THE EFFECT OF PLUM (Prunus salicina Lindl) FRUIT FLESH ETHANOL EXTRACT ON MDA LEVELS OF MALE WISTAR RATS INDUCED BY HIGH FAT DIET Hendri Priyadi (a*), Indarti Trimurtini (a**), Fransiska Ambarukmi Pontjosudargo (a***)
a) Faculty Of Medicine, Jenderal Achmad Yani University
*henpri74.hp[at]gmail.com
**indar_asoparie[at]yahoo.com
***ambarukmifransiska[at]gmail.com
Abstract
This study was conducted to assess the effect of Plum extract on liver damage with indicators of MDA levels in male rats. The target of this study was to obtain information on the benefits of natural ingredients as hepatoprotection in rats induced by a high-fat diet. A high-fat diet is expected to produce a state of fatty liver by increasing the liver MDA. This research is a laboratory study with a completely randomized design, using 25 samples which were grouped into 5 groups consisting of 5 rats, which are a negative group, a positive group, and three treatment groups who were given ethanol extract of plum dose of 0,8 mg/kg BW/day, 1,6 mg/kg BW/day and 2,4 mg/kg BW/day. The negative group was only given standard pellets while the rest were given a high-fat diet and induced by propylthiouracil. The indicator that will be assessed is the liver MDA. The data obtained were analyzed using analysis of variance (ANOVA) and further tests were carried out with Duncan^s test, with a 95% confidence degree. The results showed that the liver MDA levels in the group given Plum fruit extract at doses of 0.8 mg/kg BW and 1.6 mg/kg BW were significantly lower than the positive control group. Plum fruit extract was able to inhibit the increase in liver MDA levels at an effective dose of 0.8 mg/kg BW.
Keywords: Antioxidants, High Fat Diet, Plum Extract, Liver MDA
