Prenylated Flavonoids from the twig bark of Artocarpus camansi (Kluwih) and Their Potential as Anticancer
Imam A. Rosyadi (a), Dikhi Firmansyah (a*), Lia D. Juliawaty (a)

a) Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha 10 Bandung, Indonesia
*dikhfi[at]itb.ac.id

Abstract

Artocarpus camansi known as kluwih is one of the species belonging to the Artocarpus genus. The main secondary metabolites of this genus are prenylated flavonoids, which have potential as anticancer agent. In this research, the acetone extract of the twig bark of A. camansi was separated and purified using several chromatography techniques to give three prenylflavones, namely cycloartobiloxanthone (1), morusin (2), and artonin E 2^ methylether (3). The structures of these compounds were determined by NMR spectroscopy. Cycloartobiloxanthone is the major secondary metabolite, 75 mg of the compound was obtained from 500 g of powdered twig bark samples. Among all, morusin had the best cytotoxic activity against P388 leukemia cells, IC50 value 3.1 ug/mL.

Keywords: Artocarpus camansi, kluwih, prenylflavones, P388

Topic: CHEMISTRY AND MATERIAL SCIENCES