THE EFFECT OF RED GUAVA FRUITGHURT ON REDUCTION OF BLOOD GLUCOSE LEVELS IN STREPTOZOTOCIN INDUCED RATS Ania Kurniawati Purwa Dewi (1) Rona Jauza Husniah Dewi (2) Endry Septiadi(3)
(1)Department of Microbiology, Faculty of Medicine, Jenderal Achmad Yani University, (2)Department of General Medicine, Faculty of Medicine, Jenderal Achmad Yani University, (3)Department of Nutrition, Faculty of Medicine, Jenderal Achmad Yani University.
Abstract
Diabetes mellitus is a chronic metabolic disorder characterized by increased blood glucose levels due to decreased insulin production, insulin action or both. Red guava fruitghurt contains flavonoid phytochemical compound. This research aims to determine the effect of red guava fruitghurt on reducing blood glucose levels in rats. The research design used was laboratory experiment with an experiment approach. The subjects of this study were white rats (Rattus norvegicus) with wistar lines, where each group needed 5 rats, therefore the total was 25 rats. The sampling technique used is simple random sampling, The experimental animals are grouped into 5 groups, namely KN, KP, P1, P2, and P3. The data analysis was performed with paired t test, one way anova, pairwise comparison test and post hoc duncan. Based on the results of the paired t test, it can be concluded that the significant effect in reducing blood glucose levels is the P3 (the rats induced by streptozotocin, given glibenclamide, and given fruitghurt). The decrease in blood glucose level is probably caused by the mechanism of glibenclamide and fruitghurt. Glibenclamide will stimulate pancreatic β- cells to increase insulin secretion. Giving fruitghurt can reduce blood glucose levels due to the mechanism of action of probiotics toward the body^s defences by strengthening the E-cadherin/Beta-cetanin complex so that it can improve intestinal permeability and the role of red guava which has a high content of flavonoids and total phenolic that works as a potent GLUT2 and SGLT1 inhibitor both in vitro and in vivo.
Keywords: Fruitghurt, Red Guava, Blood Glucose Levels, Rats, Streptozotocin
