowledge, attitudes, and practices of portioning food according to the contents of isi piringku at SMAN 2 Purwokerto. Methodology: This study used a quasi-experimental one group pretest-posttest design with 43 respondents. Respondents were taken by purposive sampling method. Education was provided using food reminder card media for 7 days. The instruments used were knowledge and attitude questionnaire of isi piringku contents, food checklist form of isi piringku contents, and 3x24 hour food picture. Data were tested using the Wilcoxon test. Results: There was an effect of Food Reminder Card media on knowledge (p=0.003). There was no effect of Food Reminder Card media on attitudes (p=0.060) and the practice of portioning food according to the contents of isi piringku (p=0,266). Conclusion: There was an effect of Food Reminder Card media on the knowledge of the contents of isi piringku in adolescents at SMA Negeri 2 Purwokerto. However, there was no effect of Food Reminder Card media on attitudes and practices of portioning food according to the contents of isi piringku for adolescents at SMA Negeri 2 Purwokerto. Keywords: Food Reminder Card, Isi Piringku, Knowledge, Food Portioning Practices, Adolescent, Attitude Share Link | Plain Format | Corresponding Author (Putri Isrotul Faizah)

69	Nutrition Science and Functional Food Development	ABS-99
FORMULATION OF ENTERAL FOOD BASED ON SOY FLOUR, PUMPKIN, AND BANANA AS AN ALTERNATIVE SNACK FOR STROKE PATIENTS Samia Sahal Bawazir, Hiya Alfi Rahmah, Izzati Nur Khoiriani Jenderal Soedirman University Abstract Background : Stroke is a pathological condition that can cause dysphagia or difficulty swallowing. Dysphagia can reduce the ability to consume food so that it can result in malnutrition, so enteral is needed to help meet the nutritional intake of stroke patients. This study aims to determine the effect of the proportion of soy flour, pumpkin, and banana on viscosity, hedonic, hedonic quality, best formula, and best formula proximate. Methods : This study used a Completely Randomized Design (CRD) method with 3 proportions of enteral formula, with a ratio of soy flour: pumpkin flour: banana flour P1 (9: 7: 5), P2 (5: 9: 7), and P3 (7: 5: 9). Several analyzes were conducted, namely viscosity test with Brookefield NDJ-8S Viscometer, hedonic organoleptic test and hedonic quality on 59 panelists, and proximate test on the best enteral formula. Result : The proportions of enteral formulas that included soy flour, pumpkin flour, and banana flour had a significant impact on various sensory attributes. These included hedonic color (p=0.000), aroma (p=0.014), texture (p=0.000), overall appearance (p=0.000), color quality (p=0.000), aroma quality (p=0.004), texture quality (p=0.000), and overall appearance quality (p=0.000). However, there were no significant effects observed on viscosity (p=0.235), taste (p=0.883), and taste quality (p=0.353). The best enteral formula was formula P2 with a ratio of soy flour: pumpkin: banana of 5:9:7 with an energy content of 347.4 kcal, 30 g protein, 3 g fat, 50.2 g carbohydrate, 16 g water, and 0.9 g ash. Conclusion : Powdered enteral formula based on soy flour, pumpkin, and banana has met the viscosity requirements and has good acceptability. Keywords: Enteral, Soybean Flour, Pumpkin Flour, Banana Flour, Stroke Share Link | Plain Format | Corresponding Author (Samia Sahal Bawazir)

70	Nutrition Science and Functional Food Development	ABS-102
RELATIONSHIP BETWEEN PROTEIN ADEQUACY LEVELS AND EXCLUSIVE BREASTFEEDING HISTORY WITH THE INCIDENCE OF STUNTING IN TODDLERS (Study in Sumbang Village, Sumbang District, Banyumas Regency) Destasya Fitri Olivia (a*), Teguh Jati Prasetyo (b), Hiya Alfi Rahmah (c), Izzati Nur Khoiriani (d), Katri Andini Surijati (e) a) Faculty of Health Science, Jenderal Soedirman University Jl. Prof. Dr. HR. Boenyamin No. 708, Purwokerto, Kabupaten Banyumas, Jawa Tengah, 53122 *oliviadestasya[at]gmail.com b) Faculty of Health Science, Jenderal Soedirman University c) Faculty of Health Science, Jenderal Soedirman University d) Faculty of Health Science, Jenderal Soedirman University e) Faculty of Health Science, Jenderal Soedirman University Abstract Sumbang Village in Sumbang Subdistrict is designated as one of the villages prone to stunting in Banyumas Regency with a prevalence of 14.4%. Factors contributing to stunting in toddlers include protein adequacy and exclusive breastfeeding. The study was designed to investigate the relationship between protein adequacy, exclusive breastfeeding history, and stunting in toddlers aged 24 to 59 months in the village. The study used a case control design with a sample of 37 stunted infants and 37 nonstunted infants in Sumbang Village. Respondents were selected using cluster sampling with matching based on age (plus or minus 2 months) and posyandu (integrated health service post) area. Data collection used the SQ FFQ questionnaire and the SKI exclusive breastfeeding history questionnaire. Bivariate analysis was conducted using a 2x2 Chi square test with IBM SPSS version 25. The results of bivariate analysis of protein adequacy was significantly associated with stunting in children aged 24 to 59 months (with a p value of 0.000 and an odds ratio of 6.781 with a 95% confidence interval of 2.1 to 20.1), whereas a history of exclusive breastfeeding showed no significant association with stunting in children aged 24 to 59 months (with a p value of 0.163). There is a significant association between protein adequacy levels and stunting in children aged 24 to 59 months. Children with inadequate protein adequacy levels are 6.781 times more likely to experience stunting than children with adequate protein adequacy levels. Keywords: Adequacy level of Protein, Exclusive breastfeeding, Toddler, Stunting, Sumbang Share Link | Plain Format | Corresponding Author (Destasya Fitri Olivia)

