Diclofenac sodium mucoadhesive patch formulation based on hydroxy propyl methyl cellulose (HPMC) for the inflammatory treatment in periodontal disease. Sabrina Dahlizar, Yuni Anggraeni, Hissi Fitriyah
Department of Pharmacy, Faculty of Health Science
Syarif Hidayatullah State Islamic University Jakarta,
Banten 15419, Indonesia
Abstract
Mucoadhesive patches containing diclofenac sodium were prepared for the inflammatory treatment in periodontal disease. The present study formulated and evaluated the characteristics of the formulated diclofenac sodium patch. Three formulation (A1, A2, A3) of the patch were prepared by varying the concentrations of hydroxy propyl methyl cellulose (HPMC) solution, 1%, 1.5%., 2 %, respectively. Patches were prepared by solvent casting method. In vitro residence time showed that all formulated patches were attached on the mucosa gingival bovine more than 7 hours. Cumulative diffusion of diclofenac sodium at sixth hours from A1, A2 and A3 were 34%, 21 % and 24%, respectively. Backing layer formed from ethyl cellulose can inhibit diffusion of diclofenac sodium as much as 97.5%. From these result, diclofenac sodium patch containing 1% HPMC exhibited the best property.
