Effect of Zinc Administered on Plasma Prostaglandin Level as Primary Dysmenorrhea Therapy Eva Kurnianti, Sriwijaya Qadar, Lenny Maria Lisal, Firdaus Kasim, Nusratuddin Abdullah, Nasrudin Abdullah
Division of Reproductive Endocrinology and infertility, Obstetrics and Gynecology Department, Hasanuddin University, Makassar, Indonesia
Abstract
Abstract
Objective: Primary dysmenorrhea is menstrual pain that is not related to pelvic organ abnormalities. Increased prostaglandin levels are found in women with primary dysmenorrhea and correlate with pain levels. Zinc reduces prostaglandin synthesis through its ability as an antiinflammatory and catalyst of antioxy and endogenous that can improve micro blood vessel circulation.
Method : This study is a quasi-clinical trial with randomization. Statistical data was analyzed with SPSS version 21.
Results: The mean PGF2alpha level in the group of women given standard therapy with zinc decreased significantly from 675.14 plus minus 1101.11 to 417.79 plus minus 804.04, p 0.04. The mean Visual Analogue Scale (VAS) also decreased from 6.91 plus minus 0.70 to 1.49 plus minus 0.59, p 0.000.
Conclusion: Administered of standard therapy accompanied by zinc that begins 2 days before menstruation can reduce levels of prostaglandins (PGF2alpha) and pain intensity in primary dysmenorrhea.
