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OVERVIEW OF HEPATOCELLULAR CARCINOMA PATIENTS IN CENTRAL GENERAL HOSPITAL DR. HASAN SADIKIN BANDUNG 2018-2020 a) Pathology Anatomy Departement, Faculty of Medicine, Jenderal Achmad Yani University, Cimahi, Indonesia Abstract Hepatocellular carcinoma is malignancy originates from hepatocyte cells. This cancer was the 3rd leading cause death worldwide due to cancer in 2020. Many patients with hepatocellular carcinoma are diagnosed at late stage where a poor prognosis. The purpose of this study was to describe hepatocellular carcinoma patients at Central General Hospital Dr. Hasan Sadikin Bandung. This study uses descriptive method and sample was taken from medical record of patients diagnosed with hepatocellular carcinoma from Medical Record Center of Hasan Sadikin Hospital 2018-2020 period with total sampling technique. The results showed that 156 patients were diagnosed with hepatocellular carcinoma with 69 patient meets our inclusion criteria. The most risk factor was liver cirrhosis with 27 patients (39,1%). 56-65 years age group was the most diagnosed with 21 patients (30.4%). Men were found more often than women with ratio 3:1. The most common clinical manifestations were abdominal pain and lethargy in 20 patients (29.0%). Stage D according to BCLC was the most common stage found with 26 patients (37.7%). The conclusions are liver cirrhosis was the most common risk factor of hepatocellular carcinoma. Most suffered in old age, male sex, and most common clinical manifestations are abdominal pain and lethargy with the most common stage according to BCLC was stage D. In liver cirrhosis, activated liver stellate cell causing continuous hepatocyte cell proliferation which the most common risk factor in this study. Hepatocellular carcinoma mostly occurs in men due to androgen receptor binding to EZH2 which inhibits p-53 gene. Keywords: BCLC, hepatocellular carcinoma, hepatocyte Topic: Biomedical Science |
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