STUDY FORMULATION AND ANTIBACTERY TEST ELIXIR ETHANOL EXTRACT OF UNRIPE WOOD BANANA FRUIT (Musa paradisiaca L.) Arista Wahyu Ningsih1 Ali Kosim2 Yani Ambari3
1 Department of pharmaceutical biology,Anwar Medika University
2Pharmacy study program, Anwar Medika University
3 Department of pharmaceutical technology,Anwar Medika University
Abstract
Senduro Village, Lumajang, East Java. unripe wood banana is used to treat diarrhea. There are active compounds used as antidiarrheal in unripe wood banana fruit, therefore it is necessary to innovate to become new preparations of these compounds, one of which is an elixir. The purpose of this study was to formulate and test the antibacterial elixir of the ethanol extract of unripe wood banana fruit. The method used for the antibacterial test is the disc diffusion method. The elixir was prepared using a mixing method and a stability test was carried out including the organoleptic test, pH, specific gravity and viscosity of the preparation. The extraction results from 1000 grams of simplicia obtained a yield value of 6.51%. Phytochemical screening of ethanol extract of unripe wood banana fruit identified alkaloids, flavonoids, saponins, tannins and polyphenols. The physical stability of the elixir in the 3 formulations showed that the organolpetis had a distinctive banana smell, brownish yellow color, starchy deposits, and a sweet taste. pH is measured by universal pH and constant at pH 4. Bj of the preparation obtained is under the conditions 1.21-1.23 g / cm3. The viscosity of the preparations was mean (FI = 1.00 mPa.s), (FII = 1.00 mPa.s) and (FIII = 2.00 mPa.s). the elixir that was made showed unclear results due to a precipitate. The precipitate is in the form of starch which is produced from thick extract, which in bananas has a high starch content. The three formulas were tested for antibacterial disc diffusion method on Escherichia coli bacteria. The conclusion of this study is that the organoleptic test is not suitable because there are still deposits that are formed and the BJ is less than the requirements. at pH and viscosity of the preparation have met the criteria. The largest zone of inhibition obtained in the three formulas is formula 3 of 6 mm.
