Utilizing Pterygoplichtis pardalis fish bone as material of bone graft for bone remodelling in periodontitis Nursyamsi Djamaluddin, Nurlindah Hamrun, Nursinah Amir, Muhammad Nur Amir, Andi Apriliiqa Megumi Adhila Larasati, Rahma Sania Syahrir, Shaffati Shaffa
Universities Hasanuddin
Abstract
Periodontitis is a disease that results in tooth loss due to alveolar bone resorption. Bone grafting can be used to restore damage to the periodontal tissues of the teeth. The calcium, phosphate, and hydroxyapatite concentration of plecos catfish (Pterygoplichtis pardalis) is over 70%. This has the potential to be developed into a bone transplant material that is an alternative to hydroxyapatite. Aim: The purpose of this study was to determine the quality of HA of P. pardalis fish bone as a bone graft material during the bone remodeling stage, as well as the effect of P. pardalis fish bone as a bone graft material during the bone formation phase on the bone remodeling process. Method: This is an experimental study using a pre and post test only group design, with four groups of test animals: group one received no treatment- group two received 100 percent HA fish P. pardalis hydrothermal process- group three received 100 percent HA beef/bovine bone- and group four received 50 percent HA fish P. pardalis hydrothermal method and 50 percent HA beef/bovine bone. After that, the samples were subjected to an ELISA test, a radiography test, and a histopathological test. Results: The HA powder of P. pardalis fishbones is non-toxic, high in PO43- , CO32- and OH-, increasing of TNF-α- shown as inflammation condition of periodontal tissue disease, defect is not covered perfectly by radiograph, and HA of P. pardalis bonefish can stimulate amount of osteoblast cells. Conclusion: P. pardalis fish bone HA has the potential to be used as a bone graft.
Keywords: bone remodelling, bone resorption, hydroxyapatite, periodontitis, plecos catfish bone
Topic: Marine and Fisheries Biotechnology (International)
