CORRELATION OF GLYCATED HAEMOGLOBIN WITH NETRIN-1 AND HIGH SENSITIVE C-REACTIVE PROTEIN IN TYPE 2 DIABETES MELITUS PATIENTS Erika Rosaria Simbolon (a*) , Nurahmi (b,c) , Liong Boy Kurniawan (b,d)
a) Clinical Pathology Specialist Program, Medicine Faculty of Hassanuddin University. Jalan Perintis Kemerdekaan KM 10,Makassar, 90245. Indonesia
*erikarosariasimbolon[at]gmail.com
b) Clinical Pathology Department, Medicine Faculty of Hasanuddin University
c) Kota Makassar Hospital
d) Hasanuddin University Hospital, Makassar
Abstract
Objective : The purpose of this study was to determine the correlation between glycated haemoglobin (HbA1c) with netrin-1 and high sensitive C-Reactive Protein (hsCRP) in type 2 Diabetes Mellitus (DM) patients
Method : This cross sectional study used type 2 DM patients as a sample. Fifty two type 2 DM patients participated in this study. All patient was measured for HbA1c, netrin-1 and hsCRP. The glycated haemoglobin was measured using immunoturbidimetry method, netrin-1 was measured using the ELISA method and hsCRP by immunoturbidimetry method . Data were analyzed statistically with the Mann Whitney and Spearman test.
Results : Glycated haemoglobin did not not correlate with netrin-1 (p>0.05). Glycated haemoglobin was positively correlated with hsCRP with moderate correlation strength (p<0.01, r = 0.418). Netrin-1 did not correlate with hsCRP (p>0.05).
Conclution : Glycated haemoglobin did not correlate with netrin-1. Increased hsCRP is associated with elevated HbA1c in type 2 DM patients.
Keywords: Type 2 diabetes mellitus, glycated haemoglobin , netrin-1, hsCRP
