Review: Isolation of Mesenchymal Stem Cells from Human Breast Milk Ariyani Noviantari (a*), Putri Reno Intan (a)
a) Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Centre, Jalan Raya Jakarta-Bogor Km. 46, Cibinong, Bogor, Jawa Barat, 16911, Indonesia
* ariyani.noviantari[at]brin.go.id
Abstract
Stem cells have the ability to self-renewal cells, that have no specific shape, and function but can differentiate into other cells. Mesenchymal stem cells (MSCs) can be isolated from a variety of sources, including bone marrow, adipose tissue, dental pulp, placenta, amniotic fluid, Wharton Jelly, umbilical cord blood, breast milk, and others. Human breast milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to carbohydrates, proteins, lipids, and other biologically active components, breast milk is also reported to contain stem cells. MSCs can differentiate into different cell types but are limited to just one cell group by expressing multiple specific or multipotent markers. This paper is a review of the literature through a literature search obtained from the internet in isolation, differentiation ability, and characterization of MSCs from human breast milk. MSCs isolated from human breast milk can be isolated and express some specific markers. MSCs from human breast milk can differentiate into osteoblasts, chondrocytes, adipocytes, and. neurons Therefore, MSCs from breast milk has great potential and maybe hopefully be used in the treatment of regenerative therapy.
Keywords: breast milk, characterization, differentiation, isolation, mesenchymal stem cells
