Structure- antioxidant Activity Relationship of Flavonoids from Three Species of Indonesian Artocarpus
Fera Kurniadewi*1), Iqbal Musthapa 2), Lita Amalia Ramadhan 1), Muktiningsih 1), Irma Ratna Kartika 1), Hanhan Dianhar 1),Kifka Aredesya 1)

1) Chemistry Study Program, Universitas Negeri Jakarta, Jalan Rawamangun Muka, Jakarta, 13220
2) Chemistry Study Program, Universitas Pendidikan Indonesia, Jalan Gegerkalong, Bandung

Abstract

The antioxidant activities of six flavonoids having different basic chemical structures from three artocarpus species (A. nangkadak, A. champeden, and A. altilis) were studied to establish their structure-activity relationships using the DPPH method. Special attention was paid to the flavonoids Kudraflavone C (flavone), artocarpin (flavone), and artocapanon (flavane), which possess different basic structures but the same hydroxylation pattern (2^ and 4^ -OH) in the B-ring. It was found that these three flavonoids exhibited comparable antioxidant activities against DPPH leading to the conclusion that the presence of 7-OH group, 2^ and 4^-OH groups in the B-ring and 2,3-double bond is a determinant of a high antioxidant capacity. Moreover, the presence of prenyl groups and structural modification involving these groups to flavonoids such as cyclization of the 3-prenyl to make a pyranohydrobenzoxanthone type (cycloartocarpine, cyclomorusin, cyclocommunol) can decrease antioxidant activities.

Keywords: Artocarpus, Antioxidant, Structure- antioxidant Activity Relationship

Topic: Chemistry