ROLE OF INTERLEUKIN 1B; IN AUTOIMMUNE DISEASE, A MINI REVIEW 1Rachmawati M, 2Tutik H, 3Moch H, 1Mansyur A
1Clinical Pathology Department, Hasanuddin University
2Clinical Medical Department. Hasanuddin University
3Microbiology Clinic Department, Hasanuddin Univesity
Abstract
Autoimmunity is generally defined as a phenomenon in which antibodies or T cells react with autoantigens. Autoimmunity induces autoimmune diseases. Epidemiologically, autoimmune diseases are common in women. Recent studies have revealed that such autoantibodies or autoreactive T cells exist even in healthy individuals. The immune system has various mechanisms to suppress the immune response to the self, and the disturbance of these mechanisms results in autoimmune diseases. Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance of interleukin-1 in linking innate immunity with a broad spectrum of diseases beyond inflammatory diseases. The cytosolic segment of each IL-1 receptor family member contains the Toll-IL-1-receptor domain. This domain is also present in each Toll-like receptor, the receptors that respond to microbial products and viruses. Since Toll-IL-1-receptor domains are functional for both receptor families, responses to the IL-1 family are fundamental to innate immunity. Of the 11 members of the IL-1 family, IL-1β has emerged as a therapeutic target for an expanding number of systemic and local inflammatory conditions called autoinflammatory diseases. For these, neutralization of IL-1B; results in a rapid and sustained reduction in disease severity. Treatment for autoimmune diseases often includes immunosuppressive drugs whereas neutralization of IL-1B; is mostly anti-inflammatory
Keywords: Autoimmune disease, Interleukin 1B
Topic: Womens careers in Biomedical Science and Medicine