71	Nutrition Science and Functional Food Development	ABS-110
Resistant Starch Content of Rice with Low Temperature Storage Method Dwi Eva Nirmagustina1, Chandra Utami Wirawati1 1Politeknik Negeri Lampung Abstract Background: Rice (Oryza sativa L.) is a staple food of almost all Indonesian society. The main component of rice is starch. The number of people with diabetes mellitus in Indonesia is increasing every year, with 11,3% prevalence in 2024. Resistant starch is the fraction of starch that cannot be digested by the small intestine so that it can control blood sugar levels. One of the food processing processes putatively able to increase resistant starch is physical treatment, i.e., storage at low temperatures. The aim of the study was to determine the resistant starch content of 3 rice varieties with different amylose levels on low-temperature storage. Methods: The applied study design was Complete Group Randomized Design with 3 replications. The first factor is the type of rice with 3 levels, i.e. Cinta Manis, Mancul, and Mentik Susu. The second factor is low temperature storage with 4 levels, i.e. 5^C, 24 hours- 5^C, 48 hours- -20^C, 24 hours, -20^C, 48 hours. The acquired data were processed with variety imprints to find out the influence of treatment on the tested parameters. When there was a real influence then to know the difference between such treatments DMRT test (Duncan Multiple Range Test) was performed. Results: The results of the study showed that low-temperature storage had an effect on the resistant starch content of the 3 rice varieties. Low-temperature storage increases rice resistant starch. Each type of rice has different low-temperature storage in increasing resistant starch. The resistant starch content of sweet Love rice increased from 2.87% to 5.91% at 5^C, 48 hours, Emerging rice increased from 3.07% to 7.67%, Milk Growing rice increased from 2.27 to 8.17%. Conclusion: Storage of rice at low temperature will increase the resistant starch of rice with low amylose content the highest compared to rice with high amylose content. Keywords: rice, resistant starch, low temprature Share Link | Plain Format | Corresponding Author (Dwi Eva Nirmagustina)

72	Nutrition Science and Functional Food Development	ABS-119
EFFECTIVENESS OF GIVING A COMBINATION JUICE OF CUCUMBER (Cucumis sativus) GREEN MELON (Cucumis melo L.) WITH ADDITION OF HONEY ON REDUCTION OF ANAEROBIC EXERCISE ACID LAKTAT RATE (In vivo Study)ple Abstract Yoland Anugrahing Illah, Afina Rachma Sulistyaning, Teguh Jati Prasetyoo Submit This Sample Abstract Universitas Jenderal Soedirman Abstract Lactic acid is a byproduct of anaerobic metabolism that builds up after anaerobic physical activity. Cucumber and green melon contain potassium and citrulline, compounds that help accelerate the decrease in lactic acid levels. This study aims to determine and compare the effectiveness of giving a combination of cucumber, green melon, and honey juice on reducing lactic acid after anaerobic activity in Sprague dawley rats. The study used a true experimental design with a pretest and posttest with control group design. A total of 30 male rats aged 6 to 8 weeks were divided into five groups namely K negative without intervention and K positive only 1 minute swimming and M1 1 minute swimming and 30:70 dose and M2 swimming and 70:30 dose and M3 1 minute swimming and 50:50 dose. Lactic acid was measured from the tail vein using lactate meter. Data were tested using Shapiro Wilk and differences between groups were analyzed using one way ANOVA followed by Post Hoc LSD test. : Mean lactic acid at baseline was 34.17 mg per dL, increasing after swimming to 65.33 mg per dL is (K positive), 69.67 mg per dL (M1), 64.67 mg per dL (M2), and 66.67 mg per dL (M3). After juice administration, the levels decreased to 29.67 mg per dL (M1), 24.67 mg per dL (M2), and 37.33 mg per dL (M3). The dose that best reduced lactic acid levels after anaerobic activity was treatment M1 with a dose of 30:70 Keywords: Anaerobic, Lactic Acid, Muscle Fatigue, Cucumber, Green Melon. Share Link | Plain Format | Corresponding Author (Yoland Anugrahing Illah)

73	Nutrition Science and Functional Food Development	ABS-130
Risk Factor of Metabolic Syndrome among Canteen Food Handlers in Universitas Jenderal Soedirman Sifa Aulia Wicaksari, Afina Rachma Sulistyaning, Izka Sofiyya Wahyurin, Angelita Syahsiah Sasikirana, Stephani Monica Putri Department of Nutrition Science, Faculty of Health Sciences, Universitas Jenderal Soedirman Abstract Background: Metabolic syndrome is a cluster of interrelated risk factors, including abdominal obesity, dyslipidemia, hypertension, and impaired glucose regulation, which significantly increase the risk of cardiovascular disease and type 2 diabetes. Food handlers in canteen settings often face unique occupational and lifestyle challenges that may predispose them to metabolic syndrome. Objectives: This study aimed to analyze the risk factors associated with metabolic syndrome among canteen food handlers in Universitas Jenderal Soedirman. Methods: The study design is cross sectional study which was conducted in Universitas Jenderal Soedirman, Central Java, Indonesia during January - April 2024. The subjects were enrolled using purposive sampling which met the inclusion criteria: aged 18-59 years old, work in the canteen in the area of Universitas Jenderal Soedirman. The anthropometric measurements consist of body composition using bioelectrical impedance analysis and body mass index by measuring weight and height. Other variables were biochemical (blood glucose level, total cholesterol, uric acid), blood pressure, and dietary intake. Results: Total subjects were 56 food handlers which were dominated by female (85.7%), aged 30-59 years old (91.1%), employee (62.5), and had vigorous activity level (51.8%). Most of food handlers were overweight-obese (82.2%), central obesity (60.7%), and overfat (76.8%). The prevalence of metabolic syndromes among food handlers were 62.5% had hyperuricemia, 25% had hypertension, 17.9% had hypercholesterolemia, and 5.4% had hyperglycemia. Conclusions: The high prevalence of metabolic syndrome among food handlers at Universitas Jenderal Soedirman is concerning, highlighting the need for nutrition education to promote healthier eating habits, especially as they are exposed to food preparation throughout the day. Keywords: metabolic syndrome, food handler, canteen, obesity, adult Share Link | Plain Format | Corresponding Author (Sifa Aulia Wicaksari)

