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THE LEVEL OF SOLUBLE FMS-LIKE TYROSINE KINASE 1 (SFLT-1) OF UMBILIKAL CORD IN PREECLAMPSIA AND ITS CORRELATION WITH HYPERTENSION AND PERINATAL OUTCOME a)Midwifery Department Stikes St. Fatimah Mamuju, Indonesia Abstract Soluble Fms like tyrosine kinase 1 (sFlt-1) is one of the markers that function on the pathogenesis of preeclampsia. This research aimed to analyze the level of sFlt-1 of umbilical cord against hypertension and the perinatal outcome in the preeclampsia mothers and the normal pregnant mothers. The research used an observational analytical study using the cross-sectional design. The sample used was the 18 delivering mothers with preeclampsia and 15 normal delivering mothers. The level of sFlt-1 of umbilical cords was examined using the ELISA method. The data were analyzed using the Mann Whitney-U test to determine the different levels of sFlt-1, the blood pressure, and the perinatal outcome in the two groups, while Spearmans Rank correlation test was to determine the correlation between the level of sFlt-1 with the blood pressure and perinatal outcome. The research results indicated that was a significant difference between the level of sFlt-1 of the umbilical cord in the preeclampsia group and that in the control group (10.693+6.535 ng/mL, 3.572+1.225 ng/mL; p<0.05). There was a significant difference between the blood pressure and the birth body weight in the two research groups (p<0.05), on the other hand, the incident of asphyxia showed no difference between the two groups (p=0.944). Here was a significant correlation between the level of sFlt-1 of the umbilical cord and the blood pressure and the pre-natal discharge (systolic blood pressure, p=0.000, diastolic blood pressure, p=0.001, birth bodyweight, p=0.008, asphyxia p=0.013). Keywords: sFlt-1; preeclampsia; blood pressure; birth body weight; asphyxia Topic: Maternal, neonatal, and child health |
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