Molecular docking study of Halymenia durvillei extract (Rhodophyta) against VP26 Protein of White Spot Syndrome Virus Asmi Citra Malina A.R. Tassakka*(a), Israini Wiyulanda Iskandar(b) , Kasmiati (a) , Jamaluddin Fitrah Alam (a), and Widyastuti Umar (a)
(a)Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia
(b)Center for Excellence in Science and Technology of the Development and Utilization of Seaweed (PUI-P2RL)
Abstract
Virus infections have hampered the development of shrimp aquaculture, putting a significant financial strain on the business. White spot disease (WSD) has caused significant mortality in farmed shrimp in many regions. The envelope proteins VP26 are essential in the infection process and interactions with host cells. In this recent study, the bioactive compounds from Halymenia durvillei algae have been investigated by molecular docking against VP26 protein from White Spot Syndrome Virus in Shrimp. The 37 natural compounds of Halymenia durvillei algae identified by GC/MS analysis have shown that E, E, Z-1,3,12-Nonadecatriene-5,14-diol have the highest fitness score in the GOLD calculation in molecular docking with 21.9. The docking analysis would be used to identify a drug-like molecule as an immunostimulant, which would then be optimized for a potential treatment for shrimp aquaculture. This is thought to be the role of the inhibitor, which prevents the viral protein from attaching to the receptor and therefore prevents the WSSV infection.