74	Nutrition Science and Functional Food Development	ABS-138
MODIFICATION OF ENTERAL BLENDERIZED FORMULA WITH TEMPE AND RED DRAGON FRUIT (Hylocereus polyrhizus) FOR DIABETES MELLITUS PATIENTS Celine Jessica Daniels, Yovita Puri Subardjo, Izzati Nur Khoiriani Jenderal Soedirman University, Faculty of Health Sciences, Nutrition Department, Jl. Profesor DR. HR Boenyamin No.708, Dukuhbandong, Grendeng, Kec. Purwokerto Utara, Kabupaten Banyumas, Jawa Tengah 53122 Abstract Background: Diabetes mellitus is highly prevalent in Indonesia, especially among the elderly with chewing and swallowing difficulties. This study offers an alternative enteral formula using local ingredients, tempeh and red dragon fruit, by modifying the DM formula used at RSUD Banyumas. Methods: A true experimental design was conducted using a Completely Randomized Design (CRD) with one factor: the proportion of tempe and red dragon fruit, tested in three formulation ratios. Viscosity was analyzed using Welch ANOVA with 95% confidence, followed by GamesHowell for significant results. Organoleptic data were tested with Friedman, and significant outcomes were followed by Wilcoxon tests (5% significance level). Results: The formulation proportion of tempeh and red dragon fruit had a significant effect (p<0.05) on all organoleptic parameters (hedonic and hedonic quality tests). The formulation also had a significant effect (p<0.05) on viscosity that measured using a viscometer and feeding tube (NGT Fr 18). Conclusions: The formulation proportion of tempeh and red dragon fruit had a significant effect on organoleptic and viscosity, which was measured using a viscometer and NGT Fr 18 feeding tube. The best formula is sample F3, with a viscosity of 401.5 cP, classified as honey-like according to the National Dysphagia Diet, and can be used for oral (ONS) or tube feeding. This formula provides 1.2 kcal/ml of energy, with 15% protein, 32.25% fat, 51.76% carbohydrates, and 1.06% fiber. One serving size is 250 ml, with a recommended frequency of 3-7 times per day depending on the patient^s energy needs. Keywords: Diabetes Mellitus, Enteral Formula, Red Dragon Fruit, Tempe Share Link | Plain Format | Corresponding Author (Celine Jessica Daniels)

75	Other	ABS-16
ANALYSIS OF SERUM VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND ANGIOTENSIN-CONVERTING ENZYME (ACE) LEVELS IN PREGNANT WOMEN WITH PREECLAMPSIA AND NORMOTENSION IN MADURA: A CASE-CONTROL STUDY Zakkiyatus Zainiyah, Eny Susanti, Novita Wulandari, Iswahyudi, Mohammad Amin 1Department of Midwifery, Noor Huda Mustofa University, Bangkalan 69116, East Java, Indonesia. Email: mail[at]universitasnhm.ac.id 2Institute of Tropical Disease, Airlangga University, Surabaya, 60286, East Java, Indonesia Abstract ABSTRACT Preeclampsia is an idiopathic multisystem condition characterized by hypertension (&#8805-140/90 mmHg) and proteinuria (&#8805-300 mg/24 hours) after 20 weeks of gestation. Several biomarkers, such as VEGF and ACE, are indicative of preeclampsia. This study aimed to analyze serum levels of vascular endothelial growth factor (VEGF) and angiotensin-converting enzyme (ACE) in normotensive and healthy pregnant women in Madura: a case-control study. The study design was case-control, with serum VEGF and ACE levels as the independent variables, and preeclampsia as the dependent variable. The sample size was 50 pregnant women, a control group of 25 healthy pregnant women, and 25 pregnant women at risk for preeclampsia, including those aged <20 and >35 years, a history of chronic hypertension/preeclampsia, a family history of hypertension, diabetes mellitus, and kidney disease. Serum VEGF and ACE levels were examined at the ITD of Airlangga University, and anxiety in pregnant women was assessed using the DASS-21 questionnaire, Chi-square, and Mann-Whitney statistical tests. The study^s results revealed a significant difference in serum VEGF biomarker levels between preeclamptic and normotensive women (p=0.003), and a significant difference in serum ACE levels (p=0.002). Serum VEGF and ACE levels are markers of preeclampsia, with higher levels found in women with preeclampsia compared to those with normotensive. Early detection and prenatal care are recommended for all pregnant women, starting in the first trimester, to enable early screening for preeclampsia and provide appropriate preventive care. Keywords: ACE, Normotension, Preeclampsia, Pregnant, VEGF Share Link | Plain Format | Corresponding Author (Zakkiyatus Zainiyah)

76	Other	ABS-18
Characteristic of Diabetic Foot Ulcer Patients Across Varying Clinical Outcomes: Diabetic Foot Registry of a National Referral Hospital in Indonesia Eni Iswati (a), Em Yunir (a,b*) a) Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. b) Metabolic Disorder, Cardiovascular and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. *e.yunir[at]ui.ac.id Abstract Background: Diabetic foot ulcer (DFU) is a common complication in diabetes. There are some outcomes of DFU, including healing, amputation, and mortality. Identifying of DFU characteristics is crucial to predict the prognosis. Purpose: This study aimed to describe characteristics of DFU patients across varying clinical outcomes. Methods: A retrospective cohort study was conducted using diabetic foot registry. This study involved DFU patients from January 2019 to December 2024. Comparability of characteristics between outcome groups was assessed using Chi-Square test for categorical variables and One-way ANOVA or Kruskal-Wallis for continuous variables. Results: This study involved 286 DFU patients with different outcomes, including amputation (112 patients), mortality (36 patients), and those discharged without amputation and mortality (120 patients). There was a significant difference in severity of infection (p<0.001), number of lesions (p=0.040), osteomyelitis (p=0.002), leukocyte (p<0.001), NLR (p<0.001), and albumin (p <0.001) between the outcome groups. The mortality group had the highest proportion of severe infection (83.3%) and the number of lesions of more than six areas (30.6%), and also had the highest levels of leukocyte (21,735/&#61549-L) and NLR (14.7), with the lowest albumin (2.4 g/dL). The highest proportion of osteomyelitis was found in the amputation group (91.7%). Meanwhile, those without amputation and mortality had the lowest proportion of severe infection (53.3%) and the number of lesions more than six areas (12.2%), and also had the lowest of leukocyte levels (14,940/&#61549-L) and NLR (8.1), with the highest level of albumin (2.9 g/dL). Conclusion: Mortality group had the highest proportion of severe infection and the number of lessions more than six areas, and had the highest levels of leukocyte and NLR, with the lowest of albumin. It was contrary to those without amputation and mortality. Meanwhile, amputation group had the highest proportion of osteomyelitis. Keywords: Diabetic foot ulcer, amputation, mortality, without amputation and mortality Share Link | Plain Format | Corresponding Author (Eni Iswati)

