Risk Factors for Tuberculosis Treatment Failure: A Case Control Study in Kendari, Indonesia Mita Restinia*, Nurmeilis, Amand Dwi Alley Nisa.
Department of Clinical and Community Pharmacy Faculty of Health Sciences Islamic State University of Syarif Hidayatullah Jakarta, Indonesia
Abstract
Tuberculosis treatment failure is a serious public health problem in the world. Therefore, this study was conducted using case-control method to analyze the risk factor of unsuccessful tuberculosis treatment among registered pulmonary tuberculosis outpatients for period of year 2018-2020 and minimum age of 18 years old in one public hospital in Kendari, Indonesia. A total of 240 sample sizes (120 cases and 120 controls) were enrolled in this study. According to multivariate logistic regression analysis, the patients with ages more than 60 years were almost seven times more risk to become treatment failure than under 60 years (OR= 6.9, 95% CI 3-16, P 0.000). Patients who ungraduated from university were found to have unsuccessful more than twice (OR= 2.1, 95% CI 1-4.3, P 0.044). Distance to hospital more than 10 km was analyzed to increase the treatment failure by more than 6 times (OR= 6.5, 95% CI 3.1-13.5, P 0.000). Patients who diabetes mellitus status were more than three times to develop the failure of treatment (OR= 3.6, 95% CI 1.7-7.6, P 0.001). Patients with HIV were found to become the treatment failure more than sixteen times (OR= 16.3, 95% CI 2.7-97.5, P 0.002). Adverse drug reaction was identified to rise the treatment failure by more than three times (OR= 3.3, 95% CI 1.6-6.7, P 0.001). This study highlighted that tuberculosis treatment failure is influenced by the sociodemographic and clinical status of patients. Hence, The effort of achieving successful tuberculosis treatment needs to be concerned about these issues.
