Role of Coronary Capillary Circulation in Coronary Artery Disease Idar Mappangara (a), Andrea Wahyu Yogasusanto(a*), L Tri (a)
(a). Department of Cardiology and Vascular Medicine, Hasanuddin University
*Jalan Perintis Kemerdekaan, KM 10. Makassar, South Sulawesi
idarmks[at]yahoo.com
Abstract
Abstract:
Objective: Coronary artery disease is a leading cause of death in woman. This paper aims to present the role of microcirculation in atherosclerotic coronary artery disease.
Method: A review of literature in Google scholar and Pubmed with keyword of microcirculation in coronary artery disease were used to search the data in September 2019.
Result: Increased myocardial oxygen demand are fulfilled in accordance with Ficks principle, MVO2 = CBF X (CaO2-CvO2). Increased myocardial oxygen demand (MVO2) could be met by increased coronary blood flow (CBF) or myocardial oxygen extraction (CaO2-CvO2). Myocardial oxygen extraction could be achieved through homogenization of capillary flow. In response to increased metabolic demand, the constricted capillary vessels need to be dilated and the non-functional ones need to be recruited to ensure homogenic circulation, expressed as a novel parameter capillary transit time heterogeneity (CTH). Microcirculatory dysfunction resulting in inability to homogenize capillary flow could manifest as angina.
Conclusion: Microcirculation plays an important role in coronary artery disease.
