Physicochemical Analysis of BC/HAP Composites with the Addition of Garcinia mangostana Extract as Antibacterial Agentubmit This Sample Abstract Galih Widyastama (a), Yessie Widya Sari (a*), Mersi Kurniati (a), Wulan Tri Wahyuni (b)
(a) Department of Physics, Bogor Agricultural Institute, Dramaga, Bogor 16680, Indonesia
*Corresponding author: yessie.sari[at]apps.ipb.ac.id
(b) Department of Chemistry, Bogor Agricultural Institute, Dramaga, Bogor 16680, Indonesia
Abstract
Osteomyelitis is an infection of bone tissue that involves inflammation and bone loss and the spread of bacterial infection to the surrounding soft tissue. Bacterial cellulose (BC) has been used in biotechnology for hard tissue engineering, and soft tissue engineering because of its characteristics, namely biocompatibility, high purity, high crystallinity and high mechanical properties. Hydroxyapatite (HA) is the main constitution of bone because bone contains 65-70% HA in addition to 5-8% water and 20-25% organic matter. Mangosteen fruit peels (Garcinia mangostana Linn.) showed antibacterial effect against gram-positive and gram-negative bacteria. This study aims to make a BC-HA composite with antibacterial properties from mangosteen peel extract by varying the concentration of HA and mangosteen peel extract (GM), and to characterize its mechanical and antibacterial properties. Composites were prepared by immersion method in GM extract. The mechanical properties of the composite were analyzed by Universal Testing Machine (UTM). The antibacterial properties of the composite were tested by measuring the zone of inhibition of bacteria against Staphylococcus aureus.
Keywords: Bacterial cellulose, bone implants, hydroxyapatite, mangosteen peels, osteomyelitis
