A Brief Review On Aging And Its Combination With Bibliometric Analysis On Cellular Senescence Elimination As Part Of Anti Aging Strategies
Indah Hartati1a) Vita Paramita2b) Farikha Maharani1c) Lusiana3d) Laeli Kurniasari1e)

1Department of Chemical Engineering, Faculty of Enginering, Wahid Hasyim University, Indonesia
2 Department of Industrial Chemical Engineering Technology Vocational School, Diponegoro University, , Indonesia
3Department of Physical Education, Health and Recreation, Faculty of Teaching and Education, Wahid Hasyim University , Indonesia

Abstract

It is estimated that in 2050, the growth of the aging population in the world is growing faster than the one of the younger age people. Consequently, the high growth rate of elderly population has become a major challenge due to its strong correlation on social and economics condition. Therefore in this work, the definition of aging, hallmarks of aging, aging theory, as well as anti aging strategies are reviewed. The review was combined with bibliometric analysis on publication having ^anti aging strategies^ as well as ^senolytics and cellular senescence^ keywords. Aging, a process of cellular deterioration, is associated with oxidative stress and the accumulation of toxic peroxidation products. The developments of the aging hallmarks proposed are summarized. Regarding the aging theory exist there are Chinese medicine based theory as well as modern theory. Among the aging theory proposed, free radical theory plays a significant role in the aging process. Bibliometric analysis of anti aging strategies informs that cellular senescence is emphasized while dasatinib, fisetin, quercetin, and navitoclax as the four senolytics agents appear on the network visualization of keyword occurrence in publication with ^senolytics and cellular senescence^ keywords. Among the four senolytics agents, two natural based compounds of senolytics agent i.e quercetin and fisetin. Due to the varied sources, both of fisetin and quarcetin would play a great role in the development of senolytics agent obtained from natural resources. The development of isolation methods will also emphasize further research, especially in the finding green chemicals and green separation and isolation routes.

Keywords: aging, cellular senescence, anti aging, review, bibliometric

Topic: Chemical Engineering