The Effect of Topical Curcumin Gel on The Epidermal Thickness 2-4 Dinitrochlorobenzene induced Albino mice (Histopathological Analysis) Rina Munirah Bulqini (a*), Lina Damayanti (a)
(a*) Department of Dermatology and Venereology, Faculty of Medicine Universitas Jenderal Achmad Yani Jl.Terusan Jenderal Sudirman, Cimahi, Indonesia
*rinamunirah[at]gmail.com
Abstract
Introduction:1-chloro-2,4-dinitrochlorobenzene (DNCB) is an inflammatory inductor with epidermal damage as the main manifestation. Curcumin influences inflammatory signaling pathways and is a potential chemotherapeutic agent. Topical preparation can increase penetration into the skin which makes it a suitable vehicle to maximize the anti-inflammatory property of curcumin, especially through inhibition of phosphorylase kinase enzyme.
Objective: To determine the effect of topical application of Curcumin extract gel with various concentrations on the epidermal thickness DNCB-induced albino mice.
Methods: Mice were divided into six groups: control (no treatment was given), DNCB induction, DNCB and base gel, and three treatment groups in which in addition to DNCB induction, Curcumin extract gel 2%, 4%, and 8% were applied to the back of mice. After 72 hours, histopathological examination was performed to assess epidermal thickness.
Results: From a total of 30 mice, no significant difference in epidermal thickness between the control and treatment groups was found (p>0.05).
Conclusion: There was no significant difference in the average thickness of the epidermis between the group of mice that were given the Curcumin extract gel application and the group that was not given the Curcumin extract gel.