77	Other	ABS-55
Impact of Clinical Pathway Implementation on Length of Stay in Ischemic Stroke Patients Telly Purnamasari1*, Rizaldy Pinzon2, Ratna Djuwita Hatma3, Ajeng Tias Endarti4 1)National Research and Innovation Agency, Cibinong, Bogor, 16911, Indonesia *tellypramadi[at]gmail.com 2)Bethesda Hospital, Gondokusuman, DI Yogyakarta, 55224, Indonesia 3)Faculty of Public Health, Universitas Indonesia, Depok, West Java 16424, Indonesia 4(Faculty of Public Health, Universitas MH Thamrin, Central Jakarta, 10440, Indonesia Abstract Length of stay (LOS) is an important indicator of hospital service quality. Prolonged LOS is often associated with higher treatment costs, increased risk of nosocomial infections, and decreased quality of care. A clinical pathway (CP) is a multidisciplinary guideline designed to standardize clinical management across professions while improving efficiency. In Indonesia, evidence regarding the impact of CP remains limited and previous findings are inconsistent. This study aimed to evaluate the effect of CP on LOS among patients with ischemic stroke. A retrospective cohort was conducted using data from three hospitals that have maintained a Stroke Registry since 2012, with data collected between November 2015-September 2016. A total of 651 medical records of ischemic stroke patients were analyzed, consisting of 462 with CP and 189 without CP. The median LOS was determined using Receiver Operating Characteristic (ROC) analysis and categorized as short (&#8804-8 days) or long (>8 days). Multivariate Cox regression was applied to assess the effect of CP on LOS while adjusting for potential confounders including age, sex, comorbidities, clinical factors, service processes, and management support. The results showed that the implementation of CP significantly reduced the risk of long LOS (>8 days) by 53% after controlling for disease severity, management support, and service processes (HR: 0.47- 95% CI: 0.24-0.93- p=0.020). These findings highlight the importance of CP as a hospital management strategy. Consistent implementation, coupled with routine monitoring and evaluation, is recommended to enhance care quality and efficiency. Keywords: clinical pathway, length of stay, ischemic stroke, hospital service quality Share Link | Plain Format | Corresponding Author (Telly Purnamasari)

78	Other	ABS-92
GAME MEDIA IN ENHANCING EMOTION REGULATION AMONG ADOLESCENTS IN SCHOOLS: A LITERATURE REVIEW Nur Indah Chairunnisa1* , Dwi Sarwani Sri Rejeki 2 , Siwi Pramatama Mars Wijayanti 3 123 Department of Public Health, Postgraduate Program, Faculty of Health Sciences, Jenderal Soedirman 2 Research Centre of Rural Health, Institute for Research and Community Service, Jenderal Soedirman University, Indonesia Abstract Background: Effective emotion regulation is important for the well-being of adolescents, yet many teenagers struggle to manage their emotions. Game media is viewed as an innovative approach to enhance emotional regulation skills in the school context. Purpose: This study aims to examine various types of game media used to enhance emotional regulation among adolescents in schools through a systematic review. Method: The literature search was conducted in PubMed, ScienceDirect, and Google Scholar using the PRISMA protocol. Six articles that met the inclusion criteria were analyzed, including modified card games, digital games, and biofeedback-based serious games. Results: Card games like UNO and Truth or Dare are effective in enhancing emotional awareness and emotion management skills. Digital games, especially those that incorporate biofeedback, have shown effectiveness in reducing symptoms of anxiety and depression, as well as improving impulse control and self-efficacy. Conclusions: Game media is a potential alternative for improving emotional regulation among adolescents in schools. However, the variability in study designs, lack of long-term evaluations, and limitations of measurement tools pose challenges that need to be addressed in future research. Keywords: Intervention- Game Media- Emotion Regulation- Adolescents Share Link | Plain Format | Corresponding Author (Nur Indah Chairunnisa)

79	Other	ABS-107
The Correlation Between Gastrointestinal Tract Disorders and Organoleptic Quality of Food with Remaining Soft Food of Patients in RS Ananda Purwokerto Marvina Saputri, Hiya Alfi Rahmah, Izzati Nur Khoiriani Universitas Jenderal Soedirman, Purwokerto, Indonesia Abstract Background: Patient food waste are a consideration in assessing patient^s nutritional intake. Inadequate nutrition intake leads a risk of malnutrition in patients. The purpose of this study was to determine the relationship between gastrointestinal tract disorders and organoleptik quality of food with remaining soft food of patients at Ananda Purwokerto Hospital. Methods: This type of quantitative research is an analytic observational design with a cross sectional approach. The research subjects were taken using the total samping method. Total sample was 54 respondents aged >18 years by oberving the inclusion an exclusion criteria. Data were obtained by interview using a gastrointestinal tract disorder dan organoleptic quality questionnaire also comstock visual analysis. The results were analyzed using chi square test. Results: Data was collected at lunchtime from patients who received soft food. Bivariate analysis showed a correlation between gastrointestinal tract disorders and food waste of staple foods (p=0.029), animal proteins (p=0,004), vegetable proteins (p=0,002), and vegetables (p=0,032). There was a correlation between the taste of staple foods (p=0,011), animal proteins (p=0,024), vegetable proteins (p=0,001), vegetables (p=0,025), and fruit (p=0,000) with soft food waste. There was a correlation between the smeel of vegetable proteins (p=0,006), vegetables (p=0,002), and fruit (p=0,001) with soft food waste. In addition, there was a correlation between fruit temperature (p=0,007) and soft food waste. Conclusion: A total of 53,7% patients who received soft food had gastrointestinal tract disorders. There was a correlation between gastrointestinal tract disorders with soft food waste of staple foods, animal proteins, vegetable proteins, and vegetables. In addition, there was a correlation between the taste of staple foods, animal proteins, vegetable proteins, vegetables, and fruits- the aroma of vegetable proteins, vegetables, and fruits- and the temperature of fruits with soft food waste. Keywords: Gastrointestinal tract disorders, Organoleptic quality, Food waste, Soft food Share Link | Plain Format | Corresponding Author (Marvina Saputri)

