THE EVALUATION OF AZITHROMYCIN CLINICAL OUTCOME OF INPATIENT COVID-19 IN AJIBARANG REGIONAL HOSPITAL Heny Ekowati, Andra Nurjaya Maulana, Nialiana Endah Endriastuti
Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University
Abstract
Corona Virus Disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Antibiotics can be used to treat COVID-19, such as azithromycin. Azithromycin is a macrolide antibiotic with a broad spectrum. This study aims to see whether there is an effect of using azithromycin in COVID-19 patients. This research is descriptive observational with a retrospective data collection method. This research data is medical record data from inpatient COVID-19 patients at Ajibarang Regional Hospital for the period March 2020-June 2021. Data analysis was carried out regarding the effect of azithromycin use on patients^ clinical symptoms statistically using the Wilcoxon Test and the Sign Test. A total of 76 patients met the inclusion criteria because they used azithromycin monotherapy. The results of statistical tests show that there is an influence of the use of azithromycin on the clinical symptoms of cough parameters (p=0.0001) and asphyxia (p=0.0001) in patients with mild severity. In the group of patients with moderate severity, the results showed that there was an influence of the use of azithromycin on the clinical symptoms of SpO2 parameters (p=0.019), cough (p=0.016), and asphyxia (p=0.016). In the group of patients with severe severity, the results showed that there was an influence of the use of azithromycin on clinical symptoms in the parameters of temperature (p=0.014), cough (p=0.031), SpO2 (p=0.004), and asphyxia (p=0.004). There is an influence of the use of azithromycin on the clinical symptoms of COVID-19 patients for the period March 2020-June 2021 at Ajibarang Regional Hospital.
