Anti-Cancer Potential of White Turmeric Extract (Curcuma zedoaria) in Mcf 7 and Hepg 2 Cancer Cells Sri Rahayu1*, Naufal Maarif2, Dania Afifah1, Arief Prasetiyo1, Firda Kamila1, Anisa Fitriani2, Alifa Alya Aurora2, Fadila Nuranfa Putri2
1Departemenet of Biology, Faculty of Mathematics and Natural Science, Jakarta State University, Indonesia
2Departemenet of Biology Education, Faculty of Mathematics and Natural Science, Jakarta State University, Indonesia
*Corresponding email: srirahayu[at]unj.ac.id
Abstract
Abstract. White rhizome (Curcuma zedoaria) is a plant from the Zingiberaceae family that has an advantage in medicine and cancer therapy. This research aims to find the cytotoxic level of white turmeric in the MCF-7 and HepG2 cell lines. The method used in this research is experimental with a completely randomized design. The treatment group consisted of 10, 20, 25, and 50 ppm Curcuma zedoaria extract for MTT (Micro tetrazolium) test and the control group (without extract) using inhibitory concentration (IC50). The analysis data used one-way ANOVA and Post-hoc Tests. The results of the one-way ANOVA showed that the significance level of concentration on the MCF-7 cell line was 0.00 < 0.05, indicating that there was a different effect of concentration. The highest inhibition value of the white turmeric rhizome extract was shown at a concentration of 50 PPM with an inhibition level of 61.86%. The significance level of the one-way ANOVA for the HepG2 cell line was 0.02 < 0.05, so there was no change in the effect of concentration on cancer cells. The highest inhibition value in HepG2 cancer cells was 18.83% and lower than the MCF-7 cell line. The results showed that the highest IC50 value for the MCF-7 cell line was 68.58ppm, and the HepG2 cell line was 40 PPM. It can be concluded that white rhizome extract has a cytotoxic effect on MCF-7 and HepG2 cell lines.
Keywords: White rhizome, Anti-Cancer, IC50, MCF7, HepG2.