80	Pharmaceutical Sciences and Clinical Pharmacy	ABS-4
Isoflurane and Sevoflurane in the Operating Room: A Comprehensive Meta-Analysis of Efficacy and Safety Made Suandika1, Rahmaya Nova Handayani1, Kevin Virirey Mondawitu1, M. Kabil Mubarrak, Yuniar Melissa Kisdyanti1 1Department of Anaesthesia, Faculty of Health Sciences, Harapan Bangsa University, Indonesia Abstract Background: Volatile anesthetics like isoflurane and sevoflurane are commonly utilized to maintain general anesthesia. Although both agents have well-documented safety profiles, their relative effectiveness in influencing perioperative outcomes remains unclear. Objective: The purpose of this study was to evaluate and compare the clinical effectiveness and safety of isoflurane and sevoflurane in adult patients receiving general anesthesia, employing a non-inferiority approach. Methods A systematic review and meta-analysis were performed in accordance with the PRISMA 2020 guidelines. Four electronic databases were systematically searched for randomized controlled trials (RCTs) that compared isoflurane and sevoflurane in adult patients undergoing surgery. The primary outcomes assessed were 30-day mortality and intensive care unit (ICU) stay lasting 48 hours or more, while the secondary outcomes included extubation time, incidence of myocardial injury, need for hemodynamic support, and overall length of hospital stay. Results A total of nine randomized controlled trials involving 2,176 patients were analyzed. Isoflurane demonstrated non-inferiority to sevoflurane regarding the composite primary outcome (RR = 0.85, 95% CI: 0.67-1.09- p = 0.21). No significant differences were found between the two anesthetics in terms of extubation time, postoperative troponin levels, length of ICU or hospital stay, or vasopressor use. Both agents were linked to low 30-day mortality rates and stable intraoperative hemodynamics. These results support the clinical equivalence of isoflurane and sevoflurane across major perioperative outcomes. Conclusion: Isoflurane continues to be a safe and effective alternative to sevoflurane for general anesthesia and may be particularly advantageous in settings with limited resources due to its lower cost. The selection of anesthetic agents should be guided by patient-specific considerations, institutional guidelines, and available resources, rather than assumptions of pharmacologic superiority. Keywords: Anesthesia, General Anesthesia, Isoflurane, Sevoflurane, RCT, Hemodynamics, Volatile Share Link | Plain Format | Corresponding Author (Yuniar Melissa Kisdyanti)

81	Pharmaceutical Sciences and Clinical Pharmacy	ABS-30
DRPs ANALYSIS OF DRUG USE IN PATIENTS WITH MENTAL DISORDERS AT BURNEH HEALTH CENTER, BANGKALAN REGENCY Riyadatus Solihah(1)*, M.Shofwan Haris(2)*, Homsya Al Madina S(3)* 1) NOOR HUDA MUSTOFA UNIVERSITY 2) NOOR HUDA MUSTOFA UNIVERSITY 3) NOOR HUDA MUSTOFA UNIVERSITY Abstract Mental disorders are a global health problem that requires serious attention, including in Indonesia. Treatment of mental disorders often involves the use of psychotropic drugs, such as antipsychotics and antidepressants, which have the potential to cause drug-related problems or Drug Related Problems (DRPs). Drug Related Problems (DRPs) are conditions or events related to drug use that can interfere with the achievement of desired health outcomes by patients. The purpose of this study was to analyze and identify drug-related problems (Drug-Related Problems) in patients with mental disorders at the Burneh District Health Center, Bangkalan Regency. This study used a cross-sectional design, by seeking information related to drugs consumed by mentally ill patients while also looking at the types and incidence of DRPs (Drug Related Problems) at the Burneh Health Center, Bangakalan Regency. The results of this study found various types of DRPs were found in patients, including inappropriate indications, drug interactions, non-compliance with drug use, and drug side effects. There was a significant relationship between the number of drugs consumed and the presence of comorbidities on the occurrence of DRPs. Drug Related Problems (DRPs) in the category of drug selection that occurred most often were drug interactions (56.5%), followed by inappropriate drugs due to contraindications (19%), inappropriate duplication of active substances (8.7%), inappropriate drugs according to treatment guidelines (8.7%), indications without drugs (5.1%), too many drugs for the same disease indication (1.5%), and drugs without indications (0.5%). DRPs analysis in this study obtained a significant value (p = 0.040) related to the relationship between comorbidities and the occurrence of DRPs and a significant value (p = 0.001) related to the number of drugs with the occurrence of DRPs. DRPs analysis is important to improve the safety and effectiveness of drug therapy in patients with mental disorders. An active role of pharmacists is needed in early detection of DRPs and optimizing patient therapy. Keywords: Analysis, Mental Disorders, DRPs Share Link | Plain Format | Corresponding Author (apt. Riyadatus Solihah, S.Farm., M.Si.)

