The Relationship of Neutrophil-Lymphocyte Ratio Value to the Severity of COVID-19 Patients Silvia Andina Yelsi, Rika Nilapsari
Instalasi Laboratorium Patologi Klinik, RSUD Cicalengka, Kab. Bandung, Indonesia
silviaandinayelsi[at]gmail.com
Abstract
At the end of December 2019 in Wuhan, there was a group of patients with respiratory symptoms diagnosed as pneumonia of unknown etiology. After looking for the cause of this virus is SARS-CoV2, a new Coronavirus^s types. This disease was named by WHO as COVID-19. Peripheral hematological changes in severe COVID-19 patients may effect an immune responses, one of which is lymphocytes. Lymphocytes can be detected as a prognosis for the severity of the disease by calculating the neutrophil-lymphocyte ratio (NLR). The measurement of NLR is one of laboratory tests that can be used as a factor to determine the patient^s prognosis in various clinical situations. This study aims to determine the relationship between NLR values and the severity of COVID-19 patients. The method used in this research is Systematic Review by analyzing scientific articles from 3 databases, namely SpringerLink, ProQuest, and ScienceDirect, the last review was carried out using The Joanna Briggs Institute application and PRISMA diagram. Initial search results were 1,652 articles. Based on the criteria obtained 625 articles. Meanwhile, according to the PICOS exclusion criteria, there were 6 articles that matched the inclusion and exclusion criteria. The method of the 6 articles is observational consisting of cohort, cross-sectional, and case control. The neutrophil-lymphocyte ratio can be used as a predictor of the severity of COVID-19, early warning of symptoms that appear and determining treatment actions. The value of neutrophils-lymphocytes in each country can be different.
