Comparison of Endothelin-1, Nitric Oxide and Roll Over Test on Preeclampsia and Normotensi Irfan Idris (1), Isharyah Sunarno (2), Andriany Qanitha (1), Melicha Kristine Simanjuntak (3), Indri N Marasing (3), Sharvianty Arifuddin (3), Andi Wardihan Sinrang (1), Burhanuddin Bahar (1)
1) Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Indonesia
2) Department of Obstetrics and Gynecology, Hasanuddin University, Indonesia
3) Department of Midwifery, Graduate School, Hasanuddin University, Indonesia
Abstract
Objective: This study aims to compare and analyze levels of Endothelin - 1, Nitric Oxide and roll over test in preeclampsia and normotensive pregnancy.
Method: This study was an analytic cross sectional research conducted in Dr. Wahidin Sudirohusodo Hospital, Barabaraya, Mamajang and Antang Health Center in Februar-June 2020. This study was financed by internal grant UNHAS in 2020 with contract number 1585/UN4.22/PT.01.03/2020. The subjects in this study were women aged 20-25 years with a single pregnancy, above 20 weeks gestational who were divided into 2 grups of 50 preeclampsia and 100 normotensive. ET - 1 and NO levels was checked using ELISA Method and ROT was measured by mercury spignomanometer.
Result: ET - 1 and NO levels serum were higher in preeclamptic group (42.27 +- 9.24 vs 37.13 +- 9,44; p = 0.002 and 176.43 +- 50.8 vs 152.75 +- 51.3; p = 0.012). ROT were higher in preeclamptic group (23.40 +- 8.77 vs 19.70 +- 8.69; p = 0.026).
Conclusion: Preeclampsia group had higher levels of ET - 1, NO and ROT values than normotention.
Keywords: Endothelin-1, Nitric Oxide, Roll Over Test, Preeclampsia
