THE EFFECT OF POKEA CLAM CONSUMPTION ON THE EXPRESSION OF ENDOTHELIAL NITRIC OXYDE SYNTHASE I Putu Sudayasa1, Suryani Asad1, Rosdiana Natsir1, Venny Hadju1, Mochammad Hatta1, Muh. Nasrum Massi1, Burhanuddin Bahar1, Sri Rahmadhani1, Yusmina Hala2, La Ode Alifariki3
1 Postgraduate Study Program in Medicine, Postgraduate Program at Hasanuddin University, Makassar, South Sulawesi, Indonesia
2 Postgraduate School of Negeri Makassar University, Makassar, South Sulawesi, Indonesia
3 Medical Study Program, Faculty of Medicine, University of Halu Oleo, Kendari, Indonesia
Abstract
Introduction: This study aimed to analyze the effect of consumption of pokea shellfish (Batissa violacea var. Celebencis von Marten 1897) on the expression of the enzyme endothelial nitric oxyde synthase (eNOS) gene in hypertensive and non-hypertensive patients in Sampara District, Konawe Regency.
Method: This study used an observational analytic method with a case-control study design through a molecular biology approach. The research location is in the Sampara subdistrict area. The total sample is 60 people consisting of 30 case samples and 30 control samples using a purposive sampling technique. Data were collected using a pokea shellfish consumption pattern questionnaire, a Semi-Quantitative Food Frequency Questionnaire (FFQ SQ) questionnaire, and laboratory examination data on eNOS gene expression. Data analysis with dependent t-test.
Result: Variable distribution of pokea clam meat consumption, the hypertension group respondents had a mean value and standard deviation of 35.14 (17.66), while the non-hypertensive respondents group was 41.10 (19.82). In the variable levels of the eNOS, the hypertension group had a mean and standard deviation of 11.76 (1.83) umol / L, while the non hypertensive group had of 6.53 (1.67) umol/L. The results of the statistical test analysis showed that there was an effect of pokea clam consumption on the expression of the eNOS gene (p=0.000) Conclusion: Pokea clam consumption affects the expression of the eNOS gene in Nonhypertensive and Hypertension Patients in Sampara District, Konawe Regency, Southeast Sulawesi.