82	Pharmaceutical Sciences and Clinical Pharmacy	ABS-33
Development of GESDUA: A Mobile Health Application to Reduce Potentially Inappropriate Medications in Geriatric Prescriptions Laksmi Maharani1*, Fita Rahmawati2, Zullies Ikawati2, Mustofa3 (1) Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University (2) Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University (3) Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University Corresponding author: Laksmi Maharani (laksmi.maharani[at]unsoed.ac.id) Abstract Background: Potentially inappropriate medications (PIM) are prevalent in 33-63% of geriatric prescriptions in Indonesia, posing substantial risks to patient safety. While explicit PIM criteria are available for screening, their routine application in clinical practice remains limited. Digital health solutions offer an opportunity to integrate evidence-based screening into prescribing workflows. Purpose: This study aimed to develop and evaluate the Geriatric Safe Drugs Use Application (GESDUA), a mobile- and web-based tool designed to reduce PIM in geriatric care. Methods: A research and development design were employed using the ADDIE instructional design framework to create the GESDUA. The process involved: (1) needs analysis through focus group discussions- (2) application design and development- (3) early evaluation through content validity, criterion validity, and reliability testing- (4) implementation via pilot testing using a pre-post design involving 33 patients at the geriatric clinic of Dr. Sardjito General Hospital, Yogyakarta, to assess the impact of GESDUA on reducing PIM- and (5) final evaluation of user satisfaction among 22 physicians and pharmacists in a cross-sectional survey. Results: GESDUA^s main features include PIM analysis, potential drug-drug interaction analysis, and recommendations for drug use in patients with renal impairment. During implementation, GESDUA reduced PIM prevalence by 6.01% (p > 0.05). The user satisfaction index was 78.63%, indicating a high level of satisfaction. Conclusion: GESDUA is a novel, evidence-based digital intervention that supports safer prescribing for older adults. While initial implementation reduced PIM prevalence modestly, broader, and more targeted deployment is warranted to achieve significant clinical impact. Keywords: potentially inappropriate medications, geriatrics, digital health Share Link | Plain Format | Corresponding Author (Laksmi Maharani)

83	Pharmaceutical Sciences and Clinical Pharmacy	ABS-42
Phenytoin Intoxication: A Narrative Review of the Pharmacokinetic Parameters Influencing Toxicity Wening Wulandari (a*), Vidiya Gunarsih (a), Windy Setiyanti (a) Department of Pharmacy, Faculty of Health Sciences, Jenderal Soedirman University Abstract This narrative review discusses the pharmacokinetic parameters of phenytoin and their impact on toxicity. Phenytoin is a cornerstone anticonvulsant medication used to treat seizures that stabilize the electrical activity of neurons in the brain. However, its complex and often unpredictable pharmacokinetic profile causes severe and life-threatening symptoms when taken in excessive long-term administration. Phenytoin toxicity is primarily caused by the drugs pharmacokinetic profile within the body, encompassing its absorption, distribution, metabolism, and excretion parameters. Several other factors can also influence the drugs fate within the body, including age, genetics, liver function, kidney function, interaction with other medications, and the patient nutritional status. The review examines clinical manifestations of phenytoin toxicity and provides strategic recommendations aimed at optimizing its therapeutic use to mitigate the risk of adverse effects. This article analysis was carried out using primary literature from the last ten years collected from Google Scholar, PubMed, and Cochrane online databases, with the exclusion of review articles and meta-analyses. The review concludes that a thorough understanding of the pharmacokinetic parameters influencing phenytoin toxicity is crucial for both clinicians and patients for preventing and managing intoxication, ultimately leading to improved phenytoin therapy. Keywords: phenytoin- intoxication, pharmacokinetic parameter, anticonvulsant Share Link | Plain Format | Corresponding Author (Vidiya Gunarsih)

84	Pharmaceutical Sciences and Clinical Pharmacy	ABS-54
ANALYSIS OF THE INCIDENCE OF SWITCH THERAPY FROM INTRAVENOUS TO ORAL ANTIBIOTICS IN TYPHOID FEVER PATIENTS AT RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO Syefi Nuraeni Fitriana, Gita Amanda Afriyanti Putri, Tunggul Adi Purwonugroho, Masita Wulandari Suryoputri, Dewi Latifatul Ilma, Hening Pratiwi, Nurina Mayasari Pharmacy Department of the Faculty of Health Sciences, Jenderal Soedirman University Abstract Background : Converting antibiotic therapy from intravenous (IV) to oral administration can accelerate patient discharge, reduce hospital stay, lower IV-related complications, and decrease costs. However, early antibiotic conversion for hospitalized patients is still rarely implemented in Indonesia, particularly among typhoid fever cases. Purpose : This study aims to evaluate the implementation of IV-to-oral antibiotic conversion in typhoid fever patients at Prof. Dr. Margono Soekarjo General Hospital, Purwokerto, during the period of January-December 2023, and to analyze the potential cost savings if oral antibiotic conversion were applied to clinically eligible patients. Methods: This retrospective study analyzed medical records of adult typhoid fever patients at Prof. Dr. Margono Soekarjo General Hospital, Purwokerto, from January to December 2023. A total of 201 patients were included. Data were analyzed using the Mann-Whitney and Chi-square tests. Cost-saving analysis was performed descriptively by comparing IV and oral antibiotic prices. Results: Only 3 patients (7.14%) underwent IV-to-oral antibiotic conversion. A total of 31 patients (79.5%) were clinically eligible for conversion but did not undergo it. Statistical analysis showed no significant association between patient characteristics and conversion implementation (p > 0.05). Cost analysis indicated that implementing conversion could result in a 37.3% reduction in antibiotic costs. Conclusion: The implementation of IV-to-oral antibiotic conversion in typhoid fever patients at Prof. Dr. Margono Soekarjo General Hospital remains very low, despite a high proportion of clinically eligible patients. Adoption of clinical guidelines, increased healthcare provider education, and hospital policies supporting antibiotic stewardship are needed to improve rational antibiotic use. Further prospective studies with more comprehensive cost analyses are recommended. Keywords: Typhoid fever, therapy conversion, antibiotics, cost savings Share Link | Plain Format | Corresponding Author (Syefi Nuraeni Fitriana)

