THE LEVEL OF SOLUBLE FMS-LIKE TYROSINE KINASE 1 (SFLT-1) OF UMBILIKAL CORD IN PREECLAMPSIA AND ITS CORRELATION WITH HYPERTENSION AND PERINATAL OUTCOME Wahida (a*), Gusriani (b), Irfan Idris (c), Nasrudin A. Mappaware (d)
a)Midwifery Department Stikes St. Fatimah Mamuju, Indonesia
*idha.soenardi[at]gmail.com
b) Midwifery Department Faculty of Health Sciences Borneo Tarakan University, Indonesia
c) Medical Faculty of Hasanuddin University, Indonesia
d) Medical Faculty of MuslimUniversity Indonesia
Abstract
Soluble Fms like tyrosine kinase 1 (sFlt-1) is one of the markers that function on the pathogenesis of preeclampsia. This research aimed to analyze the level of sFlt-1 of umbilical cord against hypertension and the perinatal outcome in the preeclampsia mothers and the normal pregnant mothers. The research used an observational analytical study using the cross-sectional design. The sample used was the 18 delivering mothers with preeclampsia and 15 normal delivering mothers. The level of sFlt-1 of umbilical cords was examined using the ELISA method. The data were analyzed using the Mann Whitney-U test to determine the different levels of sFlt-1, the blood pressure, and the perinatal outcome in the two groups, while Spearmans Rank correlation test was to determine the correlation between the level of sFlt-1 with the blood pressure and perinatal outcome. The research results indicated that was a significant difference between the level of sFlt-1 of the umbilical cord in the preeclampsia group and that in the control group (10.693+6.535 ng/mL, 3.572+1.225 ng/mL; p<0.05). There was a significant difference between the blood pressure and the birth body weight in the two research groups (p<0.05), on the other hand, the incident of asphyxia showed no difference between the two groups (p=0.944). Here was a significant correlation between the level of sFlt-1 of the umbilical cord and the blood pressure and the pre-natal discharge (systolic blood pressure, p=0.000, diastolic blood pressure, p=0.001, birth bodyweight, p=0.008, asphyxia p=0.013).
Keywords: sFlt-1; preeclampsia; blood pressure; birth body weight; asphyxia
