POTENCY OF RED GUAVA FRUITGHURT ON TOTAL CHOLESTEROL LEVELS
Ania Kurniawati Purwa Dewi(1), Haura Khoerunnisa Badriarti(2), Yanti Nurrokhmawati(3)

1)Department of Microbiology, Faculty of Medicine, Jenderal Achmad Yani University, 2)Department of General Medicine, Faculty of Medicine, General Achmad Yani University, 3)Department of Ear Nose Throat Health Sciences - Head and Neck Surgery, Faculty of Medicine, Jenderal Achmad Yani University / Dustira Hospital.

Abstract

High total blood cholesterol levels are a risk factor for atherosclerosis and coronary heart disease. Probiotics are one of the potential foods that if consumed regularly can lower blood cholesterol levels. Fruitghurt is a probiotic whose raw materials come from fruits. The purpose of this study was to determine the effect of giving red guava fruitghurt on total blood cholesterol levels in male Wistar strain rats induced by a high-fat diet. The research design used is an experimental laboratory. The research subjects used white rats (Rattus norvegicus) wistar strain which were divided into 5 treatment groups. Data analysis was performed by T-dependent test, one way ANOVA and post hoc tukey. Based on the results of the T-dependent test, it can be concluded that there is a significant effect of giving red guava fruitghurt to decrease total cholesterol levels. Lactic acid bacteria contained in fruitghurt can increase the secretion of bile salt hydolase enzymes which can increase bile acid excretion so that total blood cholesterol levels can be reduced. In addition, lactic acid bacteria can also produce dehydrogenated cholesterol cofactors which function to activate the cholesterol reductase enzyme, causing sterols to be unable to be absorbed by the intestine, so total cholesterol will decrease. This proves that red guava fruitghurt has an antihypercholesterolemic effect in rats induced by a high-fat diet.

Keywords: Probiotics, Fruitghurt, total cholesterol

Topic: Biomedical Science