85	Pharmaceutical Sciences and Clinical Pharmacy	ABS-56
Molecular Docking Evaluation of Mangiferin against HIV1 Reverse Transcriptase Ani Riani Hasana (a*), Naufa Hanif (a), Binar Pratama (a) Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman Jalan Dr. Soeparno, Kampus Karangwangkal, Purwokerto 53123, Indonesia *ani.riani[at]unsoed.ac.id Abstract Human Immunodeficiency Virus type-1 (HIV-1) remains one of the most pressing global health challenges, particularly due to the emergence of antiretroviral drug resistance that limits long-term treatment effectiveness. Reverse transcriptase (RT) is a key enzyme in the viral replication cycle, responsible for converting viral RNA into proviral DNA, making it an essential target for therapeutic intervention. Mangiferin, the major C-glucosyl xanthone from Mangifera indica L., has been reported to exhibit broad-spectrum antiviral activity and potential interactions with viral enzymes. Nevertheless, its specific molecular interactions with HIV-1 RT remain poorly understood. This study aims to evaluate the binding affinity of mangiferin toward two functional sites of RT: the non-nucleoside inhibitor binding pocket (NNIBP) and the RNase H domain. Molecular docking was performed using high-resolution crystal structures of RT (PDB IDs: 1FK9 for NNIBP and 3QIO for RNase H). Validation of the docking protocol was conducted through redocking of reference ligands, efavirenz for NNIBP and a raltegravir derivative for RNase H, to ensure reliability of the method. Binding free energy (&#916-G), hydrogen bonding patterns, and hydrophobic interactions were analyzed to characterize ligand-protein interactions. The expected outcomes include identification of stable binding conformations and favorable energy scores of mangiferin with RT functional sites. These results may provide preliminary evidence supporting mangiferin as a promising natural compound for development as an HIV-1 RT inhibitor, warranting further in vitro and in vivo investigations. Keywords: Mangiferin- Mangifera indica L- HIV1- Reverse Transcriptase Share Link | Plain Format | Corresponding Author (Ani Riani Hasana)

86	Pharmaceutical Sciences and Clinical Pharmacy	ABS-58
The Expectation of Willingness to Use toward Home Pharmacy Care in Tuberculosis Patients at Primary Health Care, Banyumas Regency, Central Java Nialiana Endah Endriastuti, Gerli Puspita Anggraini, Dewi Latifatul Ilma, Masita Wulandari Suryoputri, Vitis Vini Fera RU Department of Pharmacy, Universitas Jenderal Soedirman, Indonesia Abstract Background: Tuberculosis (TB) is a contagious infectious disease that remains a major global public health challenge, including in Indonesia. High morbidity and mortality rates, social stigma, and poor treatment adherence are key obstacles to TB control. Home pharmacy care is a Pharmaceutical service hopefully can improve service access and patient adherence- however, their implementation in Indonesia remains limited. Purpose: This study aims to observe TB patients expectations based on their willingness to use of home pharmacy care services at primary health care in Banyumas Regency, Indonesia. Methods: This study employed a quantitative method with a cross-sectional design and prospective data collection using a questionnaire. Total of 104 tuberculosis patients in the Banyumas were selected using accidental sampling. The Mann-Whitney U test was used to analyze differences in patients expectations toward home pharmacy care services, as well as based on their willingness to use of home pharmacy care. Results: Total of 63 respondents (56,8%) demonstrated willingness to use home pharmacy care and 41 respondents (41,3%) did not. There was a significant difference in expectations between patients who were willing and those who were not willing to use the home pharmacy care services (p < 0.001). Conclusion: Patients who have a willingness to use tend to have higher expectations of the home pharmacy care service. Targeted strategies are essential to improve patient acceptance and integration of these services into TB care. Keywords: expectation, home pharmacy care, tuberculosis, willingness to use Share Link | Plain Format | Corresponding Author (Nialiana Endah Endriastuti)

87	Pharmaceutical Sciences and Clinical Pharmacy	ABS-71
Pharmacy Students Knowledge And Perception Towards Indonesian Health Law Number 17/2023 Merlina, Tunggul Adi Purwonugroho, Dewi Latifatul Ilma, Hening Pratiwi, Vitis Vini Fera Ratna Utami Department of Pharmacy, Faculty of Health Sciences, University of Jenderal Soedirman Abstract The Health Law of the Republic of Indonesia Number 17 of 2023 constitutes a pivotal regulation governing various aspects of healthcare services, including pharmaceutical practice. As prospective pharmacists, pharmacy students must comprehend the provisions of this law to perform their professional roles accurately and in accordance with legal requirements. This study aimed to describe the knowledge and perceptions of pharmacy students regarding the Health Law No. 17/2023 and to analyze the association between gender, academic cohort, and prior enrollment in the ^Legislation and Ethics^ course with students level of knowledge. This research employed a descriptive quantitative design with a cross-sectional approach involving 100 respondents. The research instrument was a structured questionnaire developed based on the content of the law. Respondents were selected using proportional sampling. Data were analyzed descriptively and further examined using Spearman^s rank correlation test and contingency coefficient. The results indicated that 43% of respondents demonstrated a moderate level of knowledge, and 93% exhibited a positive perception toward Health Law No. 17/2023. A significant association was found between academic cohort (p = 0.002- r = 0.303) and prior enrollment in the ^Legislation and Ethics^ course (p = 0.018- r = 0.283) with the level of knowledge. In addition, a correlation was identified between students knowledge and perceptions of the law (p = 0.028- r = 0.219). Pharmacy students showed moderate knowledge but highly positive perceptions of Health Law No. 17/2023. Knowledge was significantly associated with academic cohort, prior exposure to ^legislation and ethics^ course, and positively correlated with perception. Keywords: Health Law number 17/2023- pharmacy students- knowledge- perception Share Link | Plain Format | Corresponding Author (Tunggul Adi Purwonugroho)

