Variation of Functional Monomers of Preparation of Imprinting Polymer for Selective Analysis of Glibenclamide Lasmaryna Sirumapea, Mauizatul Hasanah, Romsiah, Ensiwi Munarsih, Hilma, David Darwis
Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi
Abstract
Molecular imprinting technology (MIT) is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. In this report, we reported the synthesis, characterization and the application of MIP for glibenclamide. Synthesis was conducted on bulk polymerization method. The component or polymers are : trimethylolpropane trimethacrylate (TRIM) as crosslinker, chloroform and methanol as the porogen solvent, benzoyl peroxide were used as initiator and various of functional monomers were : methacrylic acid (MA), ithaconic acid (ITA). Extraction of the analyte was conducted on the mixture of acetic acid : methanol (15 : 85). Physical characterization applied to all the polymes included functional group identification using Fourier Transform Infrared (FTIR) spectrophotometer, showed that the polymers met the qualification of imprinted polymer- new peaks found indicates that analyte (glibenclamide) has been successfully grafted to the polymers. Morphology elaboration using Scanning Elctron Microscope (SEM-EDX). Adsorption performace was represent by imprinting factor (IF) and α- (analogue selectivity). Imprinting factor for MA, MM and ACr based polymers were found : 1,55, 18,2 and 5,9 respectively. The α- points showed those three polymers are selective for niacinamide.
