Fabrication and Characterization of Cellulose Acetate Nanofiber Derived from Rice Husk as a Potential Wound Dressing Material Aryanny Nasir, Saiful Izwan Bin Abd Razak and Siti Pauliena Mohd Bohari
Department of Bioscience, Faculty of Science, Universiti Teknologi Malaysia, Johor
Bahru, 81310, Johor, Malaysia
School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, 81310, Johor, Malaysia.
Cosmetic and Fragrance Laboratory, Institute of Bioproduct Development, Universiti Teknologi Malaysia.
Abstract
Electrospun nanofibrous mat have been fabricated from a variety of natural and synthetic polymers and ideal for wound dressing applications. Due to their appealing characteristics, natural polymers have attracted a lot of attention. Hence, the use of cellulose derived from agricultural waste becomes crucial as a green alternative to produce electrospun wound dressing. The feasibility of preparing cellulose acetate (CA) nanofiber derived from rice husk (RH) through electrospinning process and investigating its wettability for potential application as wound dressing was reported. Different CA concentrations of 15 percent, 16 percent and 20 percent (w/v) were fabricated and labelled as CA15, CA16, and CA20 respectively. The morphology and wettability of the prepared CA nanofiber was studied using scanning electron microscopy and static contact angle measurements. The scanning electron microscope (SEM) images showed continuous fiber with diameter ranging from 100-600 nm with good adhering of the human dermal fibroblast (HDF) cells onto the CA nanofiber. The results also showed that the electrospun membrane gave a contact angle of 127.2o, 125.8o, 108.6o for CA15, CA16, and CA20, respectively. Higher concentrations of CA resulted in bead-free fibres with higher porosity. CA20 has excellent porosity of 76.09\pm1.57, which is essential for scaffoldings. Based on the findings, it could be concluded that the fabricated electrospun mat derived from RH could be potentially applied as wound dressing for successful wound healing.
