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The Efectiveness Of Green Tea Polyphenols In Minimalizing Mercury-Induced Rat Glomerular Basal Membrane Damage a) Departemen Histologi, Fakultas Kedokteran Universitas Jenderal Achmad Yani, Cimahi, Jawa Barat, Indonesia Abstract Green tea polyphenols are the main element in green tea with high antioxidant activities that considered as a first line of defense against free radicals in the body which can be caused by mercury intoxication. Mercury is a dangerous heavy metal against human body. Mercury can absorbed and damaged many vital organs, including kidney. Mercury-induced membranous nephropathy is a disease within kidney which manifests as a thickening of glomerular basal membrane. The purpose of this study is to determine the efectiveness of green tea polyphenols for minimalizing glomerular basal membrane damage causes by mercury in rat. Study used experimental post-test only control group design against 24 paraffin blocks of rat kidney which divided into five groups. The data was taken in the form of glomerular basal membrane area. Data analysis was done with a nonparametric test Kruskal-Wallis because the data is not distributed normally and then analysis is continued with a post hoc Mann-Whitney test. The average area of glomerular basal membrane in each groups were KN 204,727, KP 410,741, P50 376,991, P100 296,572 and P200 207,552. Kruskal Wallis test found a significant difference among the five groups). Meanwhile post hoc test found a significant difference between P100 and positive control group. Antioxidant activites within green tea polyphenols has statistically proven to minimalize basal membrane damage in rat kidney and 100 mg kg of green tea polyphenols were the most effective dose. Keywords: Green tea polyphenols, glomerular basal membrane damage, mercury Topic: Biomedical Science |
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