88	Pharmaceutical Sciences and Clinical Pharmacy	ABS-72
Exploration of Alpha-Amylase and Alpha-Glucosidase Inhibitors from Green Betel Leaf (Piper Betle L) Extract as an Antidiabetic Rianti Nurpalah, Meti Kusmiati, Meri Meri, Dikdik Kurnia, Fadhil Miftah, Iin Asriani Department of Medical Laboratory Technology, Health and Science Faculty, Universitas Bakti Tunas Husada, Jawa Barat, Indonesia Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Padjadjaran, Jawa Barat, Indonesia Abstract Backgruond: Diabetes is a metabolic disease characterized by elevated blood sugar levels due to decreased insulin secretion or impaired insulin function. Various treatments can be used to manage diabetes mellitus, including the use of herbal plants. Green betel leaf is a plant that has antibacterial, analgesic, and antidiabetic properties due to its various secondary metabolites, such as alkaloids, flavonoids, and tannins. One method of treating diabetes is by inhibiting the enzymes that break down carbohydrates into glucose. Purpose: The aim of this study was to determine the antidiabetic activity of green betel extract in inhibiting the activity of alpha-amylase and alpha-glucosidase enzymes in vitro by measuring the IC50 value. Methods: Betel leaf extract was prepared by maceration using methanol, followed by evaporation of the solvent to obtain a thick extract. The resulting extract was phytochemically tested to determine its secondary metabolite content. In vitro enzyme inhibition was measured using a spectrophotometer, and the IC50 values for each enzyme, alpha-amylase and alpha-glucosidase, were calculated. Result: Phytochemical test results showed that green betel leaf extract contains alkaloids, plafonoids, tannins, steroids, saponins, phenols, and quinones. In vitro inhibition tests of alpha-amylase and & alpha-glucosidase enzymes yielded an IC50 value of 3.63% for the alpha-amylase enzyme and an IC50 value of 13.13% for the alpha-glucosidase enzyme. Conclusion: From the results of this study, it can be concluded that green betel leaf extract has the ability to inhibit the activity of alpha-amylase and alpha-glucosidase enzymes, but it is weak because the IC50 value obtained is high. Keywords: Inhibitors Enzyme, Green Betel Leaf, Antidiabetes Share Link | Plain Format | Corresponding Author (Rianti Nurpalah)

89	Pharmaceutical Sciences and Clinical Pharmacy	ABS-76
Quantitative Structure-Property Relationship (QSPR) of Active Compounds from Momordica charantia (Bitter Melon) as Antidiabetic Agents Septian Aditya Pratama (a), Ani Riani Hasana (b*), Missionira Dhesrina Viryanaluri Wea (a), Adella Vrida Rennata (a), Sahrul Muslimin (a) a) Undergraduate Pharmacy Study Program, STIKes Panti Waluya Malang Jl. Yulius Usman No. 62, Malang 65111, Indonesia b) Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman Jl. Dr. Soeparno, Karangwangkal, Purwokerto 53122, Indonesia Abstract Momordica charantia (bitter melon) contains several active compounds, including momordenol, lanosterol, cucurbitacin, stigmasterol, and cucurbitin. These five active constituents of Momordica charantia L. were identified from previous research databases and investigated to determine the relationship between their physicochemical parameters and their predicted antidiabetic activity using a Quantitative Structure-Property Relationship (QSPR) model. Diabetes mellitus remains a major global health problem, particularly in low- and middle-income countries, where herbal medicines such as M. charantia offer promising and affordable therapeutic alternatives. In this study, physicochemical parameters including lipophilic (logP, logS), electronic (Etot, pKa), and steric (MR, BM) properties were calculated using ChemBioDraw 2D Ultra, ChemBioDraw 3D Ultra, and ChemBio3D Ultra. Molecular docking was performed with Molegro Virtual Docker against the phosphorylated insulin receptor tyrosine kinase (PDB: 1IR3), while statistical analyses were conducted with Microsoft Excel generate QSPR models. The best regression equation was selected based on correlation coefficient (r), determination coefficient (R2), standard error (SE), F value, and significance. The optimum QSPR equation obtained was: Rerank Score = (-0.356MR) - 33.915 (n = 5- r = 0.995- R2 = 0.9908- SE = 1.919- F = 321.35- sig = 0.0003). The results indicate that the physicochemical parameter most strongly associated with antidiabetic activity is the relative molecular mass (MR). These findings highlight the potential of M. charantia bioactive compounds, particularly cucurbitacin, as promising candidates for future development of natural antidiabetic agents through computational and experimental approaches. Keywords: Antidiabetic- Momordica charantia- QSPR Share Link | Plain Format | Corresponding Author (Ani Riani Hasana)

90	Pharmaceutical Sciences and Clinical Pharmacy	ABS-78
Analysis of Pharmaceuticals Inventory Management in Indonesian Vertical Hospitals Wening Wulandari1*, Nurina Mayasari1, Suci Wulan Sari1 1Department of Pharmacy, Faculty of Health Sciences, Universitas Jenderal Soedirman, Indonesia Abstract Background: Pharmaceutical inventory management is a critical component of hospital operations, ensuring the availability of necessary medications while maintaining cost efficiency. Vertical hospitals in Indonesia, which integrate education, research, and healthcare services, face unique challenges in managing their pharmaceutical inventories. Purpose: The purpose of this study was to evaluate pharmaceutical inventory management using the ABC analysis method to identify expenditure distribution and drug utilization. Methods: A retrospective descriptive study was conducted using procurement data from 36 vertical hospitals in Indonesia during the 2023 fiscal year. The Always Better Control (ABC) analysis method was applied by ranking all pharmaceutical items based on their annual expenditure values. Results are presented for the three hospitals with the highest pharmaceutical expenditures. Results: The analysis revealed that three hospitals had the highest annual expenditure values: RSUP Dr. Cipto Mangun Kusumo, RSUP Dr. Sardjito, and RSUP Dr. Kariadi. The budget allocation for RSUP Dr. Cipto Mangun Kusumo included IDR 165,508,648,832 for Category A (9% of the items), IDR 47,239,522,945 for Category B (19% of the items), and IDR 22,462,773,059 for Category C (72% of the items). RSUP Dr. Sardjito allocated IDR 120,674,196,063 for Category A (12%), IDR 34,766,007,513 for Category B (18%), and IDR 16,320,424,039 for Category C (71%). RSUP Dr. Kariadi spent IDR 107,444,789,747 for Category A (12%), IDR 30,936,408,244 for Category B (19%), and IDR 15,414,852,730 for Category C (69%). Across hospitals, Category A medicines consumed the majority of expenditures despite representing the smallest proportion of items. Conclusion: Pharmaceutical expenditures in Indonesian vertical hospitals are concentrated on a limited number of high-cost drugs, while the majority of items contribute minimally to total spending. Effective inventory management practices are essential for improving cost efficiency and ensuring optimal pharmaceutical supply in vertical hospitals in Indonesia. Keywords: Please Just Try to Submit This Sample AbstDrug Inventory Management, ABC Analysis, Planning, Hospital Pharmacyract Share Link | Plain Format | Corresponding Author (Wening Wulandari)